Innate Pharma : Written questions to the Annual General Meeting

Q&A

WRITTEN QUESTIONS TO THE ANNUAL GENERAL MEETING OF

MAY 19, 2020

1. In a recent interview of Pr. Raoult on the French television (BFM TV), he was asked to comment on avdoralimab in theCOVID-19 and implied that the Marseille Hospitals provided avdoralimab in compassionate use, before the French drugs authority (ANSM) allowed the FORCE trial. How many patients were involved? What was observed?

Avdoralimab was not provided on a compassionate-use basis in the COVID-19.

1. Imcheck Therapeutics was created a few days after the announcement of your collaboration with thePaoli-Calmettes Institute and Daniel Olive in July 2015. For their works, they use your product, IPH1101 (BrHPP), on a regular basis. Does Innate Pharma earn any income or has any future advantage on these works? What are your industrial and/or equity links with this company?

BrHPP is a research reagent that is commercially available or accessible through chemical synthesis. The Company has terminated the license on the patents protecting this component and its use in 2013, when IPH1101 development was stopped.

Neither is there equity nor industrial links between the Company and Imcheck Therapeutics.

1. Recent information found online, especially on the Korean FDA website, suggests that the monalizumab Phase III in relapsed head and neck cancer will be formalized in the near future. Is an accelerated approval in 2nd/3rd line, based on the PFS of cohort 2 and 3, still possible?

The Company announced that AstraZeneca will advance monalizumab into a Phase III randomized clinical trial evaluating monalizumab in combination with cetuximab in patients suffering from recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) who have been previously exposed to an immune checkpoint inhibitor (IO-pretreated). From a methodological standpoint, a development that comprises a Phase II followed by a registrational Phase III is the most standard approach to clinical development.

It is too early to comment on details regarding a program stemming from cohort 3. This cohort relates to IO-naïve SCCHN patients. Preliminary data is expected for the second half of 2020. Also, it is a first-line development in which a standard of care exists. A registrational Phase III would be necessary for any approval in this indication.

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Q&A

Disclaimer:

The answers to these questions contain certain forward-looking statements, including those within the meaning of the Private Securities Litigation Reform Act of 1995.The use of certain words, including "believe," "potential," "expect" and "will" and similar expressions, is intended to identify forward-looking statements. Although the company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, progression of and results from its ongoing and planned clinical trials and preclinical studies, review and approvals by regulatory authorities of its product candidates, the Company's commercialization efforts, the Company's continued ability to raise capital to fund its development and the overall impact of the COVID-19 outbreak on the global healthcare system as well as the Company's business, financial condition and results of operations. For an additional discussion of risks and uncertainties which could cause the company's actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors ("Facteurs de Risque") section of the Universal Registration Document filed with the French Financial Markets Authority ("AMF"), which is available on the AMF website http://www.amf-france.orgor on Innate Pharma's website,and public filings and reports filed with the U.S. Securities and Exchange Commission ("SEC"), including the Company's Annual Report on Form 20-F for the year ended December 31, 2019, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public, by the Company.

The answer to these questions and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares in Innate Pharma in any country.

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