OPKO Health : Immediate Report

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

(Print or Type Responses)

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STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Phillip Frost, M.D., ET AL

(Last)	(First)
OPKO Health, Inc.
4400 Biscayne Blvd.
	(Street)
Miami, FL 33137
(City)	(State)

	2. Issuer Name and Ticker or Trading Symbol
	OPKO Health, Inc. [ OPK ]
(Middle)	3. Date of Earliest Transaction (Month/Day/Year)
	05/17/2024
	4. If Amendment, Date Original Filed (Month/Day/Year)
(Zip)

5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director	__ X __ 10% Owner
__ X __ Officer (give title below)	_____ Other (specify below)

CEO & Chairman

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person

_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction		4. Securities Acquired (A) or
(Instr. 3)	Date (Month	Execution	Code		Disposed of (D)
	/Day/Year)	Date, if any	(Instr. 8)		(Instr. 3, 4 and 5)
		(Month/Day
		/Year)
						(A) or
			Code	V	Amount	(D)	Price
Common Stock	05/17/2024		P		163,997	A	$ 1.2878
		(1)

Common Stock

Common Stock

5. Amount of Securities Beneficially Owned	6.	7. Nature
Following Reported Transaction(s)	Ownership	of Indirect
(Instr. 3 and 4)	Form:	Beneficial
	Direct (D)	Ownership
	or Indirect	(Instr. 4)
	(I)
	(Instr. 4)
		See
211,132,222	I	Footnote
		(2)
3,068,951	D
		See
30,127,177	I	Footnote
		(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned

( e.g. , puts, calls, warrants, options, convertible securities)

1. Title of Derivative

2. Conversion

3. Transaction

3A. Deemed

4. Transaction

5. Number of

6. Date Exercisable and Expiration

7. Title and Amount of

Security

or Exercise

Date (Month

Execution

Code

Derivative Securities

Date

Underlying Securities

(Instr. 3)

Price of

/Day/Year)

Date, if any

(Instr. 8)

Acquired (A) or

(Month/Day/Year)

(Instr. 3 and 4)

Derivative

(Month/Day

Disposed of (D)

Security

/Year)

(Instr. 3, 4, and 5)

Date Exercisable Expiration Date

Title

Amount or

Number of Shares

Code

V

(A)

(D)

Reporting Owners

Reporting Owner Name / Address

Relationships

Director

10% Owner Officer

Other

Phillip Frost, M.D., ET AL

OPKO Health, Inc.

X

X

CEO & Chairman

4400 Biscayne Blvd.

Miami, FL

33137

Frost Gamma Investments Trust

OPKO Health, Inc.

X

4400 Biscayne Blvd.

Miami, FL

33137

8. Price of	9. Number	10.	11. Nature
Derivative	of	Ownership	of Indirect
Security	Derivative	Form of	Beneficial
(Instr. 5)	Securities	Derivative	Ownership
	Beneficially	Security:	(Instr. 4)
	Owned	Direct (D)
	Following	or Indirect
	Reported	(I)
	Transaction	(Instr. 4)
	(s)
	(Instr. 4)

Explanation of Responses:

1. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.285 to $1.29, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the "Company"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4.
2. The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
3. These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Signatures

Phillip Frost, M.D., Individually and as Trustee 05/17/2024

** Signature of Reporting Person

Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

• If the form is filed by more than one reporting person, see Instruction 4(b)(v).
• Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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