LONDON--(BUSINESS WIRE)--

FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1.KEY INFORMATION

(a) Full name of discloser: Millennium International Management LP
(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient. For a trust, the trustee(s), settlor and beneficiaries must be named.

(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

 Shire plc
(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:
(e) Date position held/dealing undertaken:

For an opening position disclosure, state the latest practicable date prior to the disclosure

 28th December 2018
(f) In addition to the company in 1(c) above, is the discloser making disclosures in respect of any other party to the offer?

If it is a cash offer or possible cash offer, state 'N/A'

Yes, Takeda Pharmaceutical Company Limited

2.POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a)Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary (JE00B2QKY057) - interest [partially] held via holding of ADRs and ADR Options (US82481R1068)
Interests Short positions
Number % Number %
(1) Relevant securities owned and/or controlled: 6,348,528 0.691% 0
(2) Cash-settled derivatives: 20,896,201 2.276% 0
(3) Stock-settled derivatives (including options) and agreements to purchase/sell: 730,000 0.080% 120,000 0.013%

TOTAL:

 27,974,729 3.047% 120,000 0.013%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b)Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3.DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a)Purchases and sales

Class of relevant security Purchase/sale Number of securities Price per unit (USD)
US82481R1068 Sale 9 172.54
US82481R1068 Sale 100 172.70
US82481R1068 Sale 200 172.87
US82481R1068 Sale 249 172.88
US82481R1068 Sale 200 172.89
US82481R1068 Sale 3,147 172.90
US82481R1068 Sale 3,003 172.91
US82481R1068 Sale 234 172.93
US82481R1068 Sale 225 172.94
US82481R1068 Sale 2,092 173.03
US82481R1068 Sale 88 173.10
US82481R1068 Sale 1,525 173.25
US82481R1068 Sale 215 173.36
US82481R1068 Sale 1,613 173.37
US82481R1068 Sale 200 172.51
US82481R1068 Sale 100 172.54
US82481R1068 Sale 100 172.60
US82481R1068 Sale 100 172.61
US82481R1068 Sale 200 172.64
US82481R1068 Sale 200 172.66
US82481R1068 Sale 100 172.67
US82481R1068 Sale 200 172.68
US82481R1068 Sale 100 172.69
US82481R1068 Sale 222 172.70
US82481R1068 Sale 100 172.71
US82481R1068 Sale 300 172.72
US82481R1068 Sale 500 172.73
US82481R1068 Sale 200 172.74
US82481R1068 Sale 400 172.75
US82481R1068 Sale 200 172.76
US82481R1068 Sale 500 172.77
US82481R1068 Sale 800 172.78
US82481R1068 Sale 600 172.79
US82481R1068 Sale 300 172.80
US82481R1068 Sale 300 172.81
US82481R1068 Sale 200 172.82
US82481R1068 Sale 800 172.83
US82481R1068 Sale 200 172.84
US82481R1068 Sale 400 172.85
US82481R1068 Sale 100 172.86
US82481R1068 Sale 200 172.87
US82481R1068 Sale 100 172.89
US82481R1068 Sale 500 172.90
US82481R1068 Sale 400 172.91
US82481R1068 Sale 100 172.92
US82481R1068 Sale 200 172.93
US82481R1068 Sale 500 172.94
US82481R1068 Sale 600 172.95
US82481R1068 Sale 800 172.96
US82481R1068 Sale 500 172.97
US82481R1068 Sale 200 172.98
US82481R1068 Sale 417 172.99
US82481R1068 Sale 2,213 173.00
US82481R1068 Sale 863 173.01
US82481R1068 Sale 300 173.02
US82481R1068 Sale 500 173.03
US82481R1068 Sale 300 173.04
US82481R1068 Sale 100 173.05
US82481R1068 Sale 500 173.06
US82481R1068 Sale 878 173.07
US82481R1068 Sale 200 173.08
US82481R1068 Sale 300 173.09
US82481R1068 Sale 500 173.10
US82481R1068 Sale 300 173.11
US82481R1068 Sale 200 173.12
US82481R1068 Sale 300 173.14
US82481R1068 Sale 400 173.17
US82481R1068 Sale 200 173.18
US82481R1068 Sale 77 173.19
US82481R1068 Sale 200 173.20
US82481R1068 Sale 300 173.21
US82481R1068 Sale 300 173.22
US82481R1068 Sale 100 173.23
US82481R1068 Sale 200 173.24
US82481R1068 Sale 300 173.25
US82481R1068 Sale 100 173.26
US82481R1068 Sale 300 173.27
US82481R1068 Sale 100 173.28
US82481R1068 Sale 300 173.29
US82481R1068 Sale 300 173.30
US82481R1068 Sale 100 173.31
US82481R1068 Sale 200 173.33
US82481R1068 Sale 100 173.34
US82481R1068 Sale 200 173.35
US82481R1068 Sale 200 173.37
US82481R1068 Sale 100 173.39
US82481R1068 Sale 200 173.41
US82481R1068 Sale 200 173.42
US82481R1068 Sale 100 173.43
US82481R1068 Sale 100 173.44
US82481R1068 Sale 100 173.46
US82481R1068 Sale 400 173.50
US82481R1068 Sale 100 173.55
US82481R1068 Sale 100 173.62
US82481R1068 Sale 100 173.64
US82481R1068 Sale 100 173.67
US82481R1068 Sale 100 173.68
US82481R1068 Sale 100 173.69
US82481R1068 Purchase 100 172.72
US82481R1068 Purchase 100 172.81
US82481R1068 Purchase 200 172.82
US82481R1068 Purchase 300 172.84
US82481R1068 Purchase 100 172.90
US82481R1068 Purchase 102 173.00
US82481R1068 Purchase 200 173.19
US82481R1068 Purchase 100 173.22
US82481R1068 Purchase 300 173.25
US82481R1068 Purchase 100 173.27
US82481R1068 Purchase 100 173.32
US82481R1068 Purchase 200 173.40
US82481R1068 Purchase 100 173.49
US82481R1068 Purchase 100 173.56
US82481R1068 Sale 2 172.74
US82481R1068 Sale 1,500 172.92
US82481R1068 Sale 400 172.93
US82481R1068 Sale 100 172.96
US82481R1068 Sale 200 172.99
US82481R1068 Sale 1,320 173.00
US82481R1068 Sale 598 173.02
US82481R1068 Sale 500 173.03
US82481R1068 Sale 200 173.05
US82481R1068 Sale 100 173.06
US82481R1068 Sale 100 173.07
US82481R1068 Sale 112 173.08
US82481R1068 Sale 100 173.12
US82481R1068 Sale 100 173.13
US82481R1068 Sale 200 173.15
US82481R1068 Sale 6 173.94

(b)Cash-settled derivative transactions

Class of relevant security Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities Price per unit
(GBP)
JE00B2QKY057 CFD Increasing a long position 822 45.58
Class of relevant security Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities Price per unit
(USD)
US82481R1068 CFD Increasing a long position 647 173.29

(c)Stock-settled derivative transactions (including options)

(i)Writing, selling, purchasing or varying

Class of relevant security Product description e.g. call option Writing, purchasing, selling, varying etc. Number of securities to which option relates Exercise price per unit Type

e.g. American, European etc.

Expiry date Option money paid/ received per unit

(ii)Exercise

Class of relevant security Product description

e.g. call option

Exercising/ exercised against Number of securities Exercise price per unit

(d)Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

4.OTHER INFORMATION

(a)Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

NONE

(b)Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

NONE

(c)Attachments

Is a Supplemental Form 8 (Open Positions) attached? YES
Date of disclosure: 31st December 2018
Contact name: Myriam Soper
Telephone number: +44 203 650 8261

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk.The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1.KEY INFORMATION

Full name of person making disclosure: Millennium International Management LP
Name of offeror/offeree in relation to whose relevant securities the disclosure relates: Shire plc

2.STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class of relevant security Product description e.g. call option Written or purchased Number of securities to which option or derivative relates Exercise price per unit Type

e.g. American, European etc.

Expiry date
US82481R1068 Call Option Purchased 360,000 180

USD

American 18.1.2019
US82481R1068 Call Option Purchased 120,000 4,400
GBP 		American 15.3.2019
US82481R1068 Put Option Purchased 120,000 4,800
GBP 		American 15.3.2019
US82481R1068 Call Option Purchased 250,000 5,200
GBP 		American 18.1.2018

3.AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20190101005011/en/

Millennium Partners, L.P.

Source: Millennium Partners, L.P.

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Shire plc published this content on 02 January 2019 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 02 January 2019 07:13:03 UTC