Shanghai Fosun Pharmaceutical : OVERSEAS REGULATORY ANNOUNCEMENT - Announcement in Relation to Acceptance of New Drug Application Filing from Fosun Kite Biotechnology Co., Ltd.

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上 海 復 星 醫 藥（ 集 團 ）股 份 有 限 公 司

Shanghai Fosun Pharmaceutical (Group) Co., Ltd.*

(a joint stock limited company incorporated in the People's Republic of China with limited liability)

(Stock Code: 02196)

OVERSEAS REGULATORY ANNOUNCEMENT

This announcement is made pursuant to Rule 13.10B of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited.

The following sets out the ''Announcement in Relation to Acceptance of New Drug Application Filing from Fosun Kite Biotechnology Co., Ltd.*'' published by Shanghai Fosun Pharmaceutical (Group) Co., Ltd. (the ''Company'') on the website of the Shanghai Stock Exchange, for your reference only. The following is a translation of the abovementioned announcement solely for the purpose of providing information. Should there be any discrepancies, the Chinese version will prevail.

By order of the Board

Shanghai Fosun Pharmaceutical (Group) Co., Ltd.*

Chen Qiyu

Chairman

Shanghai, the People's Republic of China

24 February 2020

As at the date of this announcement, the executive directors of the Company are Mr. Chen Qiyu, Mr. Yao Fang and Mr. Wu Yifang; the non-executive directors of the Company are Mr. Xu Xiaoliang, Mr. Wang Can, Ms. Mu Haining and Mr. Liang Jianfeng; and the independent non-executive directors of the Company are Mr. Jiang Xian, Dr. Wong Tin Yau Kelvin, Ms. Li Ling and Mr. Tang Guliang.

• for identification purposes only

Stock code: 600196	Stock abbreviation: Fosun Pharma Annoucement No.:2020-014
Stock code: 136236 Bond abbreviation: 16Fosun01
Stock code: 143020 Bond abbreviation: 17Fosun01
Stock code: 143422	Bond abbreviation: 18Fosun01
Stock code: 155067	Bond abbreviation: 18Fosun02
Stock code: 155068	Bond abbreviation: 18Fosun03

Shanghai Fosun Pharmaceutical (Group) Co., Ltd.*

Announcement in Relation to

Acceptance of New Drug Application Filing from

Fosun Kite Biotechnology Co., Ltd.*

The board of directors (the "Board") of the Company and all members of the Board warrant that this announcement does not contain any false information, misleading statement or material omission, and severally and jointly accept full responsibility for the truthfulness, accuracy and completeness of the contents herein contained.

I. Overview

Recently, Fosun Kite Biotechnology Co., Ltd.* (復星凱特生物科技有限公司) ("Fosun Kite"; as at the date of the annoucement, Shanghai Fosun Pharmaceutical Industrial Development Company Limited* (上海復星醫藥產業發展有限公司), a subsidiary of the Company, holding 50% of its share), a joint venture of Shanghai Fosun Pharmaceutical (Group) Co., Ltd.* (the "Company"), has received the Acceptance Notice number CXSS2000006 Guo for Axicabtagene Ciloleucel (i.e. anti-humanCD19-directedCAR-T cell injection, the "Product") for the treatment of adult patients with relapsed and refractory large B-cell lymphoma (including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma (PMBCL), high-gradeB-cell lymphoma and DLBCL arising from follicular lymphoma) from the National Medical Products Administration (the "NMPA") for review of its marketing registration.

II. General Information on the Acceptance Notice

Product name: Axicabtagene Ciloleucel (code: FKC876, anti-humanCD19-directedCAR-T cell injection)

Acceptance no.: CXSS2000006 Guo

Prticulars of application: New Drug Application: Special approval procedure; Other additional application items

Applicant: Fosun Kite Biotechnology Co., Ltd*

Conclusion: Acceptance

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III. Research Progress of the Product

The Product is the autologous CD19-directedCAR-T cell therapy YESCARTA® of Kite Pharma, Inc. ("Kite Pharma", a controlling subsidiary of Gilead Sciences, Inc.) in the United States for the treatment of adult patients with relapsed and refractory large B-cell lymphoma (including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma (PMBCL), high-gradeB-cell lymphoma and DLBCL arising from follicular lymphoma). In October 2017, YESCARTA® was approved for marketing in the United States by the U.S. Food and Drug Administration (FDA); it is the world's first approved CAR-T cell therapy for adult patients with certain types of non-Hodgkin lymphoma (NHL). In August 2018 it was approved for marketing in Europe by the European Medicines Agency (EMA).

Fosun Kite initiated the technology transfer of YESCARTA® from Kite Pharma, and obtained technical and commercial rights in mainland China, Hong Kong SAR and Macau SAR, and proposed to carry out localized production in PRC(excluding Hong Kong and Macau SAR and Taiwan Region, similarly hereinafter). In August 2018, the Product obtained the Investigational New Drug (IND) approval from NMPA. As at the date of this announcement, the bridging clinical trial of the Product for the treatment of adult patients with relapsed and refractory large B-cell lymphoma has been completed in PRC.

As at the date of this announcement, no same-class drug with the same target has been approved for marketing in PRC. The other CAR-T product has been approved by FDA so far is KYMRIAH® of Novartis Pharma Schweiz AG, which has the same target CD19 as Fosun Kite's FKC876 for the treatment of acute lymphoblastic leukemia in children and young adults (aged between 2 and 25) and relapsed/refractory large B-cell lymphoma (including diffuse large B-cell lymphoma, transformed follicular lymphoma and primary mediastinal B-cell lymphoma) in adults. According to the financial reports announced by Gilead Sciences, Inc. and Novartis Pharma Schweiz AG, sales of YESCARTA® and KYMRIAH® in 2019 amounted to approximately US$456 million and US$278 million, respectively.

As of January 2020, the cumulative R&D investment of Fosun Kite for the Product was approximately RMB474 million (including patent and technology license fee, unaudited) at this stage.

IV. Risk Warning

The new drug is subject to obtaining NDA approval and GMP certification before its commercial production can be carried out. The acquisition of the Acceptance Notice at this time will not have a material impact on the results of the current period of the Group (the Company and its subsidiaries).

Due to the characteristics of pharmaceutical industry, the production of various products/drugs and the specific sales volume after production in the future may be affected by factors including changes in market conditions with great uncertainties. Investors are reminded of the investment risks.

Announcement is hereby given.

Board of Shanghai Fosun Pharmaceutical (Group) Co., Ltd.

24 February 2020

* for identification purposes only

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