"We may have a few quarters of negative growth, but again, that's not what I'm estimating, what I'm forecasting right now," Harker said in a virtual event with the Mid-Size Bank Coalition of America, adding the economy can withstand a "measured" and "methodical" tightening of financial conditions that would bring down demand. "We don't want to overdo it, but we have to act."

(Writing by Ann Saphir; Editing by Chris Reese)