- The last patient was treated with AsiDNA™ in combination with carboplatin and paclitaxel in this Phase 1b study in patients with advanced solid tumors.
- The good safety profile of AsiDNA™ is confirmed to date, with no serious adverse events related to AsiDNA™ and no dose-limiting toxicities observed.
- Of the first seven patients, four had a partial response or longer periods of control of their disease than with previous treatment lines; three patients are still being treated.
- These preliminary data represent a particularly encouraging signal of efficacy and support further clinical development of AsiDNA™ in combination with these reference chemotherapies.
DRIIV-1b was designed to evaluate the safety and efficacy of AsiDNA™ in combination with carboplatin (n=3) and then carboplatin plus paclitaxel (n=6) in eligible patients with metastatic solid tumors, progressing at inclusion. The last planned patient has received treatment and will be followed until disease progression.
At this stage and on the first seven patients evaluated for safety, the favorable safety profile of AsiDNA™ in combination with carboplatine +/- paclitaxel is confirmed, as no serious adverse events related to AsiDNA™ and no dose-limiting toxicities have been observed in these patients.
In terms of efficacy, four of the seven patients experienced a partial response and/or longer durations of disease control than with previous treatment lines. Three patients are still being treated. These preliminary data represent a particularly encouraging signal of efficacy that supports further clinical development of AsiDNA™ in combination with these reference chemotherapies.
About DRIIV-1b
DRIIV-1b is designed to evaluate the safety and efficacy of AsiDNA™ in combination with carboplatin (n=3) and carboplatin plus paclitaxel (n=6) in patients with advanced metastatic solid tumors progressing at inclusion. The efficacy of these combinations is evaluated every 6 to 8 weeks by medical imaging (Criteria for Evaluation of Response in Solid Tumors - RECIST). Out of the first seven evaluable patients, four patients, including three non-small cell lung cancer (NSCLC) patients, had a partial response and/or long control durations (no progression). For these four patients, the durations of control with either combination was consistently longer than those obtained with previous treatment lines, including other platinum-based chemotherapies or a first-line reference immunotherapy.
About
platON™ is Onxeo’s proprietary chemistry platform of oligonucleotides acting as decoy agonists, which generates new innovative compounds and broaden the Company’s product pipeline.
AsiDNA™, the first compound from platON™, is a first-in-class, highly differentiated DNA Damage Response (DDR) inhibitor based on a decoy and agonist mechanism acting upstream of multiple DDR pathways. Translational research has highlighted the distinctive properties of AsiDNA™, notably its ability to abrogate tumor resistance to PARP inhibitors regardless of the genetic mutation status. AsiDNA™ has also shown a strong synergy with other tumor DNA-damaging agents such as chemotherapy and PARP inhibitors. The DRIIV-1 (DNA Repair Inhibitor-administered IntraVenously) phase I study has evaluated AsiDNA™ by systemic administration (IV) in advanced solid tumors and confirmed the active doses as well as a favorable human safety profile. The ongoing DRIIV-1b extension study is assessing the safety and efficacy of a 600 mg dose of AsiDNA™ in combination with carboplatin and then with carboplatin and paclitaxel, in patients with solid tumors who are eligible for such treatments.
OX401 is a new drug candidate from platON™, optimized to be a next-generation PARP inhibitor acting on both the DNA Damage Response and the activation of immune response, without inducing resistance. OX401 is undergoing preclinical proof-of-concept studies, alone and in combination with immunotherapies.
For further information, please visitwww.onxeo.com.
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Contacts
Investor Relations investors@onxeo.com +33 1 45 58 76 00 | Media Relations Nicolas Merigeau NewCap onxeo@newcap.eu +33 1 44 71 94 98 | Investor Relations / Strategic Communication Dušan Orešanský / NewCap onxeo@newcap.eu +33 1 44 71 94 92 Investor Relations US britchie@lifesciadvisors.com +1 212 915 2578 |
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