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MarketScreener Homepage  >  Equities  >  Nasdaq  >  Regeneron Pharmaceuticals    REGN

REGENERON PHARMACEUTICALS (REGN)
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Regeneron Pharmaceuticals : New Rheumatoid Arthritis Study Findings Have Been Reported by Researchers at Regeneron Pharmaceuticals Inc. (Patient-reported outcomes from a...

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07/12/2018 | 07:19pm CEST

New Rheumatoid Arthritis Study Findings Have Been Reported by Researchers at Regeneron Pharmaceuticals Inc. (Patient-reported outcomes from a randomized phase III trial of sarilumab monotherapy versus adalimumab monotherapy in patients with ...)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Autoimmune Diseases and Conditions - Rheumatoid Arthritis. According to news reporting originating in Tarrytown, New York, by NewsRx journalists, research stated, "The phase III MONARCH randomized controlled trial (NCT02332590) demonstrated that in patients with rheumatoid arthritis (RA), sarilumab (anti-interleukin-6 receptor monoclonal antibody) monotherapy is superior to adalimumab monotherapy in reducing disease activity and signs and symptoms of RA, as well as in improving physical function, with similar rates of adverse and serious adverse events. We report the effects of sarilumab versus adalimumab on patient-reported outcomes (PROs)."

The news reporters obtained a quote from the research from Regeneron Pharmaceuticals Inc., "Patients with active RA intolerant of, or inadequate responders to, methotrexate were randomized to sarilumab 200 mg plus placebo every 2 weeks (q2w; n = 184) or adalimumab 40 mg plus placebo q2w (n = 185). Dose escalation to weekly administration of adalimumab or matching placebo was permitted at week 16. PROs assessed at baseline and weeks 12 and 24 included patient global assessment of disease activity (PtGA), pain and morning stiffness visual analogue scales (VASs), Health Assessment Questionnaire Disability Index (HAQ-DI), 36-item Short Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Rheumatoid Arthritis Impact of Disease (RAID), and rheumatoid arthritis-specific Work Productivity Survey (WPS-RA). Between-group differences in least-squares mean (LSM) changes from baseline were analyzed. p< 0.05 was considered significant for PROs in a predefined hierarchy. For PROs not in the hierarchy, nominal p values are provided. Proportions of patients reporting improvements greater than or equal to the minimal clinically important difference (MCID) and achieving normative values were assessed. At week 24, sarilumab treatment resulted in significantly greater LSM changes from baseline than adalimumab monotherapy in HAQ-DI (p < 0.005), PtGA (p < 0.001), pain VAS (p < 0.001), and SF-36 Physical Component Summary (PCS) (p < 0.001). Greater LSM changes were reported for sarilumab than for adalimumab in RAID (nominal p< 0.001), morning stiffness VAS (nominal p< 0.05), and WPS-RA (nominal p< 0.005). Between-group differences in FACIT-F and SF-36 Mental Component Summary (MCS) were not significant. More patients reported improvements greater than or equal to the MCID in HAQ-DI (nominal p< 0.01), RAID (nominal p< 0.01), SF-36 PCS (nominal p< 0.005), and morning stiffness (nominal p< 0.05), as well as greater than or equal to the normative values in HAQ-DI (p < 0.05), with sarilumab versus adalimumab."

According to the news reporters, the research concluded: "In parallel with the clinical efficacy profile previously reported, sarilumab monotherapy resulted in greater improvements across multiple PROs than adalimumab monotherapy."

For more information on this research see: Patient-reported outcomes from a randomized phase III trial of sarilumab monotherapy versus adalimumab monotherapy in patients with rheumatoid arthritis. Arthritis Research & Therapy, 2018;20():14-25. Arthritis Research & Therapy can be contacted at: Bmc, Campus, 4 Crinan St, London N1 9XW, England. (BioMed Central - www.biomedcentral.com/; Arthritis Research & Therapy - arthritis-research.com/)

Our news correspondents report that additional information may be obtained by contacting C.I. Chen, Regeneron Pharmaceut Inc., Tarrytown, NY 10591, United States. Additional authors for this research include L. Gossec, C.W.J. Proudfoot, V. Strand, M. Reaney, S. Guillonneau, T. Kimura, J. van Adelsberg, Y. Lin, E.K. Mangan, H. van Hoogstraten and G.R. Burmester (see also Autoimmune Diseases and Conditions - Rheumatoid Arthritis).

Keywords for this news article include: Tarrytown, New York, United States, North and Central America, Musculoskeletal Diseases and Conditions, Tumor Necrosis Factor (TNF) Inhibitors, Healthcare Biotechnology Companies, Autoimmune Diseases and Conditions, Joint Diseases and Conditions, Biopharmaceutical Companies, Clinical Trials and Studies, Monoclonal Antibodies, Rheumatoid Arthritis, Drugs and Therapies, Health and Medicine, Immunologic Agents, Adalimumab Therapy, Clinical Research, Sarilumab Therapy, Pharmaceuticals, Antirheumatics, Immunotherapy, Business, Placebos, Regeneron Pharmaceuticals Inc.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC

(c) 2018 NewsRx LLC, source Health Newsletters

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Financials ($)
Sales 2018 6 441 M
EBIT 2018 2 710 M
Net income 2018 1 857 M
Finance 2018 3 553 M
Yield 2018 -
P/E ratio 2018 22,07
P/E ratio 2019 20,83
EV / Sales 2018 5,85x
EV / Sales 2019 5,00x
Capitalization 41 219 M
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Mean consensus HOLD
Number of Analysts 25
Average target price 406 $
Spread / Average Target 4,6%
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Managers
NameTitle
Leonard S. Schleifer Co-President, Chief Executive Officer & Director
George Damis Yancopoulos Co-President, Director & Chief Scientific Officer
P. Roy Vagelos Chairman
Robert E. Landry Chief Financial Officer & Senior VP-Finance
Michael S. Brown Independent Director
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