The investment initiative will harness up to $5 billion in private funds for rural areas over three years, U.S. National Security Advisor Robert O'Brien told local newspaper El Tiempo in an interview.
"This initiative will focus on key elements of the 21st-century growth in Colombia, the rule of law, security, infrastructure, rural development and democracy," O'Brien said in a joint video statement with Ivan Duque.
Colombia will be part of a pilot program meant to incentivize near-shoring of U.S. businesses, part of a larger U.S. strategy announced on Monday.
Mauricio Claver-Carone, special adviser to U.S. President Donald Trump for the Western Hemisphere, was also on the visit.
Duque repeated Colombia's support for Claver-Carone in his bid to lead the Inter-American Development Bank (IDB), which is set to choose a new head next month.
Haiti and El Salvador on Monday joined Guyana in co-nominating Claver-Carone as their own candidates.
But several other Latin American countries have called for a vote delay, citing concerns over having an IDB leader from outside the region.
"I want to reaffirm the support Colombia has given to the candidacy of Mauricio Claver," Duque said. "You have presented a clear agenda to invigorate the recovery of Latin American economies."
The United States unveiled a Western Hemisphere strategy on Monday focused on security, economic growth and countering China's influence in the region.
The strategy aims to encourage U.S. companies to move manufacturing facilities and supply chains out of China and back to the Americas, a U.S. National Security Council official said.
The strategy also vows to maintain maximum pressure on rulers in Venezuela, Cuba and Nicaragua.
The trip comes as Trump seeks to build support for his re-election campaign as Democrat Joe Biden leads in national polls. The Trump re-election campaign this year increased its outreach to Latinos.
(Reporting by Julia Symmes Cobb in Bogota and Andrea Shalal in Washington; editing by Richard Pullin & Shri Navaratnam)