The following information should be read in conjunction with the unaudited condensed consolidated financial statements and the notes thereto included in this Quarterly Report on Form 10-Q and our Annual Report on Form 10-K for the year endedDecember 31, 2020 . Certain matters discussed in this Quarterly Report on Form 10-Q may be deemed to be forward-looking statements that involve risks and uncertainties, as well as assumptions that, if they never materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. We make such forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. In this Quarterly Report on Form 10-Q, words such as "anticipate," "believe," "contemplate," "continue," "could," "estimate," "expect," "forecast," "goal," "intend," "may," "plan," "potential," "predict," "project," "should," "strategy," "target," "vision," "will," "would," or, in each case, the negative or other variations thereon or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. The forward-looking statements in this Quarterly Report on Form 10-Q include, among other things, statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: •the impact on our business of the COVID-19 pandemic and the government's efforts to contain it; •our ongoing and planned preclinical studies and clinical trials; •clinical trial data and the timing of results of our ongoing clinical trials; •our plans to develop and commercialize sotatercept in pulmonary hypertension, ACE-1334, and our other potential therapeutic candidates; •our and Bristol Myers Squibb's, or BMS's, plans to develop and commercialize REBLOZYL® (luspatercept-aamt) and sotatercept outside of pulmonary hypertension; •the potential benefits of strategic partnership agreements and our ability to enter into selective strategic partnership arrangements; •the timing of anticipated milestone payments under our collaboration agreements with BMS; •the timing of, and our and/or BMS's ability to, obtain and maintain regulatory approvals for our therapeutic candidates; •the rate and degree of market acceptance and clinical utility of any approved therapeutic candidate, particularly in specific patient populations; •our ability to quickly and efficiently identify and develop therapeutic candidates; •our manufacturing capabilities and strategy; •our plans for commercialization and marketing; •our intellectual property position; and •our estimates regarding our results of operations, financial condition, liquidity, capital requirements, prospects, growth and strategies. By their nature, forward-looking statements involve risks and uncertainties because they relate to events, competitive dynamics, and industry change and depend on the economic circumstances that may or may not occur in the future or may occur on longer or shorter timelines than anticipated. We caution you that forward-looking statements are not guarantees of future performance and that our actual results of operations, financial condition and liquidity, and events in the industry in which we operate may differ materially from the forward-looking statements contained herein. Any forward-looking statements that we make in this Quarterly Report on Form 10-Q speak only as of the date of such statements, and we undertake no obligation to update such statements to reflect events or circumstances after the date of this Quarterly Report on Form 10-Q or to reflect the occurrence of unanticipated events. 18 -------------------------------------------------------------------------------- Table of Contents You should also read carefully the factors described in the section "Item 1A. Risk Factors" in our Annual Report on Form 10-K for the year endedDecember 31, 2020 to better understand the risks and uncertainties inherent in our business and underlying any forward-looking statements. You are advised, however, to consult any further disclosures we make on related subjects in our subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, press releases, and our website. Overview We are a biopharmaceutical company dedicated to the discovery, development and commercialization of therapeutics to treat serious and rare diseases. Our research focuses on key natural regulators of cellular growth and repair, particularly the Transforming Growth Factor-Beta, or TGF-beta, protein superfamily. By combining our discovery and development expertise, including our proprietary knowledge of the TGF-beta superfamily, and our internal protein engineering and manufacturing capabilities, we generate innovative therapeutic candidates, all of which encompass novel potential first-in-class mechanisms of action. If successful, these candidates could have the potential to significantly improve clinical outcomes for patients across these areas of high, unmet need. We focus and prioritize our commercialization, research and development activities within two key therapeutic areas: pulmonary and hematology. Pulmonary We are actively developing our lead pulmonary program, sotatercept, for the treatment of patients with pulmonary arterial hypertension, or PAH. Sotatercept is generally partnered with Bristol Myers Squibb, or BMS, (which acquired Celgene Corporation inNovember 2019 ), but we retain the exclusive rights to fund, develop, and lead the global commercialization of sotatercept in pulmonary hypertension, which we refer to as the PH field, and that includes PAH. PAH is a rare and chronic, rapidly progressing disorder characterized by the constriction of small pulmonary arteries, resulting in abnormally high blood pressure in the pulmonary arteries. InJune 2020 , we presented results of the PULSAR Phase 2 trial of sotatercept in patients with PAH on stable background PAH-specific therapies during the "Breaking News: Clinical Trials in Pulmonary Medicine" session of theAmerican Thoracic Society , or ATS, 2020Virtual Conference . Study investigators reported that the trial met its primary endpoint, pulmonary vascular resistance, and its key secondary endpoint, six-minute walk distance, and showed concordance of results across multiple additional endpoints and regardless of baseline characteristics. Sotatercept was generally well tolerated in the trial and adverse events observed in the study were generally consistent with previously published data on sotatercept in clinical trials in other patient populations. We presented additional cardiac and pulmonary function data at the virtual 2020 American Heart Association Scientific Sessions inNovember 2020 showing improvement in right ventricular-pulmonary arterial (RV-PA) coupling, which represents the match between the output of the RV and the resistance of the pulmonary vasculature, as well as improvement in RV function. InMay 2021 , we presented interim results from the ongoing 18-month open-label extension of the PULSAR trial at the ATS 2021International Conference showing consistent or improved patient responses in multiple efficacy endpoints when treated with sotatercept for up to 48 weeks. We initiated our registrational Phase 3 trial, the STELLAR trial, in patients with PAH at the end of 2020, and start-up activities are underway for the early intervention Phase 3 HYPERION trial in patients with PAH and the later intervention Phase 3 ZENITH trial inWorld Health Organization (WHO ) functional class IV PAH patients, each of which we plan to initiate in the second half of 2021. In addition, we plan to initiate the Phase 2 CADENCE trial in patients with pulmonary hypertension with left heart disease in the second half of 2021. We have completed enrollment in an exploratory study called SPECTRA to provide us with greater understanding of sotatercept's potential impact on PAH. We presented preliminary interim results inNovember 2020 at the virtual 2020 American Heart Association Scientific Sessions, and we presented additional preliminary interim results at the ATS 2021International Conference , in each case showing improvements in multiple hemodynamic measures in the first 10 patients evaluated among the total of 21 trial participants. We also previously announced that theU.S. Food and Drug Administration , or FDA, has granted Breakthrough Therapy designation to sotatercept for the treatment of patients with PAH, and that theEuropean Medicines Agency , or EMA, has granted Priority Medicines, or PRIME, designation to sotatercept for the treatment of patients with PAH. InDecember 2020 , theEuropean Commission granted Orphan Drug designation to sotatercept for the treatment of patients with PAH. If sotatercept is approved and commercialized to treat PAH, then we will recognize revenue from global net sales and owe BMS a royalty in the low 20% range. 19 -------------------------------------------------------------------------------- Table of Contents In addition to sotatercept, we are currently advancing our second pulmonary therapeutic candidate, ACE-1334. ACE-1334 is a wholly owned TGF-beta superfamily-based ligand trap designed to bind and inhibit TGF-beta 1 and 3 ligands but not TGF-beta 2. We recently completed an ascending-dose Phase 1 clinical trial in healthy volunteers, and the FDA has granted Fast Track designation to ACE-1334 in patients with systemic sclerosis-associated interstitial lung disease, or SSc-ILD, as well as Orphan Drug designation for the treatment of systemic sclerosis. SSc-ILD is a rare, progressive, autoimmune connective tissue disorder characterized by immune dysregulation. We intend to initiate a Phase 1b/Phase 2 clinical trial with ACE-1334 in patients with SSc-ILD by the end of 2021. Hematology Our first commercial product, REBLOZYL® (luspatercept-aamt), is a first-in-class erythroid maturation agent designed to promote red blood cell, or RBC, production through a novel mechanism, and is partnered with BMS. REBLOZYL is currently approved to treat certain adult patients with beta-thalassemia or MDS inthe United States ,European Union andCanada , as further described in the "Business" section in our Annual Report on Form 10-K for the year endedDecember 31, 2020 . For additional patient populations, BMS is currently conducting a Phase 2 clinical trial with luspatercept-aamt in non-transfusion-dependent beta-thalassemia patients, referred to as the BEYOND trial, and a Phase 3 clinical trial, the COMMANDS trial, in first-line, lower-risk MDS patients. InJune 2021 , we and BMS announced the first results from the BEYOND trial showing that luspatercept-aamt plus best supportive care improved anemia in 77% of patients compared to placebo, and luspatercept-aamt was generally well tolerated. Topline results from the COMMANDS trial are expected in or after 2022. In myelofibrosis, BMS is conducting a Phase 2 clinical trial with luspatercept-aamt in patients with myelofibrosis-associated anemia, and has initiated the Phase 3 INDEPENDENCE study in patients with myelofibrosis-associated anemiawho are being treated with JAK inhibitor therapy and require RBC transfusions. We believe that there is a global annual peak sales opportunity for REBLOZYL in excess of$4 billion for all currently approved indications and those in development, including future clinical development expansion. BMS is responsible for paying 100% of the development costs for all clinical trials for luspatercept-aamt. We may receive a maximum of$100.0 million for remaining potential regulatory and commercial milestone payments. We have a co-promotion right inNorth America and our commercialization costs provided in the commercialization plan and budget approved by theJoint Commercialization Committee , or JCC, are entirely funded by BMS. Activities that we elect to conduct outside of the approved development or commercialization budgets to support REBLOZYL are at our own expense. We are eligible to receive tiered royalty payments from BMS on net sales of REBLOZYL in the low-to-mid 20% range. Funding and Expense As ofJune 30, 2021 , our operations have been funded primarily by$105.1 million in equity investments from venture investors,$1.3 billion from public investors,$164.1 million in equity investments from our collaboration partners and$482.6 million in upfront payments, milestones, royalties, and net research and development payments from our collaboration partners. We expect our expenses will increase substantially in connection with our ongoing activities, if and as we: •conduct clinical trials for sotatercept in the PH field or any future therapeutic candidates; •prepare for the potential launch and commercialization of sotatercept in the PH field; •continue our preclinical studies and potential clinical development efforts of our existing preclinical therapeutic candidates; •continue research activities for the discovery of new therapeutic candidates; •manufacture therapeutic candidates for our preclinical studies and clinical trials, and potentially for commercialization; •establish and maintain a sales, marketing and distribution infrastructure to commercialize any products for which we have or may obtain regulatory approval; •acquire or in-license other therapeutic candidates and patents; •seek regulatory approval for our therapeutic candidates; and •attract and retain skilled personnel. 20 -------------------------------------------------------------------------------- Table of Contents If we obtain regulatory approval for sotatercept in the PH field, or any future therapeutic candidate, we expect to incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution to the extent that such costs are not paid by future partners. We will seek to fund our operations through royalty revenue from the sale of our first and only commercial product, REBLOZYL, and potentially from the sale of equity, debt financings or other sources, including potential additional collaborations. However, we may not generate sufficient royalty revenue and may be unable to raise additional funds or enter into such other arrangements when needed on favorable terms, or at all. If we fail to generate significant revenue or raise capital, or enter into such other arrangements as, and when, needed, we may have to significantly delay, scale back or discontinue the development or commercialization of one or more of our therapeutic candidates. Financial Operations Overview Impact of COVID-19 on our Business A novel strain of coronavirus (COVID-19) was declared a global pandemic by theWorld Health Organization (WHO ) inMarch 2020 and has caused an economic downturn on a global scale, as well as significant volatility in the financial markets. As ofJune 30, 2021 , we have not experienced material financial, development, or supply chain impacts directly related to the pandemic, but we may experience disruptions in our ongoing and planned sotatercept and ACE-1334 clinical trials. We have experienced disruptions in our commercialization efforts for REBLOZYL with regard to customer engagement and in-person promotion. New patient visits for MDS patients in general have also decreased as compared to pre-COVID levels. Although some restrictions on our in-person promotion efforts were reduced during the quarter endedJune 30, 2021 , these restrictions have begun to return recently due to an increase in COVID cases and related hospitalizations attributed to the spread of the delta variant. In addition, as various geographies inthe United States and worldwide adapt to surging COVID-19 infections from the delta variant or other new variants, we may experience additional setbacks to our operations, including our clinical trial initiations and enrollment, that could have a material impact on our business. For a discussion of the risks presented by the COVID-19 pandemic to our results, see Risk Factors in Part I, Item 1A of the Company's Annual Report on Form 10-K for the year endedDecember 31, 2020 . Revenue Collaboration Revenue Our revenue to date has been predominantly derived from collaboration revenue, which includes license and milestone revenue, cost-sharing revenue, and royalties, generated through collaboration and license agreements with partners for the development and commercialization of our therapeutic candidates. Cost-sharing revenue represents amounts reimbursed by our collaboration partners for expenses incurred by us for research and development activities and co-promotion activities under our collaboration agreements. Cost-sharing revenue is recognized in the period that the related activities are performed. Royalty revenue is recognized in the period that the related sales occur. Costs and Expenses Research and Development Expenses Research and development expenses consist primarily of costs directly incurred by us for the development of our therapeutic candidates, which include: •direct employee-related expenses, including salaries, benefits, travel and stock-based compensation expense of our research and development personnel; •expenses incurred under agreements with clinical research organizations, or CROs, and investigative sites that will conduct our clinical trials; •the cost of acquiring and manufacturing preclinical and clinical study materials, including costs incurred under agreements with contract manufacturing organizations, or CMOs, and developing manufacturing processes; •allocated facilities, depreciation, and other expenses, which include rent and maintenance of facilities, insurance and other supplies; •expenses associated with obtaining and maintaining patents; and •costs associated with preclinical activities and regulatory compliance. 21 -------------------------------------------------------------------------------- Table of Contents Research and development costs are expensed as incurred. Costs for certain development activities are recognized based on an evaluation of the progress to completion of specific tasks using information and data provided to us by our vendors and our clinical sites. We cannot determine with certainty the duration and completion costs of the current or future clinical trials of our therapeutic candidates or if, when, or to what extent we will generate revenues from the commercialization and sale of any of our therapeutic candidates for which we or any partner obtain regulatory approval. We or our partners may never succeed in achieving regulatory approval for any of our therapeutic candidates beyond the initial approvals of REBLOZYL. The duration, costs and timing of clinical trials and development of therapeutic candidates will depend on a variety of factors, including: •the scope, rate of progress, and expense of our ongoing, as well as any additional, clinical trials and other research and development activities; •future clinical trial results; •potential changes in government regulation; and •the timing and receipt of any regulatory approvals. A change in the outcome of any of these variables with respect to the development of a therapeutic candidate could mean a significant change in the costs and timing associated with the development of that therapeutic candidate. For example, if the FDA, or another regulatory authority were to require us to conduct clinical trials beyond those that we currently anticipate will be required for the completion of the clinical development of therapeutic candidates, or if we experience significant delays in the enrollment in any clinical trials, we could be required to expend significant additional financial resources and time on the completion of clinical development. From inception throughJune 30, 2021 , we have incurred$1.1 billion in research and development expenses. We plan to increase our research and development expenses for the foreseeable future as we continue the development of our TGF-beta platform therapeutic candidates, the discovery and development of preclinical therapeutic candidates, and the development of our clinical programs. Research and development expenses associated with luspatercept-aamt, and, outside of the PH field, sotatercept, are generally reimbursed 100% by BMS. These reimbursements are recorded as cost-sharing revenue. We are expensing the costs of clinical trials for sotatercept and ACE-1334. With respect to the luspatercept-aamt clinical trials directly conducted by BMS, we do not incur and are not reimbursed for expenses related to these development activities. We manage certain activities such as clinical trial operations, manufacture of therapeutic candidates, and preclinical animal toxicology studies through third-party CROs and CMOs. The only costs we track by each therapeutic candidate are external costs such as services provided to us by CROs, manufacturing of preclinical and clinical drug product by CMOs, and other outsourced research and development expenses. We do not assign or allocate to individual development programs internal costs such as salaries and benefits, facilities costs, lab supplies, and the costs of preclinical research and studies, except for luspatercept-aamt costs for the purposes of billing BMS. Our external research and development expenses during the three and six months endedJune 30, 2021 and 2020 are as follows (certain prior year amounts have been reclassified to conform with current year presentation): Three Months Ended June 30, Six Months Ended June 30, (in thousands) 2021 2020 2021 2020 Sotatercept (1)$ 17,655 $ 8,744 $ 38,628 $ 17,724 ACE-083 (2) 14 2,338 171 6,524 ACE-1334 (3) 1,746 1,620 2,936 3,380 Total direct research and development expenses 19,415 12,702 41,735 27,628 Other expenses (4) 36,715 25,549 71,694 48,289 Total research and development expenses$ 56,130 $ 38,251 $ 113,429 $ 75,917
(1)These expenses are associated with our development of sotatercept in PAH.
(2)Development of ACE-083 was discontinued. All remaining material expenses were incurred as of the end of 2020.
(3)These expenses are associated with our development of ACE-1334 in SSc-ILD.
(4)Other expenses include employee and unallocated contractor-related expenses, facility expenses, lab supplies, and miscellaneous expenses, including expenses associated with preclinical and other development programs. 22
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Selling, General and Administrative Expenses Selling, general and administrative expenses consist primarily of salaries and related costs for personnel, including stock-based compensation and travel expenses for our employees in executive, commercial, operational, finance and human resource functions. Selling, general and administrative expenses also include directors' fees, professional fees for accounting and legal services, other miscellaneous costs associated with supporting our sales, marketing and investor relations activities, and allocated facilities, depreciation, and other expenses, such as rent and maintenance of facilities, insurance and other supplies. We anticipate that our selling, general and administrative expenses will increase in the future as we increase our headcount to support our continued research and development and potential commercialization of our therapeutic candidates. Additionally, if and when we believe regulatory approval of a therapeutic candidate appears likely, to the extent that we are undertaking commercialization of such therapeutic candidate ourselves, we anticipate an increase in payroll and related expenses as a result of our preparation for commercial operations. Other Income (Expense), Net Other income (expense), net consists primarily of interest income earned on cash, cash equivalents and investments. Prior to 2021, other income (expense), net also consists of the re-measurement gain or loss associated with the change in the fair value of our common stock warrant liabilities. Critical Accounting Policies and Estimates Our management's discussion and analysis of our financial condition and results of operations are based on our condensed consolidated financial statements, which have been prepared in accordance withU.S. generally accepted accounting principles. The preparation of these condensed consolidated financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, and expenses and the disclosure of contingent assets and liabilities in our condensed consolidated financial statements. On an ongoing basis, we evaluate our estimates and judgments, including those related to revenue recognition and accrued and prepaid clinical expenses. We base our estimates on historical experience, known trends and events, and various other factors that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. During the three and six months endedJune 30, 2021 , there have been no material changes to our critical accounting policies as reported in our Annual Report on the Form 10-K for the year endedDecember 31, 2020 . For further information on our critical and other significant accounting policies, see the notes to the condensed consolidated financial statements appearing elsewhere in this Quarterly Report on Form 10-Q and our Annual Report on Form 10-K for the year endedDecember 31, 2020 . 23
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Results of Operations
Comparison of the Three Months Ended
Three Months Ended Increase (Decrease) June 30, (in thousands) 2021 2020 $ % Revenue: Collaboration revenue: Milestone $ -$ 25,000 $ (25,000) (100) % Cost-sharing, net 2,294 3,678 (1,384) (38) % Royalty 25,646 11,074 14,572 132 % Total revenue (all amounts are with a related party) 27,940 39,752 (11,812) (30) % Costs and expenses: Research and development 56,130 38,251 17,879 47 % Selling, general and administrative 35,472 20,414 15,058 74 % Total costs and expenses 91,602 58,665 32,937 56 % Loss from operations (63,662) (18,913) (44,749) 237 % Other income, net 149 466 (317) (68) % Loss before income taxes (63,513) (18,447) (45,066) 244 % Income tax provision (8) (4) (4) 100 % Net loss$ (63,521) $ (18,451) $ (45,070) 244 % Revenue. We recognized revenue of$27.9 million in the three months endedJune 30, 2021 , compared to$39.8 million in the same period in 2020. All of the revenue in both periods was derived from the BMS agreements. This$11.8 million decrease is primarily related to a decrease of$25.0 million in license and milestone revenue, partially offset by increased royalty revenue from REBLOZYL sales recognized in 2021 of$14.6 million . Research and Development Expenses. Research and development expenses were$56.1 million in the three months endedJune 30, 2021 , compared to$38.3 million in the same period in 2020. This$17.9 million increase is primarily related to growth in order to support our wholly-owned therapeutic candidates and preclinical programs and includes: •an increase in external clinical trial expense of$12.0 million primarily related to increased clinical activities for the sotatercept clinical trials; •an increase in personnel and facilities-related expense of$9.5 million related to increased headcount to support our growth; and •an increase in miscellaneous research expense of$0.8 million ; offset by •a decrease in contract manufacturing, drug supply, and development expenses of$4.1 million related to our ongoing clinical and preclinical programs. Selling, General and Administrative Expenses. Selling, general and administrative expenses were$35.5 million in the three months endedJune 30, 2021 , compared to$20.4 million in the same period in 2020. The$15.1 million increase is primarily due to the following factors: •an increase in personnel and facilities-related expense of$8.7 million related to increased headcount to support our growth; and •an increase in consulting and other miscellaneous expenses of$5.9 million primarily related to the preparation for the potential future commercial launch of sotatercept and other activities related to the execution of our global strategy. 24 -------------------------------------------------------------------------------- Table of Contents Comparison of the Six Months EndedJune 30, 2021 and 2020 Six Months Ended Increase (Decrease) June 30, (in thousands) 2021 2020 $ % Revenue: Collaboration revenue: Milestone $ -$ 25,000 $ (25,000) (100) % Cost-sharing, net 4,656 6,502 (1,846) (28) % Royalty 48,042 12,594 35,448 281 % Total revenue (all amounts are with a related party) 52,698 44,096 8,602 20 % Costs and expenses: Research and development 113,429 75,917 37,512 49 % Selling, general and administrative 66,534 38,663 27,871 72 % Total costs and expenses 179,963 114,580 65,383 57 % Loss from operations (127,265) (70,484) (56,781) 81 % Other income, net 286 1,113 (827) (74) % Loss before income taxes (126,979) (69,371) (57,608) 83 % Income tax provision (13) (20) 7 (35) % Net loss$ (126,992) $ (69,391) $ (57,601) 83 % Revenue. We recognized revenue of$52.7 million in the six months endedJune 30, 2021 , compared to$44.1 million in the same period in 2020. All of the revenue in both periods was derived from the BMS agreements. This$8.6 million increase is primarily related to increased royalty revenue from REBLOZYL sales recognized in 2021 of$35.4 million , partially offset by decreased license and milestone revenue of$25.0 million . Research and Development Expenses. Research and development expenses were$113.4 million in the six months endedJune 30, 2021 , compared to$75.9 million in the same period in 2020. This$37.5 million increase is primarily related to growth in order to support our wholly-owned therapeutic candidates and preclinical programs and includes: •an increase in personnel and facilities-related expense of$19.1 million related to increased headcount to support our growth; •an increase in external clinical trial expense of$18.8 million related to increased clinical activities for the sotatercept clinical trials; and •an increase in miscellaneous research expense of$2.1 million ; offset by •a decrease in contract manufacturing, drug supply, and development expenses of$2.0 million related to our ongoing clinical and preclinical programs. Selling, General and Administrative Expenses. Selling, general and administrative expenses were$66.5 million in the six months endedJune 30, 2021 , compared to$38.7 million in the same period in 2020. The$27.9 million increase is primarily due to the following factors: •an increase in personnel and facilities-related expense of$15.8 million related to increased headcount to support our growth; and •an increase in consulting and other miscellaneous expenses of$11.9 million primarily related to the preparation for the potential future commercial launch of sotatercept and other activities related to the execution of our global strategy. 25
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Liquidity and Capital Resources We have incurred losses and cumulative negative cash flows from operations since our inception inJune 2003 , and as ofJune 30, 2021 , we had an accumulated deficit of$1.0 billion . We anticipate that we will continue to incur losses for at least the next several years. We expect that our research and development and selling, general and administrative expenses will continue to increase and, as a result, we may need additional capital to fund our operations, which we may raise through a combination of the sale of equity, debt financings or other sources, including potential additional collaborations. As ofJune 30, 2021 , our operations have been primarily funded by$105.1 million in equity investments from venture investors,$1.3 billion from public investors,$164.1 million in equity investments from our collaboration partners, and$482.6 million in upfront payments, milestones, royalties, and net research and development payments from our collaboration partners. As ofJune 30, 2021 , we had$712.5 million in cash, cash equivalents and investments. Cash in excess of immediate requirements is invested in accordance with our investment policy, primarily with a view to liquidity and capital preservation. Cash Flows The following table sets forth the primary sources and uses of cash for each of the periods set forth below (in thousands): Six Months Ended June 30, (in thousands) 2021 2020 Net cash (used in) provided by: Operating activities$ (152,339) $ (89,401) Investing activities (188,347) 107,426 Financing activities 5,933 27,819
Net (decrease) increase in cash, cash equivalents and restricted cash
$ (334,753) $ 45,844 Operating Activities Net cash used in operating activities was$152.3 million for the six months endedJune 30, 2021 , compared to$89.4 million during the same period in 2020. Significant factors in this$62.9 million increase include: •an increase in net loss of$57.6 million primarily due to an increase in operating expenses related to increased headcount and facilities, external expenses for contract manufacturing, prepayment of phase 3 clinical trial activities and the related expense, consulting, and other external expenses to support our wholly-owned therapeutic programs, as well as expenses for commercial activities for REBLOZYL, offset by an increase in royalty revenue associated with sales of REBLOZYL; •a net increase in operating assets and liabilities of$15.7 million , consisting primarily of an increase in prepaid expenses and other assets of$39.9 million ; offset by a net decrease in collaboration receivables and accounts payable of$29.4 million and$9.8 million , respectively; and •a net increase in other non-cash expenses of$10.3 million , largely related to an increase in stock-based compensation expense of 15.3 million, and offset by a net decrease in amortization and accretion of premiums and discounts on available-for-sale securities of 3.4 million. Investing Activities Net cash used in investing activities was$188.3 million for the six months endedJune 30, 2021 , compared to net cash provided by investing activities of$107.4 million during the same period in 2020. Net cash used and provided by investing activities primarily consisted of the following amounts relating to activity within our investment portfolio: •for the six months endedJune 30, 2021 , purchases of investments of$186.5 million net of maturities due to the execution of our investment strategy in accordance with our policy as we invest the money raised in ourJuly 2020 public offering in marketable securities; and •for the six months endedJune 30, 2020 , net proceeds from sales and maturities of investments of$109.8 million in connection with managing our investment portfolio to meet our projected cash requirements. 26 -------------------------------------------------------------------------------- Table of Contents Financing Activities Net cash provided by financing activities was$5.9 million for the six months endedJune 30, 2021 , compared to$27.8 million during the same period in 2020. Net cash provided by financing activities consisted primarily of the following: •for the six months endedJune 30, 2021 ,$5.9 million in cash proceeds from the exercise of stock options and the issuance of common stock related to the employee stock purchase plan; and •for the six months endedJune 30, 2020 ,$27.8 million in cash proceeds from the exercise of stock options and the issuance of common stock related to the employee stock purchase plan. Operating Capital Requirements To date, we have only generated limited revenue from royalties on the sale of our first and only commercial product, REBLOZYL, since receiving our first regulatory approval from the FDA inNovember 2019 . We expect our expenses to increase and to incur losses as we continue the development of, and seek regulatory approvals for, sotatercept in the PH field and any future therapeutic candidates, and as we begin to commercialize any approved products. We are subject to all of the risks inherent in the development of therapeutic candidates, and we may encounter unforeseen expenses, difficulties, complications, delays and other unknown factors that may adversely affect our business. Based on our current operating plan and projections, we believe that our current cash, cash equivalents and investments, along with the expected royalty revenue from REBLOZYL sales, will be sufficient to fund our projected operating requirements for the foreseeable future. Until we can generate a sufficient amount of revenue from our products, if ever, we expect to fund our operations through a combination of equity offerings, debt financings or other sources, including potential additional collaborations. Additional capital may not be available on favorable terms, if at all. If we are unable to generate sufficient revenue or raise additional capital in sufficient amounts or on terms acceptable to us, we may have to significantly delay, scale back or discontinue the development or commercialization of one or more of our therapeutic candidates. If we raise additional funds through the issuance of additional debt or equity securities, it could result in dilution to our existing stockholders and increased fixed payment obligations, and these securities may have rights senior to those of our common stock. If we incur indebtedness, we could become subject to covenants that would restrict our operations and potentially impair our competitiveness, such as limitations on our ability to incur additional debt, limitations on our ability to acquire, sell or license intellectual property rights and other operating restrictions that could adversely impact our ability to conduct our business. We may not be able to enter into new collaboration arrangements for any of our proprietary therapeutic candidates. Any of these events could significantly harm our business, financial condition and prospects. Our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement and involves risks and uncertainties, and actual results could vary as a result of a number of factors. We have based this estimate on assumptions that may prove to be wrong, and we could utilize our available capital resources sooner than we currently expect. Our future funding requirements, both near and long-term, will depend on many factors, including, but not limited to: •the achievement of milestones under our agreements with BMS;
•the amount of royalties we receive on sales of REBLOZYL;
•the terms and timing of any other collaborative, licensing and other arrangements that we may establish;
•the initiation, progress, timing and completion of preclinical studies and clinical trials for our therapeutic candidates and potential therapeutic candidates;
•the number and characteristics of therapeutic candidates that we pursue;
•the progress, costs and results of our clinical trials;
•the outcome, timing and cost of regulatory approvals;
•delays that may be caused by changing regulatory requirements;
•the cost and timing of hiring new employees to support our continued growth, including potential new facilities;
27 -------------------------------------------------------------------------------- Table of Contents •the costs involved in filing and prosecuting patent applications and enforcing and defending patent claims;
•the costs and timing of procuring clinical and commercial supplies of our therapeutic candidates;
•the costs of preparing for the potential launch and commercialization of sotatercept or our other therapeutic candidates;
•the extent to which we acquire or invest in businesses, products or technologies; and
•the costs involved in defending and prosecuting litigation regarding in-licensed or wholly-owned intellectual property.
Net Operating Loss (NOL) Carryforwards We had net deferred tax assets of approximately$282.2 million as ofDecember 31, 2020 , which have been fully offset by a valuation allowance due to uncertainties surrounding our ability to realize these tax benefits. The deferred tax assets are primarily composed of federal and state tax net operating loss, or NOL, carryforwards, research and development tax credit carryforwards, and deferred revenue, accruals and other temporary differences. As ofDecember 31, 2020 , we had federal NOL carryforwards of approximately$871.4 million and state NOL carryforwards of$788.3 million available to reduce future taxable income, if any. Of these federal and state NOL carryforwards,$438.0 million and$787.7 million , respectively, will expire at various times through 2040. The federal NOL of$433.4 million and state NOL of$0.6 million generated beginning in 2018 can be carried forward indefinitely. In general, if we experience a greater than 50% aggregate change in ownership of certain significant stockholders over a three-year period, or a Section 382 ownership change, utilization of our pre-change NOL carryforwards are subject to an annual limitation under Section 382 of the Internal Revenue Code of 1986, as amended, and similar state laws. Such limitations may result in expiration of a portion of the NOL carryforwards before utilization and may be substantial. If we experience a Section 382 ownership change in connection with our public offerings or as a result of future changes in our stock ownership, some of which changes are outside our control, the tax benefits related to the NOL carryforwards may be limited or lost. For additional information about our taxes, see Note 13 to the financial statements in our Annual Report on Form 10-K for the year endedDecember 31, 2020 . Contractual Obligations and Commitments
During the three months ended
Recent Accounting Pronouncements For a summary of recently issued accounting pronouncements applicable to the Company refer to Note 2, "Summary of Significant Accounting Policies" in the Notes to our audited Consolidated Financial Statements included in our Annual Report on Form 10-K for the year endedDecember 31, 2020 . Off-Balance Sheet Arrangements We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements, as defined in the rules and regulations of theSecurities and Exchange Commission . Item 3. Quantitative and Qualitative Disclosures About Market Risks We are exposed to market risk related to changes in interest rates. As ofJune 30, 2021 andDecember 31, 2020 , we had cash, cash equivalents and investments of$712.5 million and$857.5 million , respectively. Our cash equivalents are invested primarily in bank deposits and money market mutual funds. Our primary exposure to market risk is interest rate sensitivity, which is affected by changes in the general level ofU.S. interest rates. Our investments are subject to interest rate risk and could fall in value if market interest rates increase. Due to the duration of our investment portfolio and the low risk profile of our investments, we do not believe an immediate 100 basis point change in interest rates would have a material impact on the fair market value of our portfolio. We have the ability to hold our investments until maturity, and therefore we would not expect our operating results or cash flows to be affected to any significant degree by the effect of a change in market interest rates on our investments. We contract with CROs and manufacturers internationally. Transactions with these providers are predominantly settled inU.S. dollars and, therefore, we believe that we have only minimal exposure to foreign currency exchange risks. We do not hedge against foreign currency risks. 28
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