Spyre Therapeutics, Inc. reported earnings results for the fourth quarter and full year ended December 31, 2025. For the fourth quarter, the company reported net loss was USD 62.53 million compared to USD 56.3 million a year ago. Basic loss per share from continuing operations was USD 0.7 compared to USD 0.81 a year ago. Diluted loss per share from continuing operations was USD 0.7 compared to USD 0.81 a year ago.
For the full year, net loss was USD 155.2 million compared to USD 208.02 million a year ago. Basic loss per share from continuing operations was USD 1.98 compared to USD 3.18 a year ago.
Spyre Therapeutics, Inc. is a biotechnology company. The Company is engaged in creating inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations and precision medicine approaches. Its pipeline includes investigational extended half-life antibodies targeting a4B7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, and SPY230. It has nominated development candidates for SPY001 and SPY002. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4B7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a discovery-stage program focused on designing antibodies to bind to Interleukin 23 (IL-23).
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