Data on Neuroscience Discussed by Researchers at Nankai University (Rapamycin relieves anxious emotion and synaptic plasticity deficits induced by hindlimb unloading in mice)
By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Nervous System Research - Neuroscience have been published. According to news reporting originating in Tianjin, People's Republic of China, by NewsRx journalists, research stated, "This study examined whether increasing autophagy could improve cognitive deficits in hindlimb unloaded (HU) mice, which was used as an animal model of synaptic plasticity impairment. Male C57BL/6 mice were randomly divided into three groups: control, HU and HU + rapamycin groups."
Financial support for this research came from National Natural Science Foundation of China (see also Nervous System Research - Neuroscience).
The news reporters obtained a quote from the research from Nankai University, "Hindlimb unloading treatment was used to establish the animal model for 2 weeks. Rapamycin was intraperitoneally injected at a dose of 0.5 mg/kg/day along with hindlimb unloading procedure. The open field test and the elevated plus maze test showed that rapamycin considerably prevented the level of anxiety and increased exploratory behaviour in HU mice. Afterwards, long-term potentiation (LTP) recorded in the hippocampal dentate gyrus (DG) region was effectively reduced by rapamycin, which was significantly inhibited by HU procedure. In addition, rapamycin further increased the autophagy level, which was already elevated in HU mice. Meanwhile, the expression of NMDA receptor 2A and 2 B was modified by rapamycin in HU mice. Moreover, rapamycin noticeably increased the total superoxide dismutase (T-SOD) activity and reduced the malondialdehyde (MDA) as well as the level of carbonylated proteins in HU mice's hippocampus."
According to the news reporters, the research concluded: "The results show that increasing autophagy may pacificate the anxious emotion, and partly alleviate the hippocampal synaptic plasticity deficits."
For more information on this research see: Rapamycin relieves anxious emotion and synaptic plasticity deficits induced by hindlimb unloading in mice. Neuroscience Letters, 2018;677():44-48. Neuroscience Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Neuroscience Letters - www.journals.elsevier.com/neuroscience-letters/)
Our news correspondents report that additional information may be obtained by contacting T. Zhang, Nankai Univ, Minist Educ, Coll Life Sci, Tianjin 300071, People's Republic of China. Additional authors for this research include X.L. Shang, J.X. Fu, F.J. Li and B.H. Zhai.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.neulet.2018.04.033. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Tianjin, People's Republic of China, Asia, Neuroscience, Nervous System Research, Nankai University.
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