2019 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at Daily Asia Business -- Current study results on Chemistry - Organic Chemistry have been published. According to news reporting out of Saitama, Japan, by NewsRx editors, research stated, “Ligand-dependent Suzuki cross-coupling of 4-bromopyrazol-5-yl triflates has been developed. This approach enabled selective introduction of an aryl substituent at the C4 or C5 position in pyrazoles.”
Our news journalists obtained a quote from the research from Mitsubishi Tanabe Pharma America Inc., “This protocol is the first example in which the cross-coupling proceeded predominantly at the C4 position in pyrazoles, which is generally recognized as the least reactive position. The selection of phosphine ligands switched the order of arylation.”
According to the news editors, the research concluded: “This method should be highly useful for preparing diverse poly-substituted pyrazole derivatives.”
For more information on this research see: Ligand-Dependent Site-Selective Suzuki Cross-Coupling of 4-Bromopyrazol-5-yl Triflates. The Journal of Organic Chemistry, 2019;():. The Journal of Organic Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA.
Our news journalists report that additional information may be obtained by contacting R. Sakakibara, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda, Saitama 335-8505, Japan. Additional authors for this research include K. Itoh and H. Fujii.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1021/acs.joc.9b01306. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Publisher contact information for the The Journal of Organic Chemistry is: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA.
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