The benchmark index edged down 0.06 percent as several heavyweight stocks went ex-div: Old Mutual (>> Old Mutual plc), Schroders (>> Schroders plc), Smith & Nephew (>> Smith & Nephew plc), and Prudential (>> Prudential plc) fell between 1.2 percent and 1.7 percent.

However, the mining sector - boosted by strong metals prices - provided support. Glencore (>> Glencore PLC), Rio Tinto (>> Rio Tinto plc) and Anglo American (>> Anglo American plc) gained between 1 percent and 2.3 percent.

Also dragging on the FTSE, SSE (>> SSE PLC) shares fell 1.5 percent after the energy supplier said dividend cover for its 2017/18 financial year would be at the lower end of guidance.

The London Stock Exchange (>> London Stock Exchange Group Plc), fresh from disappointment over a planned merger with Deutsche Boerse being scuppered by the EU antitrust regulator, was up 0.8 percent.

"While a takeover of LSEG is not central to our positive thesis, we acknowledge that industry consolidation and the takeover potential should provide valuation support and is helpful to our positive thesis," RBC analysts said in a note, resuming coverage of the stock with an "outperform" rating.

Among other gainers, Ashtead (>> Ashtead Group plc) rose 2.4 percent after Liberum initiated coverage of the construction equipment rental company with a "buy", saying rental penetration in the U.S. market would drive growth for its North American segment, which contributes 86 percent of revenue.

"The upside potential from increased rental penetration in the U.S. market is yet to be fully reflected in Ashtead's share price, in our view," Liberum analysts said.

Among standout mid-cap movers, Petra Diamonds (>> Petra Diamonds Limited) surged 9.7 percent after it refinanced its debt, while RPC (>> RPC Group PLC) slumped 7.7 percent with one trader saying a lack of detail over its guidance disappointed investors.

Small-cap Carr's Group (>> Carr's Group PLC) dropped 17 percent, its worst losses for 16 years after the agriculture and engineering firm cut its expectations for full-year performance.

Analysts said the market was waiting for Britain to set out its plan for converting EU laws into domestic law in a White Paper later on Thursday, and EU Council President Donald Tusk to give negotiating guidelines to the 27 member states by Friday.

Investors called for a renewed focus on fundamentals ahead of the long Brexit process.

"We have got a minimum of two years, and realistically much longer, to figure out how it all falls into place," said Ian Williams, economics and strategy analyst at Peel Hunt.

"We are in completely uncharted territory, many things can change. So from an equity standpoint all you can do is take a step back and look at your companies, and at the macro picture."

(Additional reporting by Danilo Masoni; Editing by Louise Ireland)

By Helen Reid