LONDON--(BUSINESS WIRE)--

FORM 8.3

Amendment to Purchases

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser: Barclays PLC.
(b) Owner or controller of interest and short
positions disclosed, if different from 1(a):
(c) Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this form relates:
(d) If an exempt fund manager connected with an
offeror/offeree, state this and specify identity of
offeror/offeree:
(e) Date position held/dealing undertaken: 12 December 2018
(f) In addition to the company in 1(c) above, is the discloser making YES:
disclosures in respect of any other party to the offer? TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 13,572,038 1.48% 8,214,753 0.90%
(2) Cash-settled derivatives:
186,222 0.02% 6,674,884 0.73%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 1,079,300 0.12% 935,200 0.10%
TOTAL: 14,837,560 1.62% 15,824,837 1.73%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
5p ordinary Purchase 28 45.4836 GBP
5p ordinary Purchase 41 45.3250 GBP
5p ordinary Purchase 58 45.4650 GBP
5p ordinary Purchase 66 45.3800 GBP
5p ordinary Purchase 67 45.5225 GBP
5p ordinary Purchase 67 45.4775 GBP
5p ordinary Purchase 67 45.4575 GBP
5p ordinary Purchase 67 45.4550 GBP
5p ordinary Purchase 67 45.4475 GBP
5p ordinary Purchase 67 45.4975 GBP
5p ordinary Purchase 67 45.5025 GBP
5p ordinary Purchase 67 45.4750 GBP
5p ordinary Purchase 67 45.4150 GBP
5p ordinary Purchase 90 45.4725 GBP
5p ordinary Purchase 100 45.3850 GBP
5p ordinary Purchase 101 45.4250 GBP
5p ordinary Purchase 111 45.4350 GBP
5p ordinary Purchase 113 45.4450 GBP
5p ordinary Purchase 146 45.3900 GBP
5p ordinary Purchase 173 45.4950 GBP
5p ordinary Purchase 208 45.3200 GBP
5p ordinary Purchase 213 45.4881 GBP
5p ordinary Purchase 252 45.4230 GBP
5p ordinary Purchase 328 45.3744 GBP
5p ordinary Purchase 455 45.3856 GBP
5p ordinary Purchase 513 45.3300 GBP
5p ordinary Purchase 595 45.4457 GBP
5p ordinary Purchase 641 45.5230 GBP
5p ordinary Purchase 998 45.4052 GBP
5p ordinary Purchase 1,035 45.3748 GBP
5p ordinary Purchase 1,263 45.4227 GBP
5p ordinary Purchase 1,327 45.3506 GBP
5p ordinary Purchase 1,450 45.4000 GBP
5p ordinary Purchase 1,865 45.4373 GBP
5p ordinary Purchase 2,378 45.4799 GBP
5p ordinary Purchase 3,086 45.3437 GBP
5p ordinary Purchase 4,390 45.4639 GBP
5p ordinary Purchase 4,503 45.4473 GBP
5p ordinary Purchase 4,534 45.4400 GBP
5p ordinary Purchase 12,253 45.3922 GBP
5p ordinary Purchase 13,806 45.4080 GBP
5p ordinary Purchase 13,870 45.4272 GBP
5p ordinary Purchase 16,086 45.4369 GBP
5p ordinary Purchase 19,514 45.4333 GBP
5p ordinary Purchase 23,378 45.4071 GBP
5p ordinary Purchase 27,007 45.4500 GBP
5p ordinary Purchase 30,920 45.4266 GBP
5p ordinary Purchase 43,254 45.4345 GBP
5p ordinary Purchase 45,671 45.4576 GBP
5p ordinary Purchase 50,000 45.5354 GBP
5p ordinary Purchase 50,000 45.4954 GBP
5p ordinary Purchase 68,512 45.4633 GBP
5p ordinary Purchase 100,000 45.5530 GBP
5p ordinary Purchase 192,147 45.4293 GBP
5p ordinary Sale 9 45.5275 GBP
5p ordinary Sale 41 45.3250 GBP
5p ordinary Sale 58 45.4650 GBP
5p ordinary Sale 66 45.3800 GBP
5p ordinary Sale 67 45.4550 GBP
5p ordinary Sale 67 45.4575 GBP
5p ordinary Sale 67 45.4150 GBP
5p ordinary Sale 67 45.4775 GBP
5p ordinary Sale 67 45.4975 GBP
5p ordinary Sale 67 45.5025 GBP
5p ordinary Sale 67 45.5225 GBP
5p ordinary Sale 67 45.4475 GBP
5p ordinary Sale 67 45.4750 GBP
5p ordinary Sale 90 45.4725 GBP
5p ordinary Sale 100 45.4000 GBP
5p ordinary Sale 100 45.3850 GBP
5p ordinary Sale 101 45.4250 GBP
5p ordinary Sale 111 45.4350 GBP
5p ordinary Sale 113 45.4450 GBP
5p ordinary Sale 144 45.4400 GBP
5p ordinary Sale 146 45.3900 GBP
5p ordinary Sale 173 45.4950 GBP
5p ordinary Sale 190 45.3386 GBP
5p ordinary Sale 208 45.3200 GBP
5p ordinary Sale 326 45.3543 GBP
5p ordinary Sale 344 45.4363 GBP
5p ordinary Sale 568 45.4726 GBP
5p ordinary Sale 631 45.6165 GBP
5p ordinary Sale 709 45.3466 GBP
5p ordinary Sale 949 45.3828 GBP
5p ordinary Sale 998 45.4052 GBP
5p ordinary Sale 1,103 45.4674 GBP
5p ordinary Sale 1,137 45.3480 GBP
5p ordinary Sale 1,176 45.4077 GBP
5p ordinary Sale 1,294 45.3909 GBP
5p ordinary Sale 1,539 45.5006 GBP
5p ordinary Sale 1,889 45.4495 GBP
5p ordinary Sale 2,785 45.4581 GBP
5p ordinary Sale 3,542 45.5211 GBP
5p ordinary Sale 3,973 45.4751 GBP
5p ordinary Sale 4,004 45.4464 GBP
5p ordinary Sale 4,503 45.4473 GBP
5p ordinary Sale 5,702 45.4387 GBP
5p ordinary Sale 6,450 45.5347 GBP
5p ordinary Sale 10,645 45.4627 GBP
5p ordinary Sale 12,874 45.3593 GBP
5p ordinary Sale 13,806 45.4080 GBP
5p ordinary Sale 14,941 45.4500 GBP
5p ordinary Sale 17,460 45.4541 GBP
5p ordinary Sale 18,848 45.5539 GBP
5p ordinary Sale 20,104 45.4273 GBP
5p ordinary Sale 24,208 45.4623 GBP
5p ordinary Sale 34,640 45.4970 GBP
5p ordinary Sale 51,647 45.4678 GBP
5p ordinary Sale 95,538 45.4064 GBP
5p ordinary Sale 120,000 45.4727 GBP
5p ordinary Sale 2,179,572 45.5499 GBP
ADR Purchase 10 172.6200 USD
ADR Purchase 88 171.7100 USD
ADR Purchase 98 172.4800 USD
ADR Purchase 100 172.7600 USD
ADR Purchase 100 171.9450 USD
ADR Purchase 100 171.9100 USD
ADR Purchase 100 171.8500 USD
ADR Purchase 100 172.7800 USD
ADR Purchase 149 172.6253 USD
ADR Purchase 197 172.7000 USD
ADR Purchase 200 172.8100 USD
ADR Purchase 251 172.5203 USD
ADR Purchase 300 171.8066 USD
ADR Purchase 307 172.4142 USD
ADR Purchase 400 172.5800 USD
ADR Purchase 400 172.5850 USD
ADR Purchase 521 172.4610 USD
ADR Purchase 596 172.8432 USD
ADR Purchase 900 172.5855 USD
ADR Purchase 1,513 172.2262 USD
ADR Purchase 2,116 172.3577 USD
ADR Purchase 2,947 172.5912 USD
ADR Purchase 5,413 172.5354 USD
ADR Purchase 5,531 172.4656 USD
ADR Purchase 6,800 172.4655 USD
ADR Purchase 7,122 172.3991 USD
ADR Purchase 7,600 172.4866 USD
ADR Sale 61 172.5700 USD
ADR Sale 100 171.9450 USD
ADR Sale 100 172.6000 USD
ADR Sale 186 172.7676 USD
ADR Sale 200 172.3200 USD
ADR Sale 300 172.4766 USD
ADR Sale 300 172.5500 USD
ADR Sale 300 172.5466 USD
ADR Sale 350 172.4257 USD
ADR Sale 399 172.4965 USD
ADR Sale 400 172.7506 USD
ADR Sale 400 172.3600 USD
ADR Sale 596 172.8432 USD
ADR Sale 1,100 172.5200 USD
ADR Sale 1,298 172.4800 USD
ADR Sale 1,398 172.1420 USD
ADR Sale 1,400 172.6635 USD
ADR Sale 2,368 172.4246 USD
ADR Sale 3,500 172.5182 USD
ADR Sale 4,100 172.4596 USD
ADR Sale 4,587 172.3813 USD
ADR Sale 7,300 172.4841 USD
ADR Sale 13,028 172.5011 USD

(b) Cash-settled derivative transactions

Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
5p ordinary CFD Long 85 45.4809 GBP
5p ordinary SWAP Long 269 45.4966 GBP
5p ordinary CFD Long 437 45.4893 GBP
5p ordinary SWAP Long 774 45.4114 GBP
5p ordinary CFD Long 851 45.4271 GBP
5p ordinary CFD Long 1,103 45.4674 GBP
5p ordinary CFD Long 1,404 45.4500 GBP
5p ordinary CFD Long 3,561 45.3308 GBP
5p ordinary CFD Long 3,973 45.4751 GBP
5p ordinary CFD Long 4,773 45.4639 GBP
5p ordinary CFD Long 5,350 45.4591 GBP
5p ordinary CFD Long 5,702 45.4387 GBP
5p ordinary CFD Long 5,983 45.3963 GBP
5p ordinary CFD Long 12,874 45.3593 GBP
5p ordinary CFD Long 20,104 45.4273 GBP
5p ordinary SWAP Long 23,764 45.4000 GBP
5p ordinary SWAP Long 45,732 45.4090 GBP
5p ordinary SWAP Long 49,655 45.4779 GBP
5p ordinary CFD Long 90,000 45.3375 GBP
5p ordinary CFD Short 28 45.4835 GBP
5p ordinary SWAP Short 385 45.4434 GBP
5p ordinary SWAP Short 540 45.4020 GBP
5p ordinary CFD Short 2,334 45.4040 GBP
5p ordinary SWAP Short 3,989 45.4362 GBP
5p ordinary SWAP Short 29,162 45.4134 GBP
ADR CFD Short 30,000 170.5620 USD
5p ordinary SWAP Short 32,005 45.4566 GBP
5p ordinary CFD Short 50,000 45.4954 GBP
5p ordinary CFD Short 50,000 45.5354 GBP
5p ordinary CFD Short 100,000 45.5530 GBP
5p ordinary CFD Short 192,147 45.4293 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class Product Writing, Number Exercise Type Expiry Option
of description purchasing, of price date money
relevant selling, securities per unit paid/
security varying etc to which received
option per unit
relates
ADR Call Options Purchasing 1,000 170 USD American 18 Jan 2019 6.2000 USD
ADR Put Options Purchasing 300 170 USD American 18 Jan 2019 3.3000 USD
ADR Put Options Purchasing 400 170 USD American 18 Apr 2019 6.8000 USD

(ii) Exercise

Class of relevant security Product description

e.g. call option

 Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

 Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached? YES
Date of disclosure: 14 Dec 2018
Contact name: Large Holdings Regulatory Operations
Telephone number: 020 3134 7213

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Identity of the person whose positions/dealings Barclays PLC.
are being disclosed:
Name of offeror/offeree in relation to whose SHIRE
relevant securities this from relates:

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
5p ordinary Call Options Written -125,000 3600.0000 American 21 Dec 2018
5p ordinary Put Options Written 125,000 3600.0000 American 21 Dec 2018
ADR Call Options Purchased 100 180.0000 American 18 Apr 2019
ADR Call Options Purchased 100 190.0000 American 4 Jan 2019
ADR Call Options Purchased 100 155.0000 American 15 Jan 2021
ADR Call Options Purchased 100 140.0000 American 18 Jan 2019
ADR Call Options Purchased 100 105.0000 American 18 Jan 2019
ADR Call Options Purchased 100 110.0000 American 17 Jan 2020
ADR Call Options Purchased 100 195.0000 American 19 Jul 2019
ADR Call Options Purchased 100 220.0000 American 18 Jan 2019
ADR Call Options Purchased 200 135.0000 American 17 Jan 2020
ADR Call Options Purchased 200 175.0000 American 18 Jan 2019
ADR Call Options Purchased 200 155.0000 American 17 Jan 2020
ADR Call Options Purchased 200 130.0000 American 17 Jan 2020
ADR Call Options Purchased 200 210.0000 American 18 Jan 2019
ADR Call Options Purchased 200 160.0000 American 17 Jan 2020
ADR Call Options Purchased 200 120.0000 American 17 Jan 2020
ADR Call Options Purchased 300 115.0000 American 18 Jan 2019
ADR Call Options Purchased 300 165.0000 American 18 Jan 2019
ADR Call Options Purchased 400 170.0000 American 17 Jan 2020
ADR Call Options Purchased 400 230.0000 American 18 Jan 2019
ADR Call Options Purchased 500 165.0000 American 18 Apr 2019
ADR Call Options Purchased 500 150.0000 American 18 Jan 2019
ADR Call Options Purchased 900 180.0000 American 21 Dec 2018
ADR Call Options Purchased 900 195.0000 American 18 Apr 2019
ADR Call Options Purchased 1,000 185.0000 American 19 Jul 2019
ADR Call Options Purchased 1,000 190.0000 American 11 Jan 2019
ADR Call Options Purchased 1,000 135.0000 American 18 Jan 2019
ADR Call Options Purchased 1,000 180.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 170.0000 American 19 Jul 2019
ADR Call Options Purchased 1,500 230.0000 American 15 Jan 2021
ADR Call Options Purchased 1,700 195.0000 American 17 Jan 2020
ADR Call Options Purchased 1,900 175.0000 American 18 Apr 2019
ADR Call Options Purchased 2,000 150.0000 American 17 Jan 2020
ADR Call Options Purchased 2,100 190.0000 American 18 Apr 2019
ADR Call Options Purchased 2,200 170.0000 American 18 Jan 2019
ADR Call Options Purchased 2,600 185.0000 American 18 Apr 2019
ADR Call Options Purchased 3,100 155.0000 American 18 Jan 2019
ADR Call Options Purchased 3,800 125.0000 American 18 Jan 2019
ADR Call Options Purchased 4,300 170.0000 American 18 Apr 2019
ADR Call Options Purchased 5,700 160.0000 American 19 Jul 2019
ADR Call Options Purchased 6,000 193.0000 American 21 Dec 2018
ADR Call Options Purchased 7,200 173.0000 American 21 Dec 2018
ADR Call Options Purchased 7,700 155.0000 American 18 Apr 2019
ADR Call Options Purchased 8,500 185.0000 American 21 Dec 2018
ADR Call Options Purchased 9,200 200.0000 American 15 Jan 2021
ADR Call Options Purchased 11,200 175.0000 American 21 Dec 2018
ADR Call Options Purchased 18,200 160.0000 American 18 Jan 2019
ADR Call Options Purchased 20,300 190.0000 American 21 Dec 2018
ADR Call Options Purchased 22,300 200.0000 American 18 Jan 2019
ADR Call Options Purchased 23,900 195.0000 American 18 Jan 2019
ADR Call Options Purchased 138,200 190.0000 American 18 Jan 2019
ADR Call Options Written -56,000 200.0000 American 17 Jan 2020
ADR Call Options Written -42,400 200.0000 American 19 Jul 2019
ADR Call Options Written -34,300 180.0000 American 18 Jan 2019
ADR Call Options Written -33,600 185.0000 American 18 Jan 2019
ADR Call Options Written -22,500 190.0000 American 21 Dec 2018
ADR Call Options Written -11,700 165.0000 American 21 Dec 2018
ADR Call Options Written -11,500 185.0000 American 21 Dec 2018
ADR Call Options Written -5,000 178.0000 American 21 Dec 2018
ADR Call Options Written -3,800 170.0000 American 21 Dec 2018
ADR Call Options Written -2,700 145.0000 American 18 Jan 2019
ADR Call Options Written -2,400 130.0000 American 18 Jan 2019
ADR Call Options Written -1,500 210.0000 American 19 Jul 2019
ADR Call Options Written -1,000 210.0000 American 21 Dec 2018
ADR Call Options Written -1,000 85.0000 American 18 Jan 2019
ADR Call Options Written -800 155.0000 American 18 Apr 2019
ADR Call Options Written -600 160.0000 American 18 Jan 2019
ADR Call Options Written -500 160.0000 American 18 Apr 2019
ADR Call Options Written -500 135.0000 American 19 Jul 2019
ADR Call Options Written -500 173.0000 American 14 Dec 2018
ADR Call Options Written -100 150.0000 American 18 Apr 2019
ADR Call Options Written -100 140.0000 American 17 Jan 2020
ADR Put Options Purchased -277,200 165.0000 American 18 Jan 2019
ADR Put Options Purchased -157,900 165.0000 American 21 Dec 2018
ADR Put Options Purchased -43,900 135.0000 American 18 Jan 2019
ADR Put Options Purchased -23,600 170.0000 American 21 Dec 2018
ADR Put Options Purchased -15,200 160.0000 American 18 Apr 2019
ADR Put Options Purchased -7,300 170.0000 American 14 Dec 2018
ADR Put Options Purchased -5,900 180.0000 American 18 Jan 2019
ADR Put Options Purchased -5,300 165.0000 American 15 Jan 2021
ADR Put Options Purchased -4,600 155.0000 American 18 Jan 2019
ADR Put Options Purchased -3,700 145.0000 American 17 Jan 2020
ADR Put Options Purchased -3,700 145.0000 American 21 Dec 2018
ADR Put Options Purchased -3,500 140.0000 American 18 Jan 2019
ADR Put Options Purchased -2,700 80.0000 American 18 Jan 2019
ADR Put Options Purchased -2,500 160.0000 American 15 Jan 2021
ADR Put Options Purchased -2,500 120.0000 American 17 Jan 2020
ADR Put Options Purchased -2,300 85.0000 American 18 Jan 2019
ADR Put Options Purchased -2,000 130.0000 American 15 Jan 2021
ADR Put Options Purchased -2,000 80.0000 American 17 Jan 2020
ADR Put Options Purchased -1,800 115.0000 American 18 Jan 2019
ADR Put Options Purchased -1,700 160.0000 American 17 Jan 2020
ADR Put Options Purchased -1,400 165.0000 American 17 Jan 2020
ADR Put Options Purchased -1,200 135.0000 American 17 Jan 2020
ADR Put Options Purchased -1,100 70.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 155.0000 American 15 Jan 2021
ADR Put Options Purchased -1,000 170.0000 American 17 Jan 2020
ADR Put Options Purchased -800 150.0000 American 17 Jan 2020
ADR Put Options Purchased -500 140.0000 American 17 Jan 2020
ADR Put Options Purchased -400 170.0000 American 18 Jan 2019
ADR Put Options Purchased -400 165.0000 American 19 Jul 2019
ADR Put Options Purchased -200 65.0000 American 17 Jan 2020
ADR Put Options Purchased -100 195.0000 American 15 Jan 2021
ADR Put Options Purchased -100 148.0000 American 14 Dec 2018
ADR Put Options Purchased -100 168.0000 American 14 Dec 2018
ADR Put Options Purchased -100 75.0000 American 17 Jan 2020
ADR Put Options Written 100 110.0000 American 17 Jan 2020
ADR Put Options Written 100 95.0000 American 18 Jan 2019
ADR Put Options Written 100 110.0000 American 18 Jan 2019
ADR Put Options Written 200 200.0000 American 17 Jan 2020
ADR Put Options Written 200 100.0000 American 18 Jan 2019
ADR Put Options Written 300 168.0000 American 21 Dec 2018
ADR Put Options Written 500 173.0000 American 14 Dec 2018
ADR Put Options Written 900 175.0000 American 21 Dec 2018
ADR Put Options Written 1,000 140.0000 American 21 Dec 2018
ADR Put Options Written 1,000 147.0000 American 28 Dec 2018
ADR Put Options Written 1,000 90.0000 American 18 Jan 2019
ADR Put Options Written 1,000 150.0000 American 21 Dec 2018
ADR Put Options Written 1,200 150.0000 American 18 Apr 2019
ADR Put Options Written 1,800 185.0000 American 18 Jan 2019
ADR Put Options Written 2,300 130.0000 American 18 Jan 2019
ADR Put Options Written 2,900 150.0000 American 18 Jan 2019
ADR Put Options Written 4,000 165.0000 American 18 Apr 2019
ADR Put Options Written 5,300 120.0000 American 18 Jan 2019
ADR Put Options Written 6,900 170.0000 American 18 Apr 2019
ADR Put Options Written 10,500 155.0000 American 21 Dec 2018
ADR Put Options Written 11,000 160.0000 American 19 Jul 2019
ADR Put Options Written 14,800 155.0000 American 18 Apr 2019
ADR Put Options Written 15,200 165.0000 American 21 Dec 2018
ADR Put Options Written 20,300 165.0000 American 18 Jan 2019
ADR Put Options Written 26,600 125.0000 American 18 Jan 2019
ADR Put Options Written 27,500 160.0000 American 21 Dec 2018
ADR Put Options Written 46,400 160.0000 American 18 Jan 2019
ADR Put Options Written 157,900 145.0000 American 21 Dec 2018
ADR Put Options Written 278,300 145.0000 American 18 Jan 2019

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20181214005233/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Shire plc published this content on 14 December 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 14 December 2018 13:49:03 UTC