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MarketScreener Homepage  >  Equities  >  OTC Bulletin Board - Other OTC  >  Angiogenex Inc    AGGX

ANGIOGENEX INC

(AGGX)
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ANGIOGENEX : Management's Discussion and Analysis of Financial Condition and Results of Operations (form 10-Q)

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08/14/2019 | 05:13pm EDT

This management's discussion and analysis ("MD&A") of the financial condition and results of operations of the Company should be read in conjunction with our unaudited condensed consolidated financial statements and accompanying notes for the three and six months ended June 30, 2019 and 2018, which have been prepared in accordance with United States generally accepted accounting principles ("U.S. GAAP"). All dollar amounts are in U.S. dollars ("US$" or "$") unless stated otherwise.

Our MD&A is intended to enable readers to gain an understanding of our current operating results and financial position. To do so, we provide information and analysis comparing the results of operations and financial position for the current period to those of the preceding comparable period. We also provide analysis and commentary that we believe is required to assess our future prospects. Accordingly, certain sections of this report contain forward-looking statements that are based on current plans and expectations. These forward-looking statements are affected by risks and uncertainties that are discussed in Item 1A of this Form 10-Q and Item 1A of our Annual Report on Form 10-K filed on March 28, 2019 (the "2018 Annual Report on Form 10-K"), and above in the section titled "Special Note Regarding Forward-Looking Statements"; such risks and uncertainties could have a material impact on future prospects. Readers are cautioned that actual results could vary from those forecasted in this MD&A.



1. Executive Summary


Background and History of the Company. AngioGenex, Inc., and our wholly owned subsidiary AngioGenex Therapeutics, Inc. ("AngioGenex," "we," "us," "our" or the "Company") is a public bio-pharmaceutical company dedicated to the development and commercialization of a novel, inexpensive treatment for vascular diseases including many forms of cancer and macular degeneration. The Company was incorporated in the state of Nevada on April 2, 1999. AngioGenex Therapeutics, Inc. was incorporated in the state of Nevada in May of 2004. AngioGenex Therapeutics merged with AngioGenex, Inc., a New York Corporation that was incorporated in March of 1999. The merger of these two entities was completed in 2005, and was treated as a reverse merger for accounting purposes.

The Science - Discovering the Target. Since the discovery of "Id" genes more than 20 years ago, Dr. Robert Benezra, the Company's Chief Scientific and Executive Officer ("CEO" and "CSO") and a Member at Memorial Sloan Kettering Cancer Center ("MSKCC"), has been pursuing the role of Id genes, and the proteins they express, in stimulating intrinsic tumor cell growth and blood vessel development to support such growth that occurs both in early fetal development and in the pathology of numerous important diseases. Subsequent experiments by Dr. Benezra with an "Id knock-out" mouse suggested that interfering with Id protein activity might prevent the establishment and spread of tumors that normally "dupe" the body into activating the Id mechanism for cancer cell proliferation and creating the new blood vessels cancer cells need to grow and spread. The role of the Id proteins as targets for neovessels and tumor cell proliferation, as well as metastasis, was further discussed in numerous scientific articles. The articles also discuss the Id mechanism and potential for disease prevention.

The Company's bio-pharmaceutical technology and its development plans are based on the hypothesis that Id protein-supported cell proliferation and neo-vascularization is central to the pathology of many forms of cancer and macular degeneration (a disease characterized by unregulated blood vessel growth in the eye), and that the inhibition of Id has a powerful positive effect on preventing the progression of many forms of cancer and macular degeneration.

The Company - Business Strategy. AngioGenex was created to capture the full potential of the Id platform. We currently own what we believe are unencumbered exclusive worldwide rights under issued and pending patents to a novel class of drugs that target the Id proteins. Central to this strategy is our symbiotic relationship with MSKCC, which includes a coordinated research and development ("R&D") program and clinical trial plan. MSKCC holds common stock in the Company that was granted in return for the efforts it contributed to Dr. Benezra's studies in discovering the role of the Id proteins and their potential as targets for disease intervention.

Product Development - Designing and Testing Novel Drugs. With the Company confident that the cell biology suggesting the importance of the target was established (as suggested in the following publications: "Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2 neu-dependent breast tumors" (de Candia et al, Proceedings of The National Academy of Sciences 2003), along with now 100s of




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publications pointing to the importance of these proteins in cancer initiation and progression), the next step was to try to hit that target with a drug that would inhibit Id, and prevent the process of tumor cell proliferation as well as new blood vessel formation, thereby impeding the spread of cancer cells. Attempting to do so required the creation of a company to complete the medicinal chemistry and preclinical development. Commercializing the concept required raising seed capital, organizing a team with the expertise to identify the target's molecular structure, conducting high through-put screening and rational drug design modeling, securing the intellectual property to protect findings and conducting the pre-clinical experiments with the most active "hits." The Company was created for that purpose and focused on developing this platform technology into the first Id-inhibitor drug. AngioGenex has accomplished key benchmarks since its inception by incubating the technology and concretizing the concept in the form of active proprietary chemical compounds, which are small molecules such as our two lead drug candidates that, based on unpublished data, the Company believes to have shown specific activity in various animal models of various cancers and macular degeneration.

Our two lead drug candidates are AGX51 and its derivative AGXA, with AGXA being the first drug candidate we are testing towards an Investigational New Drug Application ("IND"). The Company also has a number of other proprietary small molecules. Focusing on the exact three-dimensional atomic structure of the Id protein, our chemists designed drugs that we believe bind to the Id proteins and inhibit their activity, based on unpublished experimental data regarding the drugs' activity in in vitro tests, and from cell line and animal models of breast and other cancers and macular degeneration. The goal of these experiments was to see if, in pre-clinical models, AGXA and AGX51's other derivatives can reproduce the impact of Id gene deletion in preventing the Id proteins from performing their role in support of the establishment and spread of cancer. The Company's working hypothesis is that the Company's drugs interfere with Id activity both in the tumor cells themselves and the vessels that support their growth, and that this dual activity might support the Company's attempts to establish the superior performance of AGXA over other drugs which only inhibit blood vessel growth.

Competition. We believe that there is no other company developing an Id-based therapeutic, diagnostic or prognostic product. However, there are a large number of competitors developing cancer therapeutics based on an anti-angiogenic approach. There are also a significant number of companies developing therapeutics and diagnostics based on other technologies.

The leading drugs in the field of anti-angiogenic drug therapy are Genentech's Avastin for cancer (approximately $6.8 billion in sales in 2018) and Regeneron's Eylea for macular degeneration (whose sales lifted the company's market cap to over $50 billion in 2017). Both target a different molecule (Vascular Endothelial Growth Factor) that is active in normal adult biology with anti-bodies or "biologics".

Corporate Strategy - Pre-Clinical and Clinical Development. The Company's drugs (including our two lead drug candidates AGX51 and its derivative AGXA) are at the pre-clinical stage of development. Our Company would like to ultimately develop different Id-inhibitor drugs to treat cancer and macular degeneration.

For AGX51 or its derivative, the estimated timeframe and cost for completion of pre-clinical work is approximately 15 to 18 months and approximately $1.5 million to $2 million so that we can file an IND and the estimated cost to complete Phase I/IIA clinical trials is approximately $12 million. For a second compound and indication, the estimated timeframe and cost for completion of pre-clinical work is approximately 12 to 15 months and approximately $1.7 million so that we can file an IND and the estimated cost to complete Phase I/IIA clinical trials is approximately $8 million to $12 million. We estimate that we are only able to fund our current operations through August 2019 and will need to raise at least $1.7 million in capital to fund our pre-clinical development plan and related operational expenses.

Our first indication for the use of AGX51 or its derivatives will be in the most aggressive cancers that appear to depend on Id protein expression. IND enabling work is progressing against several of these tumor types and final selection will be dictated by efficacy and safety in animal models which bear primary human tumors taken directly from the operating room. With the initiation of these trials, designed to establish safety and proof of principle in humans, the Id story will have come full circle, from a basic biological finding in an academic lab to the discovery of an active chemical inhibitor to be tested on real patients in a clinic at the very institute where it all began. If we raise sufficient resources, we would conduct both the oncology and ocular programs simultaneously.

Our Experiments. The essential non-confidential information describing the scientific foundation of AngioGenex's proprietary technology and its experimental support is described in detail in the Patent Cooperation Treaty ("PCT")




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patent application (see Exhibit 99.1 to our Form 10 (the "Form 10") filed with the United States Securities and Exchange Commission (the "SEC") on August 22, 2017) and the following publication: "Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2 neu-dependent breast tumors" (de Candia et al, Proceedings of The National Academy of Sciences 2003). The aforementioned PCT patent application describes numerous experiments that produced the data supporting the patent claims. Additionally, the aforementioned publication describes experiments with a widely accepted model of breast cancer with experimental breast cancer prone "herceptin" mice.

The Path Forward. If we successfully complete the pre-clinical work, the next step will be the first human clinical testing of AGXA regarding safety and preliminary efficacy. To do so we will seek further financing or a corporate partner for the completion of testing and the ultimate marketing of the drug. Our goal is to achieve interim milestones toward FDA approval in a number of disease indications with distinct proprietary pharmaceutical products.

Financial History. As a research and development company, we have incurred significant losses since inception. We had an accumulated deficit of $7,738,379 as of June 30, 2019. These losses have resulted principally from costs incurred in connection with R&D activities, license fees and general and administrative expenses.



2. Financial Information


Overview


The Company's drugs (including our two lead drug candidates AGX51 and its derivative AGX51-?) are at the pre-clinical stage of development. Our Company would like to ultimately develop different Id-inhibitor drugs to treat cancer and macular degeneration. As a corporate strategy, the cancer program (i.e. AGX51) is on hold pending the receipt of sufficient resources or partnerships and we have determined to move first with the macular degeneration program (i.e. AGX51-?).

For AGX51, the estimated timeframe and cost for completion of pre-clinical work is approximately 15 to 18 months and approximately $1.5 million to $2 million so that we can file an IND and the estimated cost to complete Phase I/IIA clinical trials is approximately $12 million. For AGX51-?, the estimated timeframe and cost for completion of pre-clinical work is approximately 12 to 15 months and approximately $1.7 million so that we can file an IND and the estimated cost to complete Phase I/IIA clinical trials is approximately $8 million to $12 million.

We have limited financial resources and we will need to raise substantial additional funding in order to execute these plans. If we raise sufficient resources, we would conduct both the oncology and ocular programs simultaneously. However, there can be no assurance that such resources will be available or, if available, will be at rates or prices acceptable to us.

Comparison of Results of Operations for the Three Months ended June 30, 2019 and 2018

Revenues

We had no revenues for the three months ended June 30, 2019 and 2018.

Research and Development Expenses

For the three months ended June 30, 2019 and 2018, total research and development costs were $76,093 and $22,638, respectively. The increase is due to higher expenditures related to our continued research into the role of the Id genes and proteins, and its identification and development of molecules capable of inhibiting Id activity and preventing the neo-vascularization that supports the growth of cancerous tumors and characterizes other diseases including macular degeneration. The Company incurred $76,093 and $9,750 in connection with research performed at laboratories in the three months ended June 30, 2019 and 2018, respectively. The increase was offset by decrease in stock compensation from $12,888 for the three months ended June 30, 2018 to none for the three months ended June 30, 2019, as all of the compensation expense for unvested options has been recognized.




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General and Administrative Expenses

For the three months ended June 30, 2019 and 2018, total general and administrative expenses were $69,068 and $64,045, respectively. General and administrative expenses include professional fees for bookkeepers, auditors, and outside securities counsel who assisted with various aspects of the business and business development, and patent counsel fees and costs, including the maintenance of existing intellectual property. The increase is primarily due to an increase in professional fees.

We expect general and administrative expenses to increase overall through 2019 as we continue as a public reporting company. The non-recurring portions of the process of returning to a public reporting status are complete. We anticipate continued increased professional fee expenses associated with ongoing public reporting requirements and increased use of outside accounting and legal services for our continued operations and any financings.

Operating Loss

For the three months ended June 30, 2019, operating loss was $145,161 as compared with $86,683 for the three months ended June 30, 2018. The increase in operating loss is due to research and development costs, as described in "Research and Development Expenses" above, and to professional fees, which are described in "General and Administrative Expenses" above.

We expect to incur continued operating losses through 2019 as we continue to develop Id inhibitor drugs.

Interest Expense

Interest expense is comprised primarily of interest accrued on our debt. For the three months ended June 30, 2019, our interest expense was $2,146 as compared to $2,113 for the three months ended June 30, 2018.

Comparison of Results of Operations for the Six Months ended June 30, 2019 and 2018



Revenues


We had no revenues for the six months ended June 30, 2019 and 2018.

Research and Development Expenses

For the six months ended June 30, 2019 and 2018, total research and development costs were $170,511 and $12,266, respectively. The increase is due to higher expenditures related to our continued research into the role of the Id genes and proteins, and its identification and development of molecules capable of inhibiting Id activity and preventing the neo-vascularization that supports the growth of cancerous tumors and characterizes other diseases including macular degeneration. The Company incurred $167,678 and $15,582 in connection with research performed at laboratories in the six months ended June 30, 2019 and 2018, respectively. The increase is also due to a change in stock compensation from ($3,316) to $2,833 resulting from awards to a consultant that are accounted for as variable performance based option awards and are adjusted each reporting period. Stock-based compensation was negative for the six months ended June 30, 2018 due to the valuation of these contingent options.

General and Administrative Expenses

For the six months ended June 30, 2019 and 2018, total general and administrative expenses were $551,584 and $252,481, respectively. General and administrative expenses include professional fees for bookkeepers, auditors, and outside securities counsel who assisted with various aspects of the business and business development, and patent counsel fees and costs, including the maintenance of existing intellectual property. The increase is primarily due to the increase in stock compensation to officers and a director offset by a decrease in professional fees.

We expect general and administrative expenses to increase overall through 2019 as we continue as a public reporting company. The non-recurring portions of the process of returning to a public reporting status are complete. We anticipate continued increased professional fee expenses associated with ongoing public reporting requirements and increased use of outside accounting and legal services for our continued operations and any financings. Additionally, the Company may need to hire staff and increase overhead as it anticipates beginning clinical trials.




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Operating Loss

For the six months ended June 30, 2019, operating loss was $722,095 as compared with $264,747 for the six months ended June 30, 2018. The increase in operating loss is due to research and development costs, as described in "Research and Development Expenses" above, and to stock compensation to officers and a director offset by a decrease in professional fees, which are described in "General and Administrative Expenses" above.

We expect to incur continued operating losses through 2019 as we continue to develop Id inhibitor drugs.

Interest Expense

Interest expense is comprised primarily of interest accrued on our debt. For the six months ended June 30, 2019, our interest was $4,595 as compared to $5,095 for the six months ended June 30, 2018.

Liquidity and Capital Resources

We require significant additional cash resources to fund the expenditures necessary to maintain our operating infrastructure, to pay for research and development activities, and to pay our personnel and management team. Based on the Company's current cash usage expectations, management believes it will not have sufficient liquidity to fund its operations through September 2019. As we seek to further expand our pre-clinical and clinical programs and expand our intellectual property portfolio, we will need cash to fund such activities and enable in-licensing opportunities and other research and development endeavors.

The Company's significant development milestone is the filing of its first IND with the FDA for its lead drug candidate, AGX51-?, for the treatment of macular degeneration. Reaching the goal of the filing of the IND will require that the Company conduct animal toxicity studies in two separate species, a series of tests to determine how the drug is absorbed, distributed and cleared from the body, and a series of chemistry experiments to determine, among other things, the stability and shelf life of the drug. The Company has contracted with MSKCC to perform some or all of this work under a Pre-Clinical Service Agreement with MSKCC (see Exhibit 10.1 to our Form 10 filed with the SEC on August 22, 2017). A shift of focus from ocular to oncology product development, and combination therapy required additional in vivo preclinical experiments. We now anticipate interacting with the FDA in 2019 about an IND submission in 2020. The Company anticipates a total cost of approximately $1.7 million to accomplish this work in approximately 12 to18 months under the current agreement with MSKCC. The Company lacks all of the funding necessary to complete these tasks and will require additional capital to do so. The Company intends to obtain the funds necessary to complete the pre-clinical work needed to accomplish this significant milestone from new and existing investors and insiders.

We have historically relied on financing activities to provide the cash needed for our operating expenses. As of June 30, 2019, we had cash of $96,912.

Management believes that in order for the Company to meet its obligations arising from normal business operations through August 2020, the Company requires additional capital either in the form of a private placement of common stock or debt that will generate sufficient operating cash flows to fund operations.

Without such additional capital, our ability to operate will be limited and we may be unable to continue operations altogether. There can be no assurance that such equity or borrowings will be available or, if available, will be at rates or prices acceptable to us. These factors raise substantial doubt regarding our ability to continue as a going concern. Our unaudited consolidated financial statements have been prepared assuming we will continue as a going concern and do not include any adjustments that might be necessary should we be unable to continue as a going concern.



Operating Activities


Cash used for operating activities for the six months ended June 30, 2019 was $ 177,571 compared to $232,294 for the same period in 2018. The decrease is due to lower cash payments for research and development and professional fees associated with patent support and SEC filings in the current period.





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Financing Activities

Cash provided by financing activities for the six months ended June 30, 2019 was secured by the January 2019 issuance of 1,000,000 shares of common stock to a related party at $0.20 per share for proceeds of $200,000 and June 2019 subscription for 500,000 shares of common stock by a related party at $0.15 per share for proceeds of $75,000. No cash was provided by financing activities for the six months ended June 30, 2018. Cash used by financing activities for the six months ended June 30, 2019 comprised repayment of insurance financing of $16,015 and loan from related party of $4,085. Cash used by financing activities for the six months ended June 30, 2018 comprised repayment of a $10,000 note payable.

Off-Balance Sheet Arrangements

At June 30, 2019, we had no off-balance sheet arrangements.

Critical Accounting Policies, Judgments and Estimates

We have identified certain accounting policies that we believe are the most critical to the presentation of our financial information over a period of time. During the quarterly period ended June 30, 2019, there were no material changes to the critical accounting policies described in our 2018 Annual Report on Form 10-K. See Item 7, "Critical Accounting Policies, Judgments and Estimates" in our 2018 Annual Report on Form 10-K.

ITEM 3. Quantitative and Qualitative Disclosures about Market Risk

Market risk represents the risk of loss that may impact our financial position, results of operations, or cash flows due to adverse changes in financial and commodity market prices and rates. As of June 30, 2019, we do not believe we are exposed to significant market risks due to changes in United States interest rates or foreign currency exchange rates as measured against the United States dollar.



Inflation and Seasonality


We do not believe that our operations are significantly impacted by inflation. Our business is not seasonal in nature.

ITEM 4. Controls and Procedures

Evaluation of disclosure controls and procedures

Disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the "Exchange Act")) are designed to ensure that information required to be disclosed in reports filed or submitted under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in SEC rules and forms and that such information is accumulated and communicated to management, including the Chief Executive Officer and Chief Financial Officer, to allow timely decisions regarding required disclosures.

In connection with the preparation of this Form 10-Q, the Company's management, under the supervision of, and with the participation of, the Chief Executive Officer and Chief Financial Officer, conducted an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as of June 30, 2019. Our disclosure controls and procedures are designed to provide reasonable assurance that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms, and our management necessarily was required to apply its judgment in evaluating and implementing our disclosure controls and procedures. Based upon the evaluation described above, our Chief Executive Officer and Chief Financial Officer have concluded that, as of such date and subject to the discussion below, they believe that our disclosure controls and procedures are not effective and we have a material weakness, specifically in the calculation of stock based compensation.

Changes in Internal Control over Financial Reporting





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Our management, with the participation of the Chief Executive Officer and Chief Financial Officer, has evaluated whether any change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) occurred during the quarter ended June 30, 2019. Management concluded that no changes to our internal control over financial reporting occurred, other than the material weakness noted in the evaluation of disclosure controls and procedures above, during the quarter ended June 30, 2019 that have materially affected, or are reasonably likely to materially affect, our internal controls over financial reporting.




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                          PART II - OTHER INFORMATION

ITEM 1. Legal Proceedings

From time to time, we may be subject to legal proceedings and claims in the ordinary course of business. We currently have no material legal proceedings pending.



ITEM 1A. Risk Factors


Our operations and financial results are subject to various risks and uncertainties, including those described in Item 1A, "Risk Factors" in our 2018 Annual Report on Form 10-K, which could adversely affect our business, financial condition, results of operations, cash flows, and the trading price of our common and capital stock. During the quarterly period ended June 30, 2019, there were no material changes to the risk factors described in our 2018 Annual Report on Form 10-K.

ITEM 2. Unregistered Sales of Equity Securities and Use of Proceeds

None.

ITEM 3. Defaults Upon Senior Securities

None

ITEM 4. Mine Safety Disclosures



None.


ITEM 5. Other Information


None.


ITEM 6. Exhibits


        3.1   Articles of Incorporation**
        3.2   By-laws*
        10.1  Pre-Clinical Service Agreement between Memorial Sloan
              Kettering Cancer Center and AngioGenex Inc., dated February
              2, 2017*
        10.2  Agreement to transfer AngioGenex Inc. Stock to Memorial
              Sloan Kettering Cancer Center, dated April 11, 2014*
        16.1  Letter of Li & Company dated September 19, 2017**
        31.1  Rule 13a-14(a)/15d-14(a) Certification of Chief Executive
              Officer
        31.2  Rule 13a-14(a)/15d-14(a) Certification of Chief Financial
              Officer
        32.1  Section 1350 Certification of Chief Executive Officer
        32.2  Section 1350 Certification of Chief Financial Officer
        99.1  PCT patent application (WO 2015/08949 A2), published on
              June 18, 2015*
        101   The following materials from AngioGenex, Inc.'s Quarterly
              Report on Form 10-Q for the quarter ended June 30, 2019,
              formatted in XBRL (Extensible Business Reporting Language):
              (i) the Condensed Consolidated Balance Sheets, (ii) the
              Condensed Consolidated Statements of Operations, (iii) the
              Condensed Consolidated Statements of Cash Flows, (iv) the
              Condensed Consolidated Statement of Changes in
              Stockholders' Deficit and (v) Notes to Condensed
              Consolidated Financial Statements.
              *Previously filed together with our Form 10 submitted on
              August 22, 2017
              **Previously filed together with our Amendment No. 1 to our
              Form 10 submitted on September 19, 2017





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                                   SIGNATURES

Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized.



Dated: August 14, 2019ANGIOGENEX INC.


By: /s/ Robert BenezraRobert Benezra, Ph.D.,

Chief Executive Officer

(Principal Executive Officer)


By: /s/ Martin MurrayMartin Murray,

Chief Financial Officer

(Principal Financial and

Accounting Officer)




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