Regulatory News:

Lysogene (FR0013233475 – LYS) (Paris:LYS), a pioneering Phase 3 biopharmaceutical company specializing in gene therapy targeting central nervous system (CNS) diseases, presents the report of its liquidity contract with Gilbert Dupont.

As of 31 December 2019, the following assets were held in the liquidity account:

  • Number of shares: 35,929
  • Cash balance: €66,297.87

During the second semester of 2019, the following was negotiated:

BUY   146 707 shares   €254 727.37   886 transactions
SELL   152 571 shares   €267 808.78   862 transactions

As a reminder, at the date of the previous half-year report on 28 June 2019, the following assets were held in the liquidity account:

  • Number of shares: 41,793
  • Cash balance: €53 216.46

As a reminder, at the time of the implementation of the liquidity contract, the following assets were held in the liquidity account:

  • Number of shares: 0
  • Cash balance: €300,000.00

About Lysogene

Lysogene is a gene therapy company focused on the treatment of orphan diseases of the central nervous system (CNS). The company has built a unique capability to enable a safe and effective delivery of gene therapies to the CNS to treat lysosomal diseases and other genetic disorders of the CNS. A pivotal clinical trial in MPS IIIA in partnership with Sarepta Therapeutics, Inc. is ongoing and a phase 1-2 clinical trial in GM1 Gangliosidosis is in preparation. In accordance with the agreements signed between Lysogene and Sarepta Therapeutics, Inc., Sarepta Therapeutics, Inc. will hold exclusive commercial rights to LYS-SAF302 in the United States and markets outside Europe; and Lysogene will maintain commercial exclusivity of LYS-SAF302 in Europe. Lysogene is also collaborating with an academic partner to define the strategy of development for the treatment of Fragile X syndrome, a genetic disease related to autism. www.lysogene.com.

Forward Looking Statement

This press release may contain certain forward-looking statements, especially on the Company’s progress of its phase 2-3 clinical trial and cash runway. Although the Company believes its expectations are based on reasonable assumptions, all statements other than statements of historical fact included in this press release about future events are subject to (i) change without notice, (ii) factors beyond the Company’s control, (iii) clinical trial results, (iv) increased manufacturing costs and (v) potential claims on its products. These statements may include, without limitation, any statements preceded by, followed by or including words such as “target,” “believe,” “expect,” “aim,” “intend,” “may,” “anticipate,” “estimate,” “plan,” “objective”, “project,” “will,” “can have,” “likely,” “should,” “would,” “could” and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company’s control that could cause the Company’s actual results, performance or achievements to be materially different from the expected results, performance or achievements expressed or implied by such forward-looking statements. A further list and description of these risks, uncertainties and other risks can be found in the Company’s regulatory filings with the French Autorité des Marchés Financiers, including in the 2018 registration document (Document de référence), registered with the French Markets Authorities on April 29, 2019, under number R. 19-016, and future filings and reports by the Company. Furthermore, these forward-looking statements are only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future. If the Company updates one or more forward-looking statements, no inference should be drawn that it will or will not make additional updates with respect to those or other forward-looking statements.

This press release has been prepared in both French and English. In the event of any differences between the two texts, the French language version shall supersede.

APPENDIX 2nd HALF 2019

  BUY   SELL
    Number of transactions   Number of shares   Amount in EUR   Number of transactions   Number of shares   Amount

in EUR

TOTAL   886   146 707   254 727.37   862   152 571   267 808.78
01/07/2019   6   2000   3897.6   3   418   812.97
02/07/2019   2   539   1035.9   5   499   966.61
03/07/2019   0   0   0   4   1039   2022.21
04/07/2019   4   800   1549.04   0   0   0
05/07/2019   4   288   560.3   12   4569   9005.96
08/07/2019   3   460   913.61   4   1500   2997.45
09/07/2019   10   1430   2775.49   2   460   895.39
10/07/2019   0   2053   3998.83   0   1703   3364.62
11/07/2019   2   221   430.73   0   0   0
12/07/2019   0   0   0   2   260   507.81
15/07/2019   1   210   412.65   8   1772   3523.09
16/07/2019   8   1460   2882.92   0   0   0
17/07/2019   5   592   1160.2   3   692   1366.42
18/07/2019   4   881   1727.82   3   360   711.04
19/07/2019   3   300   594   0   0   0
22/07/2019   2   230   454.09   1   160   316
23/07/2019   16   3398   6582.61   1   500   985
24/07/2019   6   672   1254.49   2   450   842.49
25/07/2019   1   104   197.6   8   1605   3131.84
26/07/2019   1   100   192   3   90   173.14
29/07/2019   4   307   582.78   1   103   197.25
30/07/2019   0   0   0   3   357   678.16
31/07/2019   2   756   1447.74   1   7   13.48
01/08/2019   5   381   722.64   0   0   0
02/08/2019   1   2   3.76   1   1   1.9
05/08/2019   14   1627   3033.22   1   2   3.73
06/08/2019   7   933   1712.15   1   2   3.68
07/08/2019   0   0   0   1   110   202.95
08/08/2019   2   217   399.84   0   0   0
09/08/2019   5   671   1225.45   2   103   190
12/08/2019   3   305   554.19   1   10   18.2
13/08/2019   11   2081   3663.81   2   1069   1938.74
14/08/2019   7   867   1482.66   10   1355   2348.35
15/08/2019   11   1074   1809.37   1   5   8.7
16/08/2019   10   861   1446.31   1   10   17
19/08/2019   5   204   337.6   1   130   215.8
20/08/2019   3   180   296.1   0   0   0
21/08/2019   12   787   1287.14   10   771   1270.22
22/08/2019   2   4   6.56   5   309   507.97
23/08/2019   0   0   0   6   533   884.03
26/08/2019   0   0   0   3   1217   2034.09
27/08/2019   5   652   1084.8   3   220   373.6
28/08/2019   0   0   0   3   304   506.16
29/08/2019   1   100   166   0   0   0
30/08/2019   3   203   332.41   4   206   339.96
02/09/2019   4   475   782.99   1   15   24.98
03/09/2019   2   250   408.5   1   120   197.4
04/09/2019   4   620   1014.32   3   310   508.4
05/09/2019   12   1837   2926.16   3   361   570.09
06/09/2019   10   1041   1772.09   22   3555   6022.53
09/09/2019   2   250   420   3   102   171.87
10/09/2019   5   845   1388.5   0   0   0
11/09/2019   3   455   746.2   4   361   594.64
12/09/2019   0   0   0   6   729   1211.45
13/09/2019   12   2190   3597.95   4   758   1242.97
16/09/2019   5   1117   1828.86   7   2843   4765.72
17/09/2019   5   1208   1966.87   11   2618   4334.36
18/09/2019   5   513   926.02   24   6397   11426.96
19/09/2019   5   1350   2509.52   7   1505   2835.12
20/09/2019   6   1110   2116.33   12   2416   4648.38
23/09/2019   0   0   0   12   2887   5653.32
24/09/2019   4   1200   2340.96   1   1   1.95
25/09/2019   21   4780   9023.68   0   0   0
26/09/2019   2   324   603.64   0   0   0
27/09/2019   8   1536   2824.4   0   0   0
30/09/2019   8   1350   2399.22   5   533   963.45
01/10/2019   1   100   181.5   13   1935   3532.54
02/10/2019   8   1116   2016.61   5   900   1671.48
03/10/2019   0   0   0   5   560   1022.45
04/10/2019   5   536   972.46   0   0   0
07/10/2019   5   884   1568.75   0   0   0
08/10/2019   4   550   968   0   0   0
09/10/2019   10   2592   4465.76   0   0   0
10/10/2019   1   45   76.05   4   250   428.75
11/10/2019   1   115   198.38   0   0   0
14/10/2019   12   2299   3850.37   2   300   517.95
15/10/2019   3   1103   1819.95   6   613   1020.95
16/10/2019   7   992   1636.7   2   950   1596
17/10/2019   3   1000   1617.5   5   821   1330.02
18/10/2019   2   33   54.8   8   1226   2024.25
21/10/2019   9   1696   2811.29   0   0   0
22/10/2019   7   1148   1860.22   8   1432   2344.76
23/10/2019   3   460   747.5   2   400   652
24/10/2019   3   481   778.07   2   339   554.27
25/10/2019   9   2003   3205.6   0   0   0
28/10/2019   4   1060   1672.68   7   1787   2829.54
29/10/2019   4   295   474.12   19   3185   5185.82
30/10/2019   2   490   796.79   2   200   329
31/10/2019   2   499   810.08   4   900   1485
01/11/2019   3   320   519.39   3   810   1323.38
04/11/2019   6   676   1089.51   7   1088   1797.81
05/11/2019   6   694   1151.76   3   700   1165.78
06/11/2019   6   1012   1678.71   1   290   485.75
07/11/2019   5   363   718.05   55   11748   23916.58
08/11/2019   40   6971   14017.98   12   735   1490.36
11/11/2019   22   2932   5400.45   22   3968   7516.98
12/11/2019   18   2527   4920.83   8   802   1583.55
13/11/2019   23   3091   5723.91   20   3005   5642.49
14/11/2019   0   3900   6739.98   0   0   0
15/11/2019   19   2051   3342.51   22   2289   3780.51
18/11/2019   5   511   822.91   11   942   1575.97
19/11/2019   11   985   1584.67   13   1788   2910.15
20/11/2019   8   986   1570.7   23   3847   6363.71
21/11/2019   3   221   361.29   3   135   224.3
22/11/2019   3   315   522.9   3   310   520.8
25/11/2019   10   1175   1936.99   7   1791   2990.07
26/11/2019   12   1950   3166.8   13   3092   5086.65
27/11/2019   6   1410   2310   3   1111   1839.93
28/11/2019   6   1000   1598   2   565   912.31
29/11/2019   7   1345   2130.61   3   250   398
02/12/2019   7   1220   1919.91   3   275   435.88
03/12/2019   24   3514   5491.33   19   5281   8486.04
04/12/2019   8   2458   3797.61   6   390   608.79
05/12/2019   24   5774   8562.84   25   6633   10064.25
06/12/2019   14   2460   3779.3   32   2722   4259.66
09/12/2019   13   2152   3299.66   6   1550   2389.95
10/12/2019   5   1092   1678.73   13   2748   4299.52
11/12/2019   10   1576   2484.25   17   3772   6011.06
12/12/2019   1   350   570.5   5   1370   2241.46
13/12/2019   5   678   1102.63   10   1598   2618.48
16/12/2019   4   1040   1729   22   3371   5736.09
17/12/2019   18   2369   4051.7   1   7   12.01
18/12/2019   13   2659   4375.92   10   968   1644.15
19/12/2019   14   2866   4838.09   27   5212   9057.41
20/12/2019   18   2342   4008.57   21   2602   4510.57
23/12/2019   24   4349   7509.85   30   6099   10660.44
24/12/2019   13   1733   3091.33   0   0   0
27/12/2019   8   1115   1961.73   18   2222   3968.94
30/12/2019   6   654   1164.45   6   875   1607.9
31/12/2019   19   1973   3608.22   15   1400   2596.72

APPENDIX 1st HALF 2019

  BUY   SELL
    Number of transactions   Number of shares   Amount in EUR   Number of transactions   Number of shares   Amount in

EUR

TOTAL   863   136 453   277 531.68   762   135 515   275 240.21
02/01/2019   6   1250   2013   19   2411   3921.25
03/01/2019   4   889   1442.49   11   2135   3556.7
04/01/2019   1   10   17.05   1   171   292.41
07/01/2019   9   826   1401.31   2   400   683
08/01/2019   8   699   1186.41   8   826   1418.82
09/01/2019   9   923   1557.19   12   981   1679.08
10/01/2019   5   474   814.9   0   0   0
11/01/2019   20   2559   4211.35   9   1313   2170.26
14/01/2019   6   489   817.66   2   392   661.85
15/01/2019   1   80   134.4   2   113   190.41
16/01/2019   5   669   1126.53   1   250   421.25
17/01/2019   11   1269   2104.38   7   1576   2622.15
18/01/2019   5   325   543.14   0   0   0
21/01/2019   1   83   137.78   0   0   0
22/01/2019   1   50   83.25   5   700   1172.5
23/01/2019   8   758   1261.08   4   1420   2382.19
24/01/2019   3   321   539.06   6   741   1248.81
25/01/2019   0   0   0   13   1469   2548.86
28/01/2019   24   3212   5571.21   12   1125   1994.51
29/01/2019   2   131   226.79   12   2440   4290.74
30/01/2019   4   410   733.9   0   0   0
31/01/2019   6   645   1140.3   0   0   0
01/02/2019   0   0   0   4   165   291.37
04/02/2019   18   2194   3749.33   3   197   343.17
05/02/2019   4   215   356.26   3   206   342.48
06/02/2019   3   242   404.02   2   76   126.93
07/02/2019   0   0   0   0   0   0
08/02/2019   1   90   151.2   3   214   359.99
11/02/2019   5   421   716.63   21   2985   5221.96
12/02/2019   10   1497   2547.74   2   125   215.63
13/02/2019   1   10   17.05   6   468   799.62
14/02/2019   0   0   0   13   1421   2471.69
15/02/2019   20   2194   3995.27   24   2741   5118.54
18/02/2019   22   2517   4604.1   22   2622   4877.71
19/02/2019   5   1001   1857.76   11   1588   2970.04
20/02/2019   4   854   1612.61   7   1137   2155.98
21/02/2019   0   0   0   33   4465   9195.22
22/02/2019   19   2662   5565.18   11   2241   4738.82
25/02/2019   9   1991   4764.26   17   2985   7296.24
26/02/2019   14   3122   7302.67   7   2470   5852.42
27/02/2019   17   3140   7232.36   8   2660   6157.9
28/02/2019   14   2559   5803.81   2   654   1497.66
01/03/2019   6   1179   2648.86   6   1022   2319.94
04/03/2019   7   1915   4418.29   13   3129   7314.04
05/03/2019   6   620   1384.03   2   200   454
06/03/2019   8   1089   2448.94   0   0   0
07/03/2019   7   3027   6896.11   23   6587   15298.31
08/03/2019   1   300   720   7   1231   3025.43
11/03/2019   12   2391   5596.37   14   1639   3916.23
12/03/2019   27   2945   6918.1   7   1259   3017.07
13/03/2019   9   2018   4591.15   8   687   1582.44
14/03/2019   13   2218   5045.73   12   2292   5365.57
15/03/2019   6   502   1189.34   4   697   1679.77
18/03/2019   5   762   1780.03   1   107   252.52
19/03/2019   8   508   1192.78   4   685   1618.79
20/03/2019   13   2476   5747.79   5   691   1623.02
21/03/2019   17   2524   5855.43   2   10   23.21
22/03/2019   8   1917   4416.19   4   817   1921.18
25/03/2019   5   1001   2259.26   3   140   316.69
26/03/2019   2   350   791   8   2376   5461.71
27/03/2019   8   2090   4746.18   2   70   159.6
28/03/2019   12   2700   6063.66   4   854   1923.98
29/03/2019   4   1250   2762.5   1   70   156.1
01/04/2019   0   0   0   7   2363   5345.34
02/04/2019   6   850   1922.53   1   600   1362
03/04/2019   8   1890   4212.81   0   0   0
04/04/2019   1   500   1100   1   200   442
05/04/2019   2   254   564.92   7   1747   3905.77
08/04/2019   4   850   1876.46   0   0   0
09/04/2019   8   1896   4065.78   9   2338   5095.9
10/04/2019   7   1122   2477.04   6   1196   2662.54
11/04/2019   9   1497   3320.8   4   1614   3599.87
12/04/2019   8   2246   4946.59   0   0   0
15/04/2019   6   650   1408.03   2   113   245.21
16/04/2019   3   515   1112.76   2   100   218
17/04/2019   9   1274   2727.12   0   0   0
18/04/2019   11   1263   2624.14   3   110   228.9
19/04/2019   0   0   0   0   0   0
23/04/2019   0   0   0   8   2702   5809.03
24/04/2019   1   250   537.5   2   352   761.34
25/04/2019   4   430   919.3   0   0   0
26/04/2019   2   70   154.4   21   4548   10154.32
29/04/2019   2   250   557.5   2   210   478.8
30/04/2019   16   1679   3618.08   1   50   107.5
02/05/2019   0   0   0   5   509   1099.44
03/05/2019   2   150   322.5   10   1700   3761.93
06/05/2019   11   1080   2276.1   0   0   0
07/05/2019   7   1450   2898.99   2   111   222.68
08/05/2019   11   1719   3344.49   2   411   804.08
09/05/2019   6   1002   1917.93   0   0   0
10/05/2019   1   48   90.72   9   1879   3636.99
13/05/2019   12   2746   5037.26   2   219   415.49
14/05/2019   4   950   1698.98   7   2150   3929.56
15/05/2019   8   1217   2165.77   3   590   1056.16
16/05/2019   0   0   0   2   314   564.16
17/05/2019   11   1376   2422.17   2   300   537
20/05/2019   6   1250   2183.5   4   298   520.28
21/05/2019   3   287   498.35   4   313   547.12
22/05/2019   5   400   696.8   3   478   840.23
23/05/2019   18   3247   5349.11   14   3266   5452.91
24/05/2019   4   1104   1843.68   20   4298   7555.45
27/05/2019   5   547   964.74   4   836   1508.23
28/05/2019   1   200   386   17   3466   6714.34
29/05/2019   6   1000   1973.8   14   2709   5504.96
30/05/2019   7   1100   2200.77   1   113   227.13
31/05/2019   20   3884   7576.91   4   802   1605.04
03/06/2019   3   486   952.56   2   301   591.89
04/06/2019   1   255   499.8   3   190   373.77
05/06/2019   0   0   0   8   1438   2867.52
06/06/2019   6   525   1048.74   1   2   4
07/06/2019   9   2076   4044.05   0   0   0
10/06/2019   7   802   1572.96   7   1020   2011.44
11/06/2019   2   299   587.54   4   948   1889.93
12/06/2019   4   741   1483.63   18   3293   6678.2
13/06/2019   4   1274   2533.86   6   542   1090.45
14/06/2019   7   775   1554.11   4   534   1095.61
17/06/2019   10   2250   4414.95   0   0   0
18/06/2019   14   2253   4262   11   2052   3908.24
19/06/2019   10   1472   2765.15   10   2362   4480.24
20/06/2019   3   400   761.24   5   1119   2170.3
21/06/2019   5   768   1469.18   4   758   1463.32
24/06/2019   6   960   1833.6   11   2455   4892.32
25/06/2019   2   500   990   1   500   1000
26/06/2019   8   517   1025.78   2   400   795.52
27/06/2019   4   641   1275.4   3   1150   2300
28/06/2019   14   2653   5247.63   2   1000   1990