May 21 (Reuters) - Futures linked to Canada's main stock index inched lower on Thursday, as uncertainty around U.S.-Iran peace talks weighed on sentiment, while AI chipmaker Nvidia's earnings failed to excite investors.

June futures on the S&P/TSX index were down 0.2% at 6:52 a.m. ET (1052 GMT).

o Iran's Supreme Leader has issued a directive that the country's near-weapons-grade uranium should not be sent abroad, two senior Iranian sources said, hardening Tehran's stance on one of the main U.S. demands in ongoing negotiations.

o Oil prices climbed more than 2% following the news. [O/R]

o Spot gold and silver fell 0.7% and 1.7%, respectively, pressured by a stronger U.S. dollar and high Treasury yields. [GOL/]

o Shares of Nvidia edged up just 0.2% in U.S. premarket trading even after the AI heavyweight forecast second-quarter revenue above Wall Street estimates and announced an $80 billion share repurchase program.

o The Toronto Stock Exchange's S&P/TSX posted its biggest advance in nearly three weeks on Wednesday, with financials and metal mining shares contributing to broad-based gains.

o Investors were also tracking Elon Musk's SpaceX after the company unveiled its IPO filing on Wednesday, opening its books ahead of what could be the first trillion-dollar U.S. market debut.

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(Reporting by Tharuniyaa Lakshmi in Bengaluru; Editing by Jonathan Ananda)