DEINOVE disclosed the details of the paper presented at the ASM Microbe 2019 congress by Major Steven Zumbrun, PhD in Microbiology at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). Major Steven Zumbrun presented the results of the in vitro evaluation of DNV3681 against Bacillus anthracis and Francisella tularensis. He concluded that DNV3681 has "exceptional activity" against these two bio-threat agents. The USAMRIID team determined the efficacy of DNV3681 by measuring its MIC90, the minimum concentration necessary to inhibit the growth of 90% of a panel of test bacterial isolates. This value is 0.015 g/ml against Bacillus anthracis, making it a more effective molecule than Ciprofloxacin. Bacillus anthracis and Francisella tularensis are classified as two of the most dangerous possible biological weapons. The standard of care against Bacillus anthracis and Francisella tularensis is currently Ciprofloxacin, a synthetic large spectrum antibiotic from the fluoroquinolones’ family. Several pathogenic bacterial species have already developed a resistance against this family of antibiotics and the long treatment needed for Post-exposure Prophylaxis of Anthrax very often triggers a major intestinal microbiota imbalance leading to likely Clostridioides difficile infections. Therefore, there is an urgency to make efficient and validated alternatives available. The fact that the DNV3681 is precisely very active against both Bacillus anthracis and Clostridioides difficile makes it an ideal candidate to fulfill that need.