LONDON--(BUSINESS WIRE)--

FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser: Barclays PLC.
(b) Owner or controller of interest and short
positions disclosed, if different from 1(a):
(c) Name of offeror/offeree in relation to whose TAKEDA PHARMACEUTICAL CO LTD
relevant securities this form relates:
(d) If an exempt fund manager connected with an
offeror/offeree, state this and specify identity of
offeror/offeree:
(e) Date position held/dealing undertaken: 14 August 2018
(f) In addition to the company in 1(c) above, is the discloser making YES:
disclosures in respect of any other party to the offer? SHIRE PLC

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: ORD
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 15,809,010 1.99% 15,686,662 1.97%
(2) Cash-settled derivatives:
15,250,390 1.92% 14,094,400 1.77%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 13,623,700 1.71% 14,043,700 1.77%
TOTAL: 44,683,100 5.62% 43,824,762 5.51%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
ORD Purchase 48 4,581.7292 JPY
ORD Purchase 100 4,574.2000 JPY
ORD Purchase 353 4,599.7705 JPY
ORD Purchase 357 4,595.2717 JPY
ORD Purchase 396 4,598.9520 JPY
ORD Purchase 400 4,585.5000 JPY
ORD Purchase 427 4,609.1967 JPY
ORD Purchase 500 4,574.0000 JPY
ORD Purchase 521 4,604.0000 JPY
ORD Purchase 800 4,623.5000 JPY
ORD Purchase 993 4,602.8429 JPY
ORD Purchase 1,000 4,590.7000 JPY
ORD Purchase 1,400 4,584.2142 JPY
ORD Purchase 1,700 4,609.0588 JPY
ORD Purchase 2,000 4,594.2250 JPY
ORD Purchase 2,400 4,596.8333 JPY
ORD Purchase 2,823 4,624.3485 JPY
ORD Purchase 3,400 4,586.5294 JPY
ORD Purchase 4,582 4,600.2436 JPY
ORD Purchase 4,600 4,579.4347 JPY
ORD Purchase 5,100 4,578.8235 JPY
ORD Purchase 5,200 4,606.2048 JPY
ORD Purchase 5,300 4,579.2264 JPY
ORD Purchase 5,400 4,588.3240 JPY
ORD Purchase 7,100 4,582.3408 JPY
ORD Purchase 7,700 4,581.1428 JPY
ADS Purchase 24,667 20.6047 USD
ORD Purchase 27,400 4,588.5036 JPY
ORD Purchase 30,000 4,576.6166 JPY
ORD Purchase 80,900 4,592.6650 JPY
ORD Purchase 104,200 4,595.5470 JPY
ORD Purchase 134,500 4,600.3851 JPY
ORD Purchase 372,100 4,598.0373 JPY
ORD Sale 200 4,609.5000 JPY
ORD Sale 200 4,584.0000 JPY
ORD Sale 400 4,589.9000 JPY
ORD Sale 400 4,585.5000 JPY
ADS Sale 500 20.6380 USD
ORD Sale 500 4,574.0000 JPY
ORD Sale 800 4,622.7500 JPY
ORD Sale 800 4,586.7500 JPY
ORD Sale 1,000 4,590.7000 JPY
ORD Sale 1,500 4,620.8000 JPY
ORD Sale 1,700 4,609.0588 JPY
ORD Sale 2,000 4,594.2250 JPY
ORD Sale 2,600 4,586.3846 JPY
ORD Sale 3,100 4,587.0000 JPY
ORD Sale 4,600 4,579.4347 JPY
ORD Sale 4,900 4,578.1224 JPY
ORD Sale 5,000 4,588.1980 JPY
ORD Sale 7,100 4,622.4366 JPY
ORD Sale 7,200 4,582.2277 JPY
ORD Sale 11,000 4,626.1272 JPY
ORD Sale 13,500 4,588.9925 JPY
ADS Sale 24,667 20.6047 USD
ORD Sale 28,600 4,600.3706 JPY
ORD Sale 33,400 4,577.6257 JPY
ORD Sale 47,800 4,589.4707 JPY
ORD Sale 132,800 4,598.6423 JPY
ORD Sale 373,700 4,596.9526 JPY

(b) Cash-settled derivative transactions

Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
ORD CFD Long 11,300 4,635.7488 JPY
ORD SWAP Short 7 4,577.9577 JPY
ORD SWAP Short 41 4,575.2054 JPY
ORD SWAP Short 48 4,581.7602 JPY
ORD SWAP Short 79 4,586.0893 JPY
ORD SWAP Short 121 4,604.0016 JPY
ORD SWAP Short 169 4,613.1831 JPY
ORD SWAP Short 174 4,587.3920 JPY
ORD SWAP Short 184 4,587.4535 JPY
ORD SWAP Short 247 4,586.1808 JPY
ORD SWAP Short 316 4,597.8774 JPY
ORD SWAP Short 317 4,602.1589 JPY
ORD SWAP Short 420 4,589.2458 JPY
ORD SWAP Short 420 4,609.7162 JPY
ORD SWAP Short 819 4,606.1264 JPY
ORD SWAP Short 2,403 4,630.4839 JPY
ORD SWAP Short 4,335 4,601.0451 JPY
ORD SWAP Short 5,200 4,606.2049 JPY

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security Product description e.g. call option Writing, purchasing, selling, varying etc. Number of securities to which option relates Exercise price per unit Type

e.g. American, European etc.

Expiry date Option money paid/ received per unit

(ii) Exercise

Class of relevant security Product description

e.g. call option

Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached? YES
Date of disclosure: 15 Aug 2018
Contact name: Large Holdings Regulatory Operations
Telephone number: 020 3134 7213

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

143221.01

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Identity of the person whose positions/dealings Barclays PLC.
are being disclosed:
Name of offeror/offeree in relation to whose TAKEDA PHARMACEUTICAL CO LTD
relevant securities this from relates:

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
ORD Put Options Purchased -39,000 5781.0000 European 14 Dec 2018
ORD Call Options Purchased 48,000 4625.0000 European 12 Oct 2018
ORD Call Options Purchased 40,000 6182.0000 European 14 Dec 2018
ORD Call Options Purchased 39,000 5781.0000 European 14 Dec 2018
ORD Call Options Written -78,000 5781.0000 European 14 Dec 2018
ORD Call Options Written -460,000 6182.0000 European 14 Dec 2018
ORD Put Options Purchased -13,200,000 4799.0427 European 5 Sep 2018
ORD Put Options Written 13,200,000 4799.0427 European 5 Sep 2018
ORD Call Options Purchased 13,200,000 4799.0427 European 5 Sep 2018
ORD Call Options Written -104,700 5065.8300 European 17 Apr 2019
ORD Put Options Written 104,700 5065.8300 European 17 Apr 2019
ORD Put Options Purchased -48,000 4625.0000 European 12 Oct 2018
ORD Put Options Written 78,000 5781.0000 European 14 Dec 2018
ORD Put Options Written 114,000 4750.0200 European 14 May 2019
ORD Call Options Written -114,000 4750.0200 European 14 May 2019
ORD Call Options Written -13,200,000 4799.0427 European 5 Sep 2018

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20180815005343/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Barclays plc published this content on 15 August 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 15 August 2018 12:30:08 UTC