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MarketScreener Homepage  >  Equities  >  NATIONAL STOCK EXCHANGE OF INDIA  >  UPL    UNITEDPHOS   INE628A01036

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Patent Issued for Method For Controlling Rust (USPTO 10,362,782): UPL Limited

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08/14/2019 | 05:05pm EDT

2019 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at Chemicals & Chemistry Business Daily Business Daily Daily -- According to news reporting originating from Alexandria, Virginia, by NewsRx journalists, a patent by the inventors Oliveira, Gilson Aparecido Hermenegildo de (Sao Paulo, BR); Shroff, Jaidev Rajnikant (Maharashtra, IN); Shroff, Vikram Rajnikant (Maharashtra, IN), filed on August 9, 2017, was published online on August 12, 2019.

The assignee for this patent, patent number 10,362,782, is UPL Limited (Haldia, West Bengal, India).

Reporters obtained the following quote from the background information supplied by the inventors: “The fungus of the genus Phakopsora is known to infect legumes. Two most prominent strains of the genus are Phakopsora pachyrhizi and Phakopsora meibomiae. Soybean rust caused by Phakopsora pachyrhizi is the most damaging disease affecting the yield of leguminous plants causing widespread damage to crops and depleting yield from 10 to 90% if not treated in time. Commonly known as Asian Soybean Rust (ASR), Phakopsora pachyrhizi infections must be detected early and treated early so as to prevent the geographic spread of the disease, which is airborne and causes severe loss of yield. The disease spreads through spores called urediniospores which are carried through the environs, resulting in wide spread damage. The disease earlier restricted to Asia and Australia has spread to Africa and in the past two decades, spread to South and North America. The first detection in the Americas was in 2001 in South America; from there it spread to North America where it was first detected in 2004.

“Phakopsora pachyrhizi is known to infect over 30 legumes including commercially important edible beans as well as kudzu. The additional host crops serve as a reservoir for spores which can settle over the winter on the host crops and then spread in warmer weather. Early detection and treatment of Phakopsora is very essential to prevent the spread of disease and the loss of yield. Fungicides typically recommended for the treatment of this disease include Qo inhibitors (Quinone outside inhibitors), DM inhibitors (demethylation inhibitor), SDH Inhibitors (succinate dehydrogenase inhibitors). These fungicides when applied alone provided some control but, resistance was quickly observed, specifically in DM inhibitors (K Schmitz e al, Pest Management Science, Vol. 69, Issue 10 (2013)). Combination of Qo and DM inhibitors are also known in the art for the treatment of the disease, however, the treatment is not effective in controlling the disease and improving yields at the same time. Also, resistance to DM inhibitors effectively renders such combination compositions useless as the ASR strains can effectively overcome the effects of DM inhibitors. Venancio et. al (Poster #24, 2011 Field Crops Rust Symposium) taught the use of combination of stroilurins (Qo inhibitors) and triazoles (DM inhibitors) for the treatment of ASR, the control of the disease was found to be favorable; however, yield was significantly low, and some combinations showed lower disease control and significantly poor yield. Older studies have demonstrated the use of multi-site inhibitor fungicides such as chloronitriles and dithiocarbamate for the treatment of Soybean Rust; however, none of the multi-site inhibitor fungicides were successful in the control of the disease or the increase in yield.

“The most important factor in Soybean Rust is the loss of foliage that results in the loss of nutrients and decrease in the overall yield of the crop. Numerous papers have been published that demonstrate moderate increase in yield with the application of fungicides. However, there is a need for a method of treatment that demonstrates improved yields along with preventive and/or curative capabilities in the treatment of Soybean Rust.

“Compositions comprising the single actives used in the treatment of ASR have demonstrated very little control as compared to combinations, however, the cost and concentrations of such combination fungicides used in the treatment of ASR is significantly higher. There is therefore a need in the art for a method of treatment that provides excellent control over Asian Soybean Rust in host plants, as well as provides high yields, maintain nutrition and quality of the plants.

“Hartman, G. L., Saadaoui, E. M, and Tschanz, A. T., Scientific eds. 1992, Annotated bibliography of soybean rust (Phakopsora pachyrhizi Sydow), A VRDC Library Bibliography Series 4-1, Tropical Vegetable Information Service. Taipei: Asian Vegetable Research and Development Center, recommended the use of triadimefon, thiabendazole, chlorothalonil and certain ethylenebis-dithiocarbamates for the control of soybean rust. The protection offered by triadimefon was inconsistent, in comparison to mancozeb, although it successfully prevented yield losses. However, triadimefon required frequent applications at 10-20 day intervals, starting from the flowering stage in order to retain its effectiveness. Thiabendazole was found to be less effective than certain ethylenebis-dithiocarbamates, and further was found effective only when used with oxycarboxin. Thiabendazole was also found to be phytotoxic. Chlorothalonii offered equal or worse rust control vis-a-vis the other fungicides recommended in this paper.

“The use of ethylenebis-dithiocarbamates such as mancozeb, zineb or maneb alone has been found effective for the control of soybean rust when applied 7 to 21 days apart, provided the first application was made three weeks after planting and continued as late as till the flowering stage. Moreover, not all the studied showed yield increase due to the individual applications of ethylenebis-dithiocarbamates.

“Oxycarboxin was found less effective than ethylenebis-dithiocarbamates, was found inconsistent in rust control and yield protection varied with the particular study. Oxycarboxin is also required to be applied when lesions first appear and then at 7-intervals for effective control, which is expensive and inconvenient.

“Azoxystrobin is another fungicide, which has been recommended for soybean rust control. However, it is known in the art that a single late application of azoxystrobin does not control soybean rust or protect yield losses.

“A recent survey by the present applicant found that a limited number of about 8-10 fungicides were approved to be used for the control of soybean rust, which are: (A) Conazole type fungicides such as myclobutanil, propiconazole, tetraconazole and tebuconazole; (B) Strobilurin type fungicides such as azoxystrobin and pyraclostrobin; (C) Combinations of conazole and strobilurin type fungicides such as propiconazole+trilfoxystrobin; and (D) Ethylenebis-dithiocarbamates such as mancozeb.

“Thus, additional fungicides are needed for soybean rust control due to economic reasons as well as for resistance management strategies. However, the choice of fungicides for soybean is not straightforward.

“Soybean is not usually treated with foliar fungicides. Therefore, the choice of a protective foliar fungicide leaves open the question of its application methods or the effect of the particular selected fungicide on the crop. The pathogen for soybean rust is usually found on the lower leaves of the plant where the lesion numbers increases as the inoculum builds up. As the plant begins to flower, this inoculum builds up increases and the infection moves up the plant as the lower leaves die off and drop. The crop needs protection from flowering stage to the pod fill stage, during which the plant canopy is very dense. The dense canopy is an effective barrier to penetration of fungicides applied over the top of the canopy. Therefore, foliar fungicides are not preferred during this stage of fungicidal control, or even the systemic fungicides that do not move down the plant system present a problem.

“U.S. Pat. No. 8,044,084 discloses a method for controlling harmful fungi by applying a combination of a strobilurin fungicide with an ethylene modulator. It was found that the host plants are damaged to a lesser extent than after the treatment with a customary fungicide. Specifically, this patent teaches a combination of pyraciostrobin with prohexadione-Ca in weight ratio of from 20:1 to 0.05:1.

“US 2011/0312493 teaches a method for controlling Asian soybean rust. The method comprises treating a glyphosate tolerant soybean plant propagation material with a fungicide selected from fiutriafoi, triticonazole, tebuconazole, ipconazole, epoxyconazole, orysastrobin, prothioconazole, fiuoxastrohin, azoxyscrobin, furametpyr, cyproconazole and subsequently with glyphosate.

“US 2008/0153824 discloses for controlling rust infections in leguminous plants by using orysastrobin or a mixture of orysastrobin with azoles, acylaianines, amine derivatives, anilinopyximidines, dicarboximides, dithiocarbmates, heterocyclic compounds, phenylpyrroles, cinnamides and analogs thereof.

“WO 2012/110464 discloses a method for controlling Asian soybean rust by applying a succinate dehydrogenase inhibitor fungicide.

“There is a need in the art for a fungicidal method of control of soybean rust that takes into account the economics of fungicide application, the timing and number of sprays and lastly, the choice of the fungicide for an effective control. These issues present a considerable challenge to an agronomist.

“Moreover, the single fungicide treatment regimen for Asian Soybean Rust (ASR) has many drawbacks. Azoxystrobin was one of the first of the Qo inhibitors to be used for the treatment of soybean rust individually and it provided good control. However, according to FRAC guidelines, Azoxystrobin should be used more as a preventive fungicide rather than a curative fungicide. The risk of resistance to Qo inhibitors is also very high. Another drawback is that even at the lowest labeled rate of use product, Qo inhibitor fungicide still costs the highest.

“Alternatively, DM Inhibitors have shown good efficacy towards ASR, however, recent findings have suggested that Phakopsora pachyrhizi is capable of developing resistance to DM inhibitors.

“Combinations of Qo inhibitors and DM inhibitors are currently registered in the Americas have demonstrated 40 to 60% control of ASR. However, the control efficacy mixtures of DM inhibitors with Qo inhibitors have reduced in the past seasons. Also, there is no great increase in yield and no decrease in the stress on the plant due to pest pressure.

“Use of SDH inhibitors is also recommended for soybean rust control. However, single fungicides such as Boscalid offer only a moderate control of ASR.

“Dithiocarbamates, and mancozeb in particular, was one of the first fungicides to be used for the treatment of ASR. Over the years many trials have been conducted on the use of Mancozeb alone for the treatment of ASR. However, the efficacy of mancozeb alone towards soybean rust control requires further research.

“The present invention aims to overcome the problems in the prior art, namely, the need for a method of treatment that will not render Phakopsora resistant to actives, improve yield substantially and at reduced concentrations of actives, as well as reduced costs.”

In addition to obtaining background information on this patent, NewsRx editors also obtained the inventors’ summary information for this patent: “In an aspect, the present invention provides an improved method of treating soybean rust infection in a host leguminous plant, wherein the improvement comprises treating the plant at the locus of the infection with a dithiocarbamate fungicide, and concurrently, prior or subsequently to the dithiocarbamate fungicide, with at least another fungicide selected from a demethylation inhibitor, quinone outside inhibitor, succinate dehydrogenase inhibitor, quinone inside inhibitor or combinations thereof.

“In another aspect, the present invention provides a fungicidal combination for treating soybean rust infection in a host leguminous plant, wherein the combination comprises a first dithiocarbamate fungicide, and at least second fungicide selected from a demethylation inhibitor, quinone outside inhibitor, succinate dehydrogenase inhibitor, quinone inside inhibitor or combinations thereof.

“In another aspect, the present invention provides the use of a dithiocarbamate fungicide as a synergist to improve disease control in a host plant infected by soybean rust when applied subsequently, prior or concurrently to at least another fungicide selected from a demethylation inhibitor, quinone outside inhibitor, succinate dehydrogenase inhibitor, quinone inside inhibitor or combinations thereof.”

The claims supplied by the inventors are:

“The invention claimed is:

“1. A fungicidal combination, consisting of: (i) mancozeb, (ii) prothioconazole, and (a) at least one succinate dehydrogenase inhibitor fungicide selected from the group consisting of benodanil, flutolanil, mepronil, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, and boscalid; or (b) at least one quinone outside inhibitor fungicides selected from the group consisting of fenamidone, famoxadone, and a strobilurin fungicide selected from the group consisting of azoxystrobin, mandestrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, pyraoxystrobin, dimoxystrobin, enestrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyrametostrobin, triclopyricarb, fenaminstrobin, pyraclostrobin and trifloxystrobin; or © at least one demethylation inhibitor fungicide selected from the group consisting of triflumizole, triforine, pyridinitrile, pyrifenox, fenarimol, nuarimol, triarimol, and a conazole fungicide selected from the group consisting of climbazole, clotrimazole, imazalil, oxpoconazole, prochloraz, prochloraz-manganese, triflumizole, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluotrimazole, fluquinconazole, flusilazole, flutriafol, furconazole, imibenconazole, ipconazole, furconazole-cis, metconazole, hexaconazole, myclobutanil, pencoconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, perfurazoate, and uniconazole-P; and (iii) at least one agriculturally acceptable excipient.

“2. The fungicidal combination according to claim 1, wherein (i) the strobilurin fungicide is selected from the group consisting of trifloxystrobin, picoxystrobin, azoxystrobin, and pyraclostrobin; and (ii) the conazole fungicide is selected from cyproconazole, epoxiconazole, metconazole, and tebuconazole.

“3. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, at least one succinate dehydrogenase inhibitor fungicide, and at least one agriculturally acceptable excipient.

“4. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, bixafen, and at least one agriculturally acceptable excipient.

“5. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, isopyrazam, and at least one agriculturally acceptable excipient.

“6. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole boscalid, and at least one agriculturally acceptable excipient.

“7. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, azoxystrobin, and at least one agriculturally acceptable excipient.

“8. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, picoxystrobin, and at least one agriculturally acceptable excipient.

“9. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, pyraclostrobin, and at least one agriculturally acceptable excipient.

“10. The fungicidal combination according to claim 1, wherein the combination consists of mancozeb, prothioconazole, trifloxystrobin, and at least one agriculturally acceptable excipient.

“11. A method of treating soybean rust in a host leguminous plant, comprising: applying to the plant at the locus of the infection a fungicidal combination according to claim 1.

“12. A kit comprising a fungicidal combination consisting of: (i) mancozeb, (ii) prothioconazole, and (a) at least one succinate dehydrogenase inhibitor fungicide selected from the group consisting of benodanil, flutolanil, mepronil, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, and boscalid; or (b) at least one quinone outside inhibitor fungicides selected from the group consisting of fenamidone, famoxadone, and a strobilurin fungicide selected from the group consisting of azoxystrobin, mandestrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, pyraoxystrobin, dimoxystrobin, enestrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyrametostrobin, triclopyricarb, fenaminstrobin, pyraclostrobin and trifloxystrobin; or © at least one demethylation inhibitor fungicide selected from the group consisting of triflumizole, triforine, pyridinitrile, pyrifenox, fenarimol, nuarimol, triarimol, and a conazole fungicide selected from the group consisting of climbazole, clotrimazole, imazalil, oxpoconazole, prochloraz, prochloraz-manganese, triflumizole, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluotrimazole, fluquinconazole, flusilazole, flutriafol, furconazole, imibenconazole, ipconazole, furconazole-cis, metconazole, hexaconazole, myclobutanil, pencoconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, perfurazoate, and uniconazole-P; and (iii) at least one agriculturally acceptable excipient.”

For more information, see this patent: Oliveira, Gilson Aparecido Hermenegildo de; Shroff, Jaidev Rajnikant; Shroff, Vikram Rajnikant. Method For Controlling Rust. U.S. Patent Number 10,362,782, filed August 9, 2017, and published online on August 12, 2019. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=10,362,782.PN.&OS=PN/10,362,782RS=PN/10,362,782

(Our reports deliver fact-based news of research and discoveries from around the world.)

Copyright © 2019 NewsRx LLC, Chemicals & Chemistry Business Daily, source Science Newsletters

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