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PRESS RELEASE: Marinomed Biotech AG announces positive data demonstrating Carragelose efficacy against SARS-CoV-2 variants

04/21/2021 | 01:46am EDT
DGAP-News: Marinomed Biotech AG / Key word(s): Study 
Marinomed Biotech AG announces positive data demonstrating Carragelose efficacy against SARS-CoV-2 variants 
2021-04-21 / 07:45 
The issuer is solely responsible for the content of this announcement. 
=---------------------------------------------------------------------------------------------------------------------- 
Marinomed Biotech AG announces positive data demonstrating Carragelose efficacy against SARS-CoV-2 variants 
  . Carragelose inactivates common SARS-CoV-2 variants with similar efficacy as wildtype virus in vitro 
  . Efficacy against wildtype SARS-CoV-2 is clinically proven^[1] 
  . COVID-19 pandemic currently mostly driven by three SARS-CoV-2 variants, B.1.1.7, B.135.1 and P1 (also known as 
    British, South-African, and Brazilian variant, respectively) 
  . Nasal and throat sprays as well as lozenges containing Carragelose already on the market 
Korneuburg, Austria, 21 April 2021 - Marinomed Biotech AG (VSE:MARI), an Austrian science-based biotech company with 
globally marketed therapeutics derived from innovative proprietary technology platforms, announced today that 
Carragelose inactivates the new, rapidly spreading variants and SARS-CoV-2 wildtype with similar efficacy in vitro. The 
Company tested the three variants that currently mostly drive the COVID-19 pandemic, namely the so-called British or 
B.1.1.7, the South-African or B.1.351, and the Brazilian or P1 variant.[*] The data demonstrate that also with 
increasing prevalence of virus variants, the marketed OTC Carragelose-based lozenges, nasal and throat sprays will 
continue to effectively contribute to combatting the COVID-19 pandemic. 
"The COVID-19 pandemic continues to be a major health, social, and economic burden, and we now see variants of 
SARS-CoV-2 taking over the dynamics of the pandemic. We are very confident in these results that show Carragelose 
inactivates SARS-CoV-2, independent of the mutations we tested," said Dr. Eva Prieschl-Grassauer, Chief Scientific 
Officer at Marinomed. "Given the broad antiviral efficacy and the physical mode of action, we were convinced that 
SARS-CoV-2 variants are unlikely to evade the antiviral efficacy of Carragelose. With these new results we confirmed 
the hypothesis that our Carragelose-based products continue to be effective also against the mutations of concern 
currently emerging strongly. We believe that this will hold true for any future variants." 
In recent in vitro tests, Marinomed included four lentiviruses differently pseudotyped with the spike protein of 
wild-type SARS-CoV-2 or one of the three variants B.1.1.7, B1.351 and P1, respectively. Carragelose was able to 
inactivate all four virus forms at concentrations below 5 µg/ml. This is clinically relevant for the use of 
Carragelose-containing products: The marketed nasal sprays have a Carragelose concentration of 1.2 mg / ml, a more than 
200-fold higher dose as shown to be effective in vitro. The non-sulfated polymers HPMC and CMC were ineffective even at 
the highest concentrations tested. 
In addition, two of the three SARS-CoV-2 variants (B1.1.7 and B1.351) were independently tested in Vero cell tissue 
culture in cooperation with the virological institute of the University Hospital Erlangen, Germany. Carragelose showed 
similar effectiveness against the SARS-CoV-2 wild type and the tested variants. 
Dr. Prieschl-Grassauer continued: "We are very pleased to show that Carragelose is effective regardless of the actual 
SARS-CoV-2 variant. With the extensive discussions we are seeing around maintaining efficacy against a mutating virus, 
it is reassuring to know that Carragelose is a simple, safe, and effective means of supporting the prevention and 
treatment of COVID-19. With the data we have already seen against SARS-CoV-2 wild type, we are confident that this will 
hold true also for SARS-CoV-2 variants in the clinic." 
Marinomed's lentivirus data show the ability of Carragelose to prevent the virus from attaching to the host cell. The 
infectious virus particles used in the cooperation with the virological institute of the University Hospital Erlangen 
mimic the effect of an actual infection, where the virus replicates in the host cells and then reinfects further cells, 
thereby spreading the infection in the body. Both are established and scientifically widely accepted models. Taken 
together, the data show how Carragelose can effectively inhibit SARS-CoV-2 variants in tissue culture. The cooperation 
partners plan to publish the data in a peer reviewed journal. 
About Carragelose(R): 
Carragelose(R) is a sulfated polymer from red seaweed and is a unique, broadly active anti-viral compound. It is known 
as a gentle yet effective and safe prevention and treatment against respiratory infections. Several clinical and 
preclinical studies have shown that Carragelose(R) forms a layer on the mucosa wrapping entering viruses, thereby 
inactivating them, and preventing them from infecting cells. Increasing clinical evidence indicates that Carragelose(R) 
can also inactivate SARS-CoV-2.^[1],[2] Marinomed is holder of the IP rights and has licensed Carragelose(R) for 
marketing in Europe, parts of Asia, Canada, and Australia. For a full list of Marinomed's portfolio of Carragelose(R) 
containing nasal sprays and oral products, please visit https://www.carragelose.com/en/portfolio/launched-products, for 
a list of scientific publications on Carragelose(R), https://www.carragelose.com/en/publications. 
About Marinomed Biotech AG 
Marinomed Biotech AG (Korneuburg, Austria) (VSE:MARI) is an Austrian science-based biotech company with globally 
marketed therapeutics listed on the Prime Market of the Vienna Stock Exchange. The company focuses on the development 
of innovative products based on two patent-protected technology platforms. The Marinosolv(R) technology platform 
increases the efficacy of hardly soluble compounds for the treatment of sensitive tissues such as eyes, nose, lung or 
gastrointestinal tract. The Carragelose(R) platform comprises innovative patent-protected products targeting viral 
infections of the respiratory tract and can reduce the risk of an infection with SARS-CoV-2. Carragelose(R) is used in 
nasal sprays, throat sprays and lozenges, which are sold via international partners in over 40 countries worldwide. 
Marinomed, Marinosolv(R) and Carragelose(R) are registered trademarks of Marinomed AG. These trademarks may be owned or 
licensed in select locations only. Further information is available at https://www.marinomed.com/en/ 
technologies-markets/markets. 
For further inquiries contact: 
Marinomed Biotech AG                         International Media and IR Contact 
Dr. Eva Prieschl-Grassauer, CSO              MC Services AG 
Hovengasse 25, 2100 Korneuburg, Austria      Dr. Brigitte Keller, Julia Hofmann 
T +43 2262 90300                             T +49 89 210228 0 
E-mail: eva.prieschl@marinomed.com           UK: Shaun Brown 
http://www.marinomed.com                     M: +44 7867 515 918 
                                             E-mail: marinomed@mc-services.eu Disclaimer 

This press release contains forward-looking statements, which are based on current views, expectations and projections of the management of Marinomed Biotech AG about future events. These forward-looking statements are subject to risks, uncertainties and assumptions that could cause actual results, performance or events to differ materially from those described in, or expressed or implied by, such statements. The current views, expectations and projections of the management of Marinomed Biotech AG may be identified by the context of such statements or words such as "anticipate," "believe", "estimate", "expect", "intend", "plan", "project" and "target". Forward-looking statements are only valid as of the date they are made and Marinomed Biotech AG does not assume any obligation to update, review or revise any forward-looking statements contained in this press release whether as a result of new information, future developments or otherwise. ^[*] Full scientific name is P1 (L18F T20N P26S D138Y R190S K417T E484K N501Y D614G H655Y T1027I) ^[1]https://www.medrxiv.org/content/10.1101/2021.04.13.21255409v1.full.pdf ^[2]https://www.marinomed.com/en/news/ marinomed-biotech-ag-shares-positive-clinical-trial-results-for-iota-carrageenan-nasal-spray-in-the-prevention-of-covid-19-1 -----------------------------------------------------------------------------------------------------------------------

2021-04-21 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. The issuer is solely responsible for the content of this announcement. The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at www.dgap.de -----------------------------------------------------------------------------------------------------------------------

1186801 2021-04-21

 
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(END) Dow Jones Newswires

April 21, 2021 01:45 ET (05:45 GMT)

Stocks mentioned in the article
ChangeLast1st jan.
DJ INDUSTRIAL -0.86% 34795.64 Delayed Quote.13.83%
IOTA (IOT/BTC) 0.00% 2.2E-5 Real-time Quote.120.00%
IOTA (IOT/ETH) -3.86% 0.000324 Real-time Quote.-16.38%
IOTA (IOT/EUR) 3.29% 0.73632 Real-time Quote.194.43%
IOTA (IOT/USD) 3.27% 0.87252 Real-time Quote.185.86%
MARINOMED BIOTECH AG 0.45% 111.5 Delayed Quote.-6.72%
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