Certain Options of Achieve Life Sciences, Inc. are subject to a Lock-Up Agreement Ending on 23-AUG-2021. These Options will be under lockup for 90 days starting from 25-MAY-2021 to 23-AUG-2021. Details: The executive officers and directors have agreed to a 90-day “lock-up” with respect to shares of the common stock and other securities beneficially owned, including securities that are convertible into, or exchangeable or exercisable for, shares of the common stock. Subject to certain exceptions, during the applicable lock-up period following the date of this prospectus supplement, we and our executive officers and directors may not offer, sell, pledge or otherwise dispose of these securities without the prior written consent of Oppenheimer & Co. Inc.