The FTSE 100 was little changed by 0718 GMT, with Rio Tinto falling 3.5% as the miner traded without entitlement to the latest dividend payout.
Drugmaker GSK slid 2.1% after heavy selling in the previous session amid chatter over potential negative implication from U.S. lawsuits over Zantac, a drug that was withdrawn in 2019. Haleon, a consumer health company recently spun off from GSK, dropped 4.9%.
London-listed shares of Antofagasta slipped 0.5% after the of Chilean miner reported a fall in half-year profit.
The domestically focussed FTSE 250 index rose 0.4% as European and Asian stocks climbed.
UK-listed shares of Dubai-based payments processor Network International jumped 11.3% as it announced a stock buyback programme and reported strong half-year results.
(Reporting by Sruthi Shankar in Bengaluru; editing by Uttaresh.V)