Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

As previously disclosed, on November 8, 2019, Federico A. Monzon, M.D., Chief Medical Officer of Castle Biosciences, Inc. (the "Company"), notified the Company of his intention to resign effective on or about April 1, 2020, which was subsequently delayed. On May 21, 2020, Dr. Monzon notified the Company that his resignation will be effective as of May 31, 2020.

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