Nearly 80% of its salaried U.S. workforce self-reported that they are fully vaccinated, the company said.
The Chrysler parent said all workers would need to submit proof of their vaccination status by Dec. 4 and receive their final dose by Jan. 5.
The company said in a memo to employees the action was also "in preparation for a phased reopening of our offices in 2022."
Earlier this month, Ford Motor Co said it would require most of its 32,000-strong U.S. salaried workforce to be vaccinated.
The second largest U.S. automaker earlier this month said more than 84% of U.S. salaried employees already are vaccinated.
Ford said earlier it was still evaluating its policy for "manufacturing locations, parts depots and Ford Credit, including analyzing federal and collective bargaining requirements."
Detroit's Big Three automakers - General Motors Co, Ford and Stellantis - said last month they would mandate vaccines for autoworkers in Canada.
GM declined to say Friday if it would require vaccines for U.S. salaried employees.
"GM is reviewing the rules with multiple internal and external stakeholders and determining the actions we must take to ensure company-wide understanding and compliance," a spokeswoman said.
(Reporting by Deborah Sophia in Bengaluru and David Shepardson in Washington; Editing by Sriraj Kalluvila and Jonathan Oatis)
By David Shepardson
