After rising as much as 0.8% in afternoon trade, the blue-chip index closed 0.3% higher, boosted by aero and pharmaceutical stocks, with energy and mining shares also tracking commodity prices higher.
The domestically focused mid-cap FTSE 250 ended flat, after rising 0.5% during the day.
Data showed British retail sales rose a higher-than-anticipated 1.2% in October ahead of the recent restrictions, while consumer confidence sank to a six-month low in November.
A Reuters poll found Britain is on course for a double-dip recession as a result of the renewed lockdown measures.
"We are having catch-up of exuberance around a possible vaccine and an end to the COVID-19 uncertainty," said Edward Park, chief investment officer at Brooks Macdonald.
"Market is taking all data with a pinch of salt because there's so much uncertainty about how the level of restrictions will need to be over the coming few weeks."
Meanwhile, UK Health Secretary said Britain may allow a Christmas period with less stringent restrictions as domestic coronavirus cases were starting to flatten.
The FTSE 100 rose only 0.5% for the week, following a jump of about 13% in the past two weeks, as uncertainty over Brexit negotiations also capped gains.
The EU's chief executive said on Friday better progress towards a trade deal with Britain had been made the last few days, but there was still a lot of work to do for an agreement to be in place by the end-year deadline.
Among other stock movers, Sage Group Plc tumbled 13.4% after the software firm reported a 3.7% drop in full-year organic operating profit.
British Land fell 1.1% after Barclays cut its target price on the stock.
(Reporting by Devik Jain in Bengaluru, Editing by Sherry Jacob-Phillips and Sriraj Kalluvila)
By Devik Jain