Certain Series A Preferred Stock of Spyre Therapeutics, Inc. are subject to a Lock-Up Agreement Ending on 13-DEC-2025. These Series A Preferred Stock will be under lockup for 61 days starting from 13-OCT-2025 to 13-DEC-2025.

Details:
Executive officers and directors have agreed, subject to specified exceptions, not to directly or indirectly this restriction terminates after the close of trading of the common stock on and including the 60th day after the date of this prospectus.