On November 1, 2022, Isaac Cheng, MD, a member of the board of directors of Amylyx Pharmaceuticals, Inc., submitted his resignation from the board of directors, effective as of close of business on November 1, 2022. Dr. Cheng's decision to resign was not the result of any disagreement with the company on any matter relating to its operations, policies practices or any issues relating to the company's accounting principles, practices, financial statements or disclosures.