On November 12, 2021, the board of directors of Aeglea Biotherapeutics, Inc. appointed Hunter Smith as a Class I director and as a member of the Audit Committee, effective immediately. Mr. Smith has served as Chief Financial Officer of Rhythm Pharmaceuticals, Inc. since July 2017 and Treasurer since August 2017. He has more than 25 years of global finance and management experience across multiple industries and financial disciplines, including expertise in business analysis and planning, mergers and acquisitions, capital raising and investor relations.