Toshiba Corporation (TOKYO: 6502), Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Tohoku University Hospital have demonstrated that quantum cryptographic communications technology can provide genomic medicine with a safe, completely secure data management environment.

This was achieved by (1) developing a system which applies quantum cryptographic communications technology to clinical sequencing, and (2) using that system to safely transmit cancer genome analysis data (exome sequence (Note 1) data), via online expert panel attended by physicians and other experts to analyze the sequenced data. This is the world's first development and demonstration of a system using quantum cryptographic communication technology in the field of genomic medicine.

Clinical sequencing is a new examination in genomic medicine that uses a next-generation sequencer to read a patient's gene sequence at ultra-high speed. The results of the genomic data analysis are then provided to physicians and other experts to assist in patient diagnosis and treatment selection. This system builds on and extends capabilities that Toshiba and ToMMo announced in January of this year, and the achievements of this demonstration are a major step toward a practical system that will provide safe and secure genomic medicine.

This research was carried out as part of the Strategic Innovation Creation Program (SIP) of the Council for Science and Technology and Innovation of the Cabinet Office, 'Society 5. 0 Realization Technology Utilizing Light and Quantum' (Quantum Science and Technology Research and Development Organization). Toshiba, ToMMo and Tohoku University Hospital will present the details of the demonstration and the technology at the International Conference QCrypt 2020 (10th International Conference on Quantum Cryptography) on August 10-14.

Details

In January this year, Toshiba and ToMMo announced on a series of experiments of quantum cryptography transmission that took place in July and August 2019 that succeeded in transmitting whole-genome sequence data for the first time anywhere in the world (Note 3). Since then, and joined by Tohoku University Hospital, they have advanced the research by focusing on two areas related to clinical sequencing of cancer patients: the type of data that must be kept confidential and methods to utilize quantum cryptographic technology in data decryption.

Clinical sequencing covers genome analysis data which is highly confidential personal information closely related to one's health and physical condition that must be kept secure. For the same reason, support is also needed for the data generated by online expert panel attended by physicians and experts who share patient's genetic data and diagnostic results via remote access.

After considering this, Toshiba, ToMMo and Tohoku University Hospital successfully demonstrated encryption in two areas using quantum cryptographic communication technology:

Real-time transmission of genome analysis data (exome sequencing data)

Data transmission for an online expert panel, including analyzing results over conference audio and visual feeds.

Implementation of A: Transmission of genome analysis data uses a one-time pad (Note cryptography that Toshiba and ToMMo announced in January 2020

Genome data is encrypted as it is sequenced, with a cryptographic key distributed from the quantum key distribution system, and transmitted using the one-time pad. The transmission system is designed for ease of use. Menus on the operator's screen allow simple selection of the number of the specimen for analysis, and of the transmission method.

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