The KXL pipeline was planned to carry 830,000 barrels per day of heavy crude across the border from Alberta to Nebraska, but U.S. President Joe Biden revoked a key permit for the project on his first day in office.
TC Energy said the impairment charge was related to halting work on KXL and a reassessment of related projects like the Heartland Pipeline.
"We were very disappointed with the decision in January to revoke the presidential permit," Chief Executive Francois Poirier said on an earnings call, adding the company was "opportunity-rich" in other parts of its business.
Calgary-based TC Energy owns the largest network of natural gas pipelines in North America as well as the existing Keystone oil pipeline and power and storage assets.
The company posted a C$2.51 billion loss from its oil pipelines, of which Keystone is the biggest contributor, compared with a C$411 million profit in the same period last year.
It reported net loss attributable to shareholders of C$1.1 billion, or C$1.11 per share, in the three months ended March 31 compared with a profit of C$1.1 billion a year earlier.
Excluding items, the company earned C$1.16 per share, slightly better than analysts' average estimate of C$1.10, according to Refinitiv IBES data.
TC Energy shares closed up 0.2% on the Toronto Stock Exchange at C$61.94.
($1 = 1.2176 Canadian dollars)
(Reporting by Shariq Khan in Bengaluru and Nia Williams in Calgary; Editing by Arun Koyyur and Marguerita Choy)
By Nia Williams and Shariq Khan