By Micah Maidenberg 



    The S&P/BNY Mellon index of American depositary receipts fell 0.6% Tuesday to 133.48. The European index closed at 111.23, 0.5% lower. The emerging-markets and the Asian indices dropped 0.3% and 0.5%, respectively, closing at 340.98 and 195.99. The index for Latin American ADRs was down 1.6% to 135.84 for the day. 


  The ADRs for pharmaceutical company AstraZeneca PLC rose 0.7% to $55.11. Earlier Tuesday, analysts at Berenberg said profitability at the drug maker should improve as its sales drivers in the near term require relatively little additional investment. Berenberg rates the British company a buy and points to the company's strong pipeline of drugs. 


  Chinese online-retailer JD.com Inc.'s ADRs fell 1.2% to $75.16. The company's JD Health International Inc. unit filed to go public in Hong Kong, a transaction that could raise at least $3 billion. The company operates China's largest online retail pharmacy by revenue and provides other health-related services. The offering for JD Health could be launched by December, people familiar with the matter told The Wall Street Journal. 


  Write to Micah Maidenberg at micah.maidenberg@wsj.com