Ajinomoto : Strategy for Our Medical Food Business

Strategy for Our Medical Food Business Sumio Maeda Executive Officer & Senior Vice President, General Manager, Bio & Fine Chemicals Division

June 26, 2025

Ajinomoto Group's Medical Food Business

Nualtra Limited (Ireland)

• Development and sale of oral nutritional supplements

• Became a consolidated subsidiary in 2020

:

Enhanced Medical Nutrition Inc. (Canada)

· Startup specializing in surgical nutrition. Invested in 2025

Ajinomoto Co., Inc.

• Application to medical foods of

technology leveraging

"AminoScience," such as

Deliciousness Technology

Ajinomoto Cambrooke, Inc. (Massachusetts, United States)

• Development, manufacture, and sale of

  medical foods

• Became a consolidated subsidiary in 2017

Medical food is a business sector in which we expect significant future growth, leveraging our "AminoScience." We will aim to achieve further growth by expanding globally, led by Ajinomoto Cambrooke, Inc. (the U.S.) and Nualtra Limited (Ireland), as well as by leveraging our technologies and networks.

Region where we already have a business presence

２

What Are Medical Foods?

• Foods that supplement nutrition for people who have a problem consuming, digesting, absorbing, or metabolizing foods due to specific diseases or nutritional conditions.
• These foods are prescribed by or taken under the guidance of a medical professional (doctor or registered dietitian) and are used to improve the health of the patient when a specific nutritional intake is required.

Foods

Supplements

Medical foods

Pharmaceuticals

Summary	Everyday foods	Supplement nutritional intake from foods	(See above)	Taken to treat or prevent a disease
Need for prescription, etc.	No	No	Yes (With some exceptions)	Yes
Insurance or government subsidies	No	No	Yes (Depends on the country, etc.)	Yes (Depends on the country, etc.)
Marketing approval procedures	No	No	No (Registration of the product for a prescription is required)	Yes

Ajinomoto Group's Medical Food Product Lineup

Foods for inborn errors of metabolism

• Phenylketonuria (PKU)

• Amino acid metabolism disorders

• Tyrosinemia

• Low-protein foods

Foods for protein allergies

Foods for type 2 diabetes

Fluid Thickener

(For dysphagia)

Our group has developed products for people with specific diseases, such as inborn errors of metabolism, epilepsy, and protein allergies or nutritional conditions. We provide a diverse array of products that not only meet customer needs for nutritional intake, but also such needs as deliciousness or organic ingredients.

For people with specific diseases

For people

with specific nutritional conditions

Ketogenic foods

• Epilepsy

Oral nutritional supplements

Product Lineup for People with Specific Diseases

Products for people with specific diseases. Ajinomoto Cambrooke's particular area of expertise.

e.g.: Medical foods for phenylketonuria (PKU)*

*An amino acid metabolism disorder in which the amino acid phenylalanine cannot be metabolized due to an inborn enzymatic defect. It requires a lifelong special low protein diet that does not contain phenylalanine.

Activation

Coenzyme BH4

Enzyme PAH

Phenylalanine

Enzyme

Tyrosine

Metabolize/ decompose

Metabolism/decomposition in a PKU patient

Activation

Coenzyme BH4

Enzyme PAH

Phenylalanine cannot be broken down properly and foods that contain protein must be avoided.

Phenylalanine

Enzyme

Tyrosine

Metabolize/ decompose

Normal metabolism/decomposition

PKU onset mechanism