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International stocks trading in New York closed lower Wednesday as the S&P/BNY Mellon index of American depositary receipts fell 0.2% to 158.04.

The European index declined 0.6% to 153.51. The Asian index rose 0.4% to 181.31. The Latin American index declined 0.5% to 209.66, while the emerging-markets index added 0.1% to 295.50.

RedHill Biopharma Ltd., based in Israel, posted the largest decline, cratering 22.6% to $1.30, followed by shares of Peru's Aenza S.A.A., which tumbled 13.8% to $1.86. Shares of China-based 111 Inc. plunged 13.1% to $1.52.

China's Leju Holdings Ltd. was the biggest leader during the session, soaring 51.6% to $2.03. Hong Kong-based Lion Group Holding Ltd. rocketed 28.3% to $1.27. Quhuo Ltd., which is based in China, rounded out the top three leaders on Wednesday, with shares surging 17.2% to $1.70.

Data source: Dow Jones Market Data, FactSet.

(END) Dow Jones Newswires

12-06-23 1726ET