Air Products and Sublime Stericeuticals Corporation announced plans to collaborate and develop a proprietary sublimation and desorption technology for a continuous freeze-drying system for vaccine and drug solutions. Under a joint development agreement (JDA), Air Products' proprietary cryogen delivery and liquid nitrogen spray freezing technology will be used in combination with Sublime's process design to spray crystallize vaccine and drug solutions in a continuous sterile lyophilization freeze drying environment. Freeze-drying, or lyophilization, is regularly used to preserve biological products such as vaccines and antihemophilic proteins. It is also used to stabilize biopharmaceuticals, active pharmaceutical ingredients, and cell extracts. Solutions containing the ingredients are freeze-dried inside vials, and later reconstituted. Common quality-related process issues often greatly affect the final yield and cost to produce these products.