Item 7.01 Regulation FD Disclosure.

On May 29, 2020, Adaptimmune Therapeutics plc (the "Company" or "Adaptimmune") issued a press release announcing a presentation of updated data from its ADP-A2M4 Phase 1 trial in an oral presentation by Dr. David Hong of the MD Anderson Cancer Center at the American Society for Clinical Oncology (ASCO) Annual Meeting held in virtual format. The data demonstrate durability and responses in synovial sarcoma, supporting SPEARHEAD-1 as a potential registrational trial. The ASCO presentation also describes a new response in a patient with lung cancer, and a response in a patient with head and neck cancer (reported in January 2020).

The Company also announced new responses in its SURPASS trial, confirming the potential for SPEAR T-cell therapies targeting MAGE-A4 to treat a broad range of cancers in addition to sarcoma. These data further support the rationale for two new Phase 2 trials - SPEARHEAD-2 in head and neck cancer, which will begin later this year, and a second trial in esophagogastric junction cancer planned for the first half of 2021.

The press release is furnished as Exhibit 99.1 and is incorporated by reference herein.

The information in this Item 7.01, including Exhibit 99.1, shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act") or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

Item 9.01 Financial Statements and Exhibits.






(d) Exhibits.



Exhibit No.                             Description of Exhibit
   99.1         Press release dated May 29, 2020
    104       Cover Page Interactive Data File (embedded within the Inline XBRL document)

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