While officials have an "eye" on risks around the world, including the surge in coronavirus infections from the Omicron variant, Powell said policymakers expect any headwinds to be short-lived and for the economy to hold up well.

Powell also said Fed officials will discuss plans for reducing the central bank's nearly $9 trillion balance sheet at their next two meetings, adding he expects there to be a "substantial" amount of shrinkage in the Fed's bond holdings.