Portola Pharmaceuticals, Inc. announced the appointment of Glenn Brame as senior vice president of technical operations, effective immediately. Mr. Brame will report to Mardi Dier, interim co-president and chief financial officer, and will be responsible for leading the company’s technical operations including process development, manufacturing, supply chain, quality assurance, and end-to-end process and platform optimization for Portola’s entire portfolio. He will also serve as a member of Portola’s Executive Committee, contributing directly to global expansion efforts and related CMC activities. Prior to joining Portola, Mr. Brame was vice president of supplier and contract manufacturing excellence for Genentech, where he was responsible for the transformation of quality, manufacturing, technical services and supply chain operations for both biologics and small molecule products.