Item 5.07 Submission of Matters to a Vote of Security Holders.

The Vertex Pharmaceuticals Incorporated (the "Company") 2020 annual meeting of shareholders was held on June 3, 2020. The final voting results were as follows:

1. Based upon the following votes, the shareholders elected Sangeeta Bhatia,

Lloyd Carney, Alan Garber, Terrence Kearney, Reshma Kewalramani, Yuchun Lee,
   Jeffrey Leiden, Margaret McGlynn, Diana McKenzie and Bruce Sachs to serve as
   members of the Company's board of directors until the annual meeting of
   shareholders to be held in 2021:


                       For      Against   Abstain Non-Votes

Sangeeta Bhatia 227,477,836 421,281 77,317 8,792,258 Lloyd Carney 213,657,277 14,237,178 81,979 8,792,258 Alan Garber 226,552,476 1,344,140 79,818 8,792,258 Terrence Kearney 225,194,201 2,700,223 82,010 8,792,258 Reshma Kewalramani 227,155,435 746,821 74,178 8,792,258 Yuchun Lee 225,827,265 2,069,029 80,140 8,792,258 Jeffrey Leiden 224,042,702 3,844,535 89,197 8,792,258 Margaret McGlynn 227,432,472 467,171 76,791 8,792,258 Diana McKenzie 227,475,847 423,588 76,999 8,792,258 Bruce Sachs 217,205,841 10,689,749 80,844 8,792,258

2. Based upon the following votes, the shareholders ratified the appointment of

Ernst & Young LLP as the Company's independent registered public accounting
   firm for the year ending December 31, 2020:



    For      Against  Abstain Non-Votes
231,416,102 5,262,659 89,931      0



3. Based upon the following votes, the shareholders approved, on an advisory


   basis, the 2019 compensation program for the Company's named executive
   officers:



    For      Against   Abstain Non-Votes
215,703,365 12,174,126 98,943  8,792,258



4. Based upon the following votes, the shareholders did not approve a shareholder


   proposal requesting a report on the Company's policies and activities with
   respect to lobbying:



    For       Against    Abstain  Non-Votes
106,762,421 112,776,139 8,437,874 8,792,258

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