HYPERA S.A.

Publicly-Held Company

Corporate Taxpayer ID CNPJ/MF No. 02.932.074/0001-91

Company Registry (NIRE) 35.300.353.251

CVM Code No. 21431

NOTICE TO THE MARKET

HYPERA ("Company" or "Hypera Pharma") hereby informs that, pursuant to the provisions of article 12 of CVM Instruction 358/02, has received a notice from Mondrian Investment Partners Limited ("Mondrian") regarding the reduction of equity interests in the Company. Mondrian informed that manages 31,362,420 (thirty one million, three hundred and sixty two thousand, four hundred and twenty) common shares of the Company, corresponding to approximately 4.96% of its capital stock.

Additionally, we inform that, according to the same notice, Mondrian and its affiliates currently do not intend to acquire control or to change the management structure of the Company.

Enclosed herewith is the letter sent by Mondrian.

São Paulo, October 24th, 2018.

HYPERA S.A.

Adalmario Ghovatto Satheler do Couto

Investor Relations Officer

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Hypera SA published this content on 24 October 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 24 October 2018 20:47:04 UTC