The continent-wide STOXX 600 index rose 0.1% to 494.35 points, its third consecutive record closing high.

But a recent rally appeared to be losing traction, amid concerns over the omicron coronavirus variant, rising interest rates and mixed economic data.

The European automobile subindex was the best performer, jumping 2.7% to a record high as investors expected production to roar back from a semiconductor shortage, with car sales also likely to improve.

Germany's BMW added 2.2% after it achieved record sales from its BMW brand in 2021.

But JPMorgan took a cautious stance for the sector in 2022, citing consumer uncertainty over electric vehicles in Europe.

"We... see a sharper recovery in 2H22 as additional chip capacity comes online," analysts at the investment bank wrote. The bank is also overweight on automakers such as Daimler and Renault, as well as tyremakers Michelin and Nokian.

Renault jumped 5.3% to the top of France's CAC 40 after Qualcomm announced deals to supply chips to automakers including the French carmaker.

Mining stocks rose 1.6%, tracking stronger commodity prices as investors bet that demand would recover from a COVID-induced lull.

Other economically-exposed sectors also gained, with banks up 0.2% on expectations of higher interest rates.

Technology stocks fell 0.5% as the prospect of higher rates made the sector appear less attractive.

"There are wobbles in the global equity markets on the back of higher back-end U.S. Treasury yields and concerns about the Chinese tech sector," Sebastien Galy, senior macro strategist at Nordea Asset Management, said.

"We should see the fear ebb to leave us with the shape of a reality that is less clear cut than post COVID-19 shock."

Data also painted a mixed picture of the euro zone economy, as a survey showed a recovery faltered in December due to a resurgence in COVID-19 infections.

Among other movers, Nestle slipped 2.7%, and was among the top drags on the STOXX 600 after Jefferies downgraded the firm on expectations that its margins would remain under pressure from commodity cost inflation.

Valneva fell for the seventh consecutive day amid uncertainty over its COVID-19 vaccine candidate.

(Reporting by Sruthi Shankar in Bengaluru; Editing by Subhranshu Sahu, Aditya Soni and Alexander Smith)

By Sruthi Shankar and Ambar Warrick