Agilent Technologies Inc. announced release of the new Seahorse XF Flex Analyzer, a high-performance, 24-well system designed to expand real-time metabolic analysis into optimized 3D tissue and organoid workflows, along with dedicated consumables and kit. Metabolism is vital for cellular functions, driving energy production and essential processes such as biosynthesis, adaptation, redox balance, mitochondrial function, and cell fate decisions. Disruptions in metabolism can lead to many diseases, making its analysis crucial for uncovering disease mechanisms and developing novel therapies.
Interest in analyzing cellular metabolism in complex 3D biological models, such as tissues, organoids, and co-cultures, has grown due to their closer emulation of in vivo conditions. These models offer more physiologically relevant insights than traditional 2D models, reflected in the rapid growth of the 3D culture market. In combination with the Seahorse XF Flex analyzer, the optimized Seahorse XF Flex tissue workflow includes several key components designed to enhance real-time metabolic analysis in live tissue models.
It features the Seahorse XF Flex 3D Capture Microplate, essential for capturing 3D tissue samples, and the Seahorse XF 3D Mito Stress Test Kit, used to measure mitochondrial function in these models. The workflow also incorporates a precision-cut vibratome, a tool that allows for the creation of consistent and smooth tissue sections, crucial for accurate metabolic analysis. Additionally, the intuitive XF software simplifies assay setup, automates data quality control, and transforms data into actionable insights with minimal effort.
These components work together to provide a comprehensive solution for researchers, ensuring higher sensitivity and consistency in their measurements. The launch of the Seahorse XF FlexAnalyzer underscores Agilent's dedication to advancing scientific research and addressing the evolving needs of researchers. This innovative system enhances its portfolio of metabolic analysis tools, known for reliability, versatility, and superior data quality.
By enabling real-time metabolic analysis in 3D models, the Seahorse XF Flexanalyzer empowers researchers to achieve groundbreaking discoveries and drive progress in biomedical research and preclinical therapeutic development.
