Cosmo Pharmaceuticals Announces Cassiopea’s Very Positive Top-Line Phase 3 Results for Winlevi® (Clascoterone) in Treating Acne

Cosmo Pharmaceuticals Announces Cassiopea's Very Positive Top-Line Phase 3 Results for Winlevi® (Clascoterone) in Treating Acne

Dublin - July 10, 2018 - Cosmo Pharmaceuticals N.V. (SIX: COPN) today announced that Cassiopea, a clinical-stage specialty pharmaceutical company focused on developing medical dermatology products of which Cosmo holds a 45% stake, today announced that top line results from two pivotal phase 3 clinical trials for its topical anti-androgen Winlevi® (Clascoterone) demonstrated highly statistically significant improvements for all primary clinical end points.

"We are extremely happy about these outstanding trial results," said Alessandro Della Chà, Chief Executive Officer of Cosmo Pharmaceuticals. "The development team of Cosmo has worked for Cassiopea since inception, this is a great success for both companies. If approved, Winlevi® has the potential to become an outstanding drug. I am thankful to all, whose relentless work has generated such an outcome."

About Cosmo Pharmaceuticals

Cosmo is a specialty pharmaceutical company that aims to become a global leader in the field of optimized therapies for selected gastrointestinal disorders. The company's proprietary clinical development pipeline specifically addresses innovative treatments for IBD, such as Ulcerative Colitis and Crohn's Disease, and Colon Infections. In addition, the Company has developed Eleview™, a medical device for polyp excision and is developing Methylene Blue MMX®, a product for the detection of colon cancer and has a large shareholding in Cassiopea S.p.A., a clinical-stage specialty pharmaceutical company focused on developing and commercializing innovative and differentiated medical dermatology products. Cosmo's MMX® products that have reached the market are Lialda®/Mezavant®/Mesavancol®, a treatment for Ulcerative Colitis that is licensed globally to Nogra and Shire Limited and Uceris®, the first glucocorticosteroid indicated for the induction of remission in active, mild to moderate Ulcerative Colitis, licensed in the USA to Santarus/Salix/Valeant and in the Rest of the World to Ferring. Cosmo's proprietary MMX® technology is at the core of the Company's product pipeline and was developed from its expertise in formulating and manufacturing gastrointestinal drugs for international clients at its GMP (Good Manufacturing Practice) facilities in Lainate, Italy. The technology is designed to deliver active ingredients in a targeted manner in the colon. For further information on Cosmo, please visit the Company's website: www.cosmopharma.com

Financial Calendar

Half-Year Results

July 26, 2018

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Disclaimer

Some of the information contained in this press release contains forward-looking statements. Readers are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, and that actual results may differ materially from those in the forward-looking statements as a result of various factors. Cosmo undertakes no obligation to publicly update or revise any forward-looking statements.

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