Log in
E-mail
Password
Remember
Forgot password ?
Become a member for free
Sign up
Sign up
Settings
Settings
Dynamic quotes 
OFFON

MarketScreener Homepage  >  Equities  >  Swiss Exchange  >  Roche Holding Ltd.    ROG   CH0012032048

ROCHE HOLDING LTD. (ROG)
My previous session
Most popular
  Report  
SummaryQuotesChartsNewsAnalysisCalendarCompanyFinancialsConsensusRevisions 
News SummaryMost relevantAll newsOfficial PublicationsSector newsTweets
OFFRE

Roche : Trastuzumab Treatment for HER-2-Expressing Tumors Need Not Delay Breast Reconstruction Following Mastectomy

share with twitter share with LinkedIn share with facebook
share via e-mail
0
10/04/2017 | 02:04pm CEST

CHICAGO, Oct. 3 -- The American College of Surgeons issued the following news release:

Treatment with trastuzumab (Herceptin/Genentech) of breast cancers that express the HER-2 protein does not increase the risk for complications at the surgical site for women who undergo immediate breast reconstruction after mastectomy. The first study to assess the effect of trastuzumab on surgical wound complications indicates that breast reconstruction need not be delayed because of the type or length of this form of adjuvant therapy. (Adjuvant therapy is treatment that is given in addition to the primary or main form of treatment to maximize effectiveness.) Study results appear as an "article in press" on the Journal of the American College of Surgeons website in advance of print.

However, combination therapy involving trastuzumab and pertuzumab (Perjeta/Genentech) may carry an increased risk for wound complications after immediate breast reconstruction. Therefore, authors of the study advise surgeons and patients to consider delaying breast reconstruction in otherwise high-risk patients until completion of the full course of treatment if pertuzumab is added to the neoadjuvant regimen. "If a patient is otherwise fairly healthy and the surgery is straightforward, immediate breast reconstruction may be done even if she is receiving both therapies. If a patient has other risk factors and faces a potentially difficult operation, I would recommend waiting until the completion of pertuzumab therapy," said Scott Hollenbeck, MD, FACS, principal author of the study and a plastic and reconstructive surgeon at Duke University Medical Center, Durham, N.C.

Twenty percent of invasive breast cancers have tumors that express the growth factor protein HER-2. These tumors tend to grow and spread more rapidly than other forms of breast cancer.1

Trastuzumab is a monoclonal antibody that targets the HER-2 protein. When given in conjunction with conventional chemotherapy, trastuzumab has increased overall survival, 10-year survival, and disease-free survival of patients with HER-2+ breast cancer.1

Pertuzumab is also used in the treatment of HER-2+ breast tumors. The monoclonal antibody was approved in 2012 for combination therapy with trastuzumab to treat the small number of patients with HER-2-expressing tumors that have metastasized, were larger than 2 cm, involved lymph nodes, or were inflammatory or locally advanced. The addition of pertuzumab to trastuzumab and chemotherapy has prolonged survival for patients with metastatic disease.2

The concern for surgeons who perform breast reconstruction after mastectomy is whether suppression of the HER-2 protein affects the integrity of the skin and therefore increases a patient's susceptibility for wound infection or breakdown at the surgical site. "During surgical reconstruction of the breast after mastectomy, the skin is saved and an implant or flap is inserted underneath. If the skin doesn't heal or dies, the reconstruction could fail and require another operation. Trastuzumab and pertuzumab block the action of HER-2, which is associated with the epidermis or outer layer of the skin. Up to now, there haven't been any studies of the outcomes after breast reconstruction in patients who received these agents. We conducted this study to determine whether trastuzumab alone or in combination with pertuzumab negatively affected breast reconstruction outcomes," Dr. Hollenbeck said.

Investigators at Duke University identified all patients who had breast reconstruction after mastectomy between 2006 and 2016. Of the total of 481 women, the researchers compared outcomes in two matched groups of 107 patients. One group received trastuzumab with or without pertuzumab; the other did not. Patients were matched by age, obesity, diabetes, tobacco use, and type of oncologic treatment regimen.

Overall, the rate of wound breakdown that required a return to surgery for treatment was higher in patients who received both trastuzumab and pertuzumab. The use of trastuzumab alone was not associated with any complication at the surgical site, including bleeding, swelling, coagulation or clotting, disruption of the layers of skin around the surgical incision, or cellular death in the mastectomy skin flap.

"At the present time, there are no clear clinical guidelines on the optimal timing for breast reconstruction. While preliminary, this study may be helpful for guiding the decision by patients and surgeons," Dr. Hollenbeck said.

Findings from the study need to be validated in larger, prospective studies. Until then, the study results "may help surgeons feel more comfortable performing immediate breast reconstruction on patients who receive trastuzumab and delaying the surgery for those on combination targeted HER-2 treatment," he concluded.

Other study authors are Ronnie L. Shammas, BS; Eugenia H. Cho, BSc; Adam D. Glener, BS; Luke P. Poveromo, BS; Lily R. Mundy, MD; Rachel A. Greenup, MD, MPH; and Kimberly L. Blackwell, MD.

"FACS" designates that a surgeon is a Fellow of the American College of Surgeons.

Citation: Association between Targeted HER-2 Therapy and Breast Reconstruction Outcomes: A Propensity-Matched Analysis. Journal of American College of Surgeons: http://www.journalacs.org/article/S1072-7515(17)31928-2/abstract

Foot notes:-

1. Perez EA et al. Trastuzumab plus adjuvant chemotherapy for human EGF receptor 2 positive breast cancer: Planned joint analysis of overall survival from HSABP B-31 and NCCTG N 9831. J Clin Oncol, 32 (33), Nov 2014; 3744-3752.

2. Swain SMS et al. Pertuzumab, trastuzumab, and docetaxel in HER 2-positive metastasis breast cancer. N Engl J Med 2015 Feb 19; 372 (8): 724-34.

Targeted News Service, source News Service

share with twitter share with LinkedIn share with facebook
share via e-mail
0
Latest news on ROCHE HOLDING LTD.
09/21AbbVie Gets Positive CHMP Opinion for Combination of Venclyxto With Rituximab..
DJ
09/13Roche Works to Fill Sales Gap as Biosimilars Emerge -Reuters
DJ
09/13Roche steps up efficiency drive to take sting out of biosimilars
RE
09/13ROCHE : FDA Approves Subcutaneous Formulation of Actemra for Use in Active Syste..
BU
09/13ROCHE : boss says Brexit and curbs on drug use pose threat to UK science
RE
09/10U.K. Health Regulator Rejects Roche's MS Drug
DJ
09/10ROCHE : faces UK pricing row over multiple sclerosis drug Ocrevus
RE
09/06FDA Extends Review Period for Roche Cancer Treatment License
DJ
09/06GENENTECH : to Present New Data from Its Extensive Lung Cancer Program at the 20..
BU
09/04With drugs pipeline in focus, Bayer considers job cuts
RE
More news
News from SeekingAlpha
08:26aSTOCKS TO WATCH : Calling Up Animal Spirits 
09/21Key events next week - healthcare 
09/21New opinions from EMA advisor CHMP 
09/20Arvinas Holding Prepares Terms For $100 Million IPO 
09/18Roche launches two NAVIFY clinical decision support apps 
Financials (CHF)
Sales 2018 56 475 M
EBIT 2018 19 233 M
Net income 2018 12 946 M
Debt 2018 4 708 M
Yield 2018 3,74%
P/E ratio 2018 15,54
P/E ratio 2019 15,24
EV / Sales 2018 3,67x
EV / Sales 2019 3,52x
Capitalization 203 B
Chart ROCHE HOLDING LTD.
Duration : Period :
Roche Holding Ltd. Technical Analysis Chart | MarketScreener
Full-screen chart
Technical analysis trends ROCHE HOLDING LTD.
Short TermMid-TermLong Term
TrendsBearishBullishNeutral
Income Statement Evolution
Consensus
Sell
Buy
Mean consensus OUTPERFORM
Number of Analysts 27
Average target price 259  CHF
Spread / Average Target 10%
EPS Revisions
Managers
NameTitle
Severin Schwan Chief Executive Officer & Executive Director
Christoph Franz Chairman
Alan Hippe Chief Financial & Information Technology Officer
John Irving Bell Non-Executive Director
Andreas Oeri Independent Non-Executive Director
Sector and Competitors
1st jan.Capitalization (M$)
ROCHE HOLDING LTD.-4.60%211 501
JOHNSON & JOHNSON1.62%383 312
PFIZER21.65%258 285
NOVARTIS-0.63%216 108
MERCK AND COMPANY25.79%189 092
AMGEN17.94%132 756