The Nasdaq dropped most among major indexes on Tuesday and now has fallen about 9.7% from its Nov. 19 record closing high, close to confirming a 10% correction for the first time since early 2021. The tech-heavy index also closed below its 200-day moving average, a key technical support level, for the first time since April 2020.

Goldman Sachs shares tumbled 7% after the investment bank missed quarterly profit expectations amid weak trading activity. The financials sector, which has been one of the better-performing groups in 2022, dropped 2.3%.

"The financials crumbling a little bit under the weight of less-than-impressive earnings quarters is probably the biggest factor today," said Chuck Carlson, chief executive officer at Horizon Investment Services in Hammond, Indiana. "When you have taken out potentially one of the areas that actually was working here, that kind of casts a pall on the market."

Benchmark U.S. Treasury yields jumped to two-year highs and two-year yields breached 1% as traders prepared for the Federal Reserve to be more aggressive in tackling unabated inflation.

The steep ascent in yields to start 2022 has weighed in particular on tech and growth stocks, whose future expected cash flows are discounted more sharply as yields rise.

"The hot inflation prints have spooked the market that the Fed is going to move and so we are seeing this rise in yields," said Mona Mahajan, senior investment strategist at Edward Jones.

"It's not only the rise in yields but the rapid rise in yields ... that really does cause some indigestion in the market, but particularly in growth, higher valuation, more speculative asset classes," Mahajan said.

The Dow Jones Industrial Average fell 543.34 points, or 1.51%, to 35,368.47, the S&P 500 lost 85.74 points, or 1.84%, to 4,577.11 and the Nasdaq Composite dropped 386.86 points, or 2.6%, to 14,506.90.

Of 11 S&P 500 sectors, 10 ended lower, with technology falling the most. Energy, the top-percentage gainer so far in 2022, was the lone sector in positive territory, rising 0.4%.

Declines in megacap stocks, including Microsoft, Apple and Meta Platforms, weighed heavily on the S&P 500 among individual shares.

A BofA survey showed that fund managers had cut their overweight positions in tech to their lowest levels since 2008, while another survey by Deutsche Bank found that a majority of respondents believed U.S. technology stocks are in bubble territory.

Investors are zeroing in on next week's Fed policy meeting for more clarity on central bankers' next moves to rein in inflation. Data last week showed U.S. consumer prices increased solidly in December, culminating in the largest annual rise in inflation in nearly four decades.

In company news, Activision shares soared nearly 26% after Microsoft announced a deal to buy the video-game maker for $68.7 billion. Shares of other video game companies rose, with Electronic Arts up 2.7% and Take-Two Interactive Software up 1%. Microsoft shares fell 2.4%.

Declining issues outnumbered advancing ones on the NYSE by a 5.52-to-1 ratio; on Nasdaq, a 4.93-to-1 ratio favored decliners.

The S&P 500 posted 34 new 52-week highs and nine new lows; the Nasdaq Composite recorded 69 new highs and 611 new lows.

About 11.9 billion shares changed hands in U.S. exchanges, compared with the 10 billion daily average over the last 20 sessions.

(Reporting by Bansari Mayur Kamdar, Shreyashi Sanyal, Sruthi Shankar in Bengaluru, Sinéad Carew and Karen Brettell in New York and Danilo Masoni in Milan; Editing by Maju Samuel and Lisa Shumaker)

By Lewis Krauskopf, Bansari Mayur Kamdar and Shreyashi Sanyal