Item 1.01 Entry into a Material Definitive Agreement.

On June 30, 2020, Mirati Therapeutics, Inc. ("we," "Mirati" or the "Company") entered into an amended and restated lease agreement (the "Amended and Restated Lease") with ARE-SD Region No. 38, LLC (the "Landlord") for the lease of approximately 118,225 square feet of office and laboratory space located at 3545 Cray Court, San Diego, California 92121 (the "Premises"), for the Company's future principal executive offices, and laboratory space for research and development and related uses. The Premises shall be delivered in two phases to the Company with the initial Premises containing 54,505 square feet and the subsequent Premises containing 63,720 square feet.

The commencement date of the Amended and Restated Lease is expected to be March 22, 2021, and the Amended and Restated Lease will have a lease term of 12 years (the "Lease Term"), unless terminated earlier. The Lease Term has an initial abatement period, and the initial base rent payable will be approximately $0.6 million per month for the Premises following the abatement period, which amount will increase by 3% per year over the Lease Term. The Amended and Restated Lease amends, restates and supersedes in its entirety the lease agreement dated as of August 22, 2019, by and between the Company and the Landlord.

The foregoing description of the Amended and Restated Lease does not purport to be complete and is qualified in its entirety by reference to the full text of the Amended and Restated Lease, of which a full copy will be filed with the Securities and Exchange Commission as an exhibit to the Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2020.

Item 8.01 Other Events.

On July 2, 2020, the Company entered into a sales agreement (the "Sales Agreement") with Cowen and Company, LLC ("Cowen"), pursuant to which the Company may, from time to time, sell shares of the Company's common stock, par value $0.001 per share (the "Shares"), having an aggregate offering price of up to $200,000,000 through Cowen, as the Company's agent and/or principal.

Subject to the terms and conditions of the Sales Agreement, Cowen will use its commercially reasonable efforts to sell the Shares from time to time, based upon the Company's instructions. The Company has provided Cowen with customary indemnification rights, and Cowen will be entitled to a commission of up to 3.0% of the gross sales price of the Shares sold through it pursuant to the Sales Agreement.

The Shares will be offered and sold by the Company pursuant to its registration statement on Form S-3ASR (Registration Statement No. 333-227209) which became automatically effective upon filing with the Securities and Exchange Commission (the "SEC") on September 6, 2018. The Shares may be offered only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. Sales of the Shares, if any, under the Sales Agreement may be made in transactions that are deemed to be "at the market offerings" as defined in Rule 415 under the Securities Act of 1933, as amended, including sales made by means of ordinary brokers' transactions, including on The Nasdaq Global Select Market, at market prices or as otherwise agreed with Cowen. The Company has no obligation to sell any of the Shares, and may at any time suspend offers under the Sales Agreement or terminate the Sales Agreement.

The foregoing description of the Sales Agreement does not purport to be complete and is qualified in its entirety by reference to the full Sales Agreement, a copy of which is attached hereto as Exhibit 1.1 and is incorporated by reference herein.

This Current Report on Form 8-K does not constitute an offer to sell the Shares or a solicitation of an offer to buy the Shares, nor shall there be any sale of the Shares in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

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Item 9.01 Financial Statements and Exhibits.




(d) Exhibits

Exhibit No.                                    Description

    1.1                Sales Agreement, dated July 2, 2020, between Mirati
                     Therapeutics, Inc. and Cowen and Company, LLC.

    5.1                Opinion of Cooley LLP.

    23.1               Consent of Cooley LLP (included in Exhibit 5.1).

    104              Cover Page Interactive Data File (embedded within the Inline
                     XBRL document).

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