By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Oncology - Chronic Lymphocytic Leukemia have been presented. According to news reporting originating from Marlborough, Massachusetts, by NewsRx correspondents, research stated, "The prognostic role of cytogenetic analysis is well-established in B-cell chronic lymphocytic leukemia (CLL). Approximately 80% of patients have a cytogenetic aberration."
Our news editors obtained a quote from the research from Quest Diagnostics, "Interphase FISH panels have been the gold standard for cytogenetic evaluation, but conventional cytogenetics allows detection of additional abnormalities, including translocations, complex karyotypes and multiple clones. Whole genome copy number assessment, currently performed by chromosomal microarray analysis (CMA), is particularly relevant in CLL for the following reasons: (1) copy number alterations (CNAs) represent key events with biologic and prognostic significance; (2) DNA from fresh samples is generally available; and (3) the tumor burden tends to be relatively high in peripheral blood. CMA also identifies novel copy number variants and copy-neutral loss-of-heterozygosity (CN-LOH), and can refine deletion breakpoints. The Cancer Genomics Consortium (CGC) Working Group for CLL has performed an extensive literature review to describe the evidence-based clinical utility of CMA in CLL."
According to the news editors, the research concluded: "We provide suggestions for the integration of CMA into clinical use and list recurrent copy number alterations, regions of CN-LOH and mutated genes to aid in interpretation."
For more information on this research see: Assessing copy number aberrations and copy-neutral loss-of-heterozygosity across the genome as best practice: An evidence-based review from the Cancer Genomics Consortium (CGC) working group for chronic lymphocytic leukemia. Cancer Genetics, 2018;228-229():236-250. Cancer Genetics can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Cancer Genetics - www.journals.elsevier.com/cancer-genetics/)
The news editors report that additional information may be obtained by contacting P.M. Miron, Quest Diagnost, Marlborough, MA 01752, United States. Additional authors for this research include G.D. Wenger, A. Chaubey, D.P. Dash, R. Kanagal-Shamanna, S. Kantarci, R. Kolhe, D.L. Van Dyke, L. Wang, D.J. Wolff and K. Chun (see also Oncology - Chronic Lymphocytic Leukemia).
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.cancergen.2018.07.004. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
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