Log in
E-mail
Password
Remember
Forgot password ?
Become a member for free
Sign up
Sign up
Settings
Settings
Dynamic quotes 
OFFON

MarketScreener Homepage  >  News  >  Companies  >  All News

News : Companies
Latest NewsCompaniesMarketsEconomy & ForexCommoditiesInterest RatesBusiness LeadersFinance ProfessionalsCalendarSectors

Study Shows First Practical Intervention For Chemobrain

share with twitter share with LinkedIn share with facebook
share via e-mail
0
10/31/2016 | 03:01pm EDT

SAN FRANCISCO, Oct. 31, 2016 (GLOBE NEWSWIRE) -- For the first time, symptoms of cancer-related cognitive decline – often called “chemobrain” –  were reversed in a large, home-based, randomized controlled trial, using unique computerized brain exercises, according to a report today in the Journal of Clinical Oncology.

Breast cancer support groups first brought attention to a phenomenon they called “chemobrain” or “chemofog” in the 1980s, and its seriousness and very existence were questioned by many in the medical profession. Studies on the condition did not begin until the late 1990s, and there continues to be controversy over its causes.

Despite studies indicating that up to 70 percent of patients treated with chemotherapy experience cognitive decline; that such symptoms can persist for 10 or more years; and that the effects can interfere with maintaining employment, relationships and day-to-day independence; there are no broadly accepted treatments for cancer-related cognitive impairment. Millions of patients are treated with chemotherapy each year, and there are more than 35 million people with 5 or more years of cancer survival, worldwide.

Researchers from the Survivorship Research Group, University of Sydney, Australia conducted a randomized controlled trial among 242 cancer survivors, who reported cognitive problems 6-60 months after completing chemotherapy.

All study participants received a phone consultation. Half were assigned to the control group and received standard care from their healthcare providers, and the other half received standard care plus were asked to engage in a home-based intervention of online brain exercises for a total of 40 hours (40 minutes, 4 times per week, for 15 weeks). The exercises used in the study were a suite of five visual speed of processing exercises that are part of BrainHQ, a commercially-available, online, brain-training subscription service. 

Researchers administered this home-based study remotely, using a standard self-report cognitive assessment (FACT-COG), with the Perceived Cognitive Impairment (PCI) subscale designated as the primary outcome measure.  Secondary endpoints included standard self-report assessments of stress (PSS); fatigue (FACT-F); anxiety/depression (GHQ); quality of life (QOL FACT-G); and an online self-administered neuropsychological test (Cogstate). Participants were assessed at baseline, after the 15-week intervention, and six months later.

Researchers reported that the intervention group, as compared to the control group, reported significantly better Perceived Cognitive Impairment (the primary outcome measure: FACT-COG PCI) immediately after the intervention (p<0.0001), and six months later (p<0.0002). 

The intervention group also had significantly better performance on many secondary measures, including: on the stress measure after intervention and at six months; fatigue and anxiety/depression measures after training and with a trend to better performance at six months; on the quality of life measure at six months, but not immediately after training; and on all FACT-COG subscales after intervention, but only on some at six months. The computerized neuropsychological assessment (Cogstate) showed no between group difference after training or six months later.

“The use of this web-based intervention led to improvements in cognitive symptoms that were sustained six months later,” said Dr. Janette Vardy of the University of Sydney, the senior author on the paper. “While this builds on prior work, to our knowledge, it is the largest trial showing improvement in cognitive symptoms among cancer survivors after chemotherapy.”

“This is an important step forward,” commented Dr. Diane Von Ah of Indiana University, who ran a prior study using the same intervention, with similar results, in a classroom setting. “This new study suggests that this program can be used successfully in the home to address a serious problem that has too often been ignored, trivialized, or even denied to exist.”

“We are excited by the addition of these independent research results to our body of knowledge,” said Dr. Henry Mahncke, CEO of Posit Science, the maker of the BrainHQ exercises used in this intervention. “We plan to approach appropriate regulatory agencies to explore the shortest path to getting a form of these exercises into the hands of patients who may be helped.”

For additional information, contact:
Jeff Zimman
jeff.zimman@positscience.com

Primary Logo


© GlobeNewswire 2016
share with twitter share with LinkedIn share with facebook
share via e-mail
0
Latest news "Companies"
08:09pBRAGAR EAGEL & SQUIRE, P.C. ANNOUNCES THAT A CLASS ACTION LAWSUIT HAS BEEN FILED AGAINST FARFETCH LIMITED (NYSE : FTCH) and Encourages Farfetch Investors to Contact the Firm
BU
08:07pCOSCO SHIPPING PORTS : (1) discloseable transaction - disposal of interest in various port assets and (2) possible disposal of taicang terminal and jiangsu petrochemical terminal
PU
08:07pDEADLINE ALERT : Bragar Eagel & Squire, P.C. Reminds Investors That a Class Action Lawsuit Has Been Filed Against Oasmia Pharmaceutical AB (NASDAQ: OASM) and Encourages Oasmia Investors to Contact the Firm
PR
08:02pBragar Eagel & Squire, P.C. Reminds Investors That Class Action Lawsuits Have Been Filed Against Sarepta Therapeutics, Canada Goose, and Meredith Corporation and Encourages Investors to Contact the Firm
GL
08:01pKirby McInerney LLP Continues Investigation of Shareholder Claims Against The RealReal, Inc.
BU
07:57pPALADIN ENERGY : Appendix 3B - Placement
PU
07:57pFAR EAST CONSORTIUM INTERNATIONAL : Discloseable transaction formation of joint ventures for acquisition of hotel in singapore
PU
07:57pPW MEDTECH : Major transaction and inside information disposal of cbpo shares, entering into the consortium agreement and submission of the preliminary non-binding privatization proposal
PU
07:57pTrilogy International Partners Inc. Sets Date to Report Third Quarter 2019 Results
GL
07:53pBragar Eagel & Squire, P.C. Reminds Investors That Class Action Lawsuits Have Been Filed Against Curaleaf, 2U, Granite Construction, and Pluralsight and Encourages Investors to Contact the Firm
GL
Latest news "Companies"