Item 1.01 Entry into a Material Definitive Agreement.

On November 30, 2020, Akebia Therapeutics, Inc. (the "Company") executed the Sixth Amendment to Lease (the "Sixth Amendment") with CLPF-Cambridge Science Center, LLC (the "Landlord"), amending the lease dated December 3, 2013, by and between the Company and the Landlord, as amended (the "Lease"), for the Company's headquarters located at 245 First Street, Cambridge, Massachusetts (the "Building").

Pursuant to the Sixth Amendment, the Company has agreed to extend the term of its existing lease of approximately 5,951 square feet of office, research and laboratory space located on the first floor of the lab building adjacent to the Building (the "Lab Space") until January 31, 2025, with an extension option through September 11, 2026. The monthly lease payment for the Lab Space will be $48,475.85 commencing on December 1, 2021, with an annual rent escalation of approximately 3% commencing on December 1, 2022. The Sixth Amendment includes a Landlord's contribution for certain leasehold improvements for the Lab Space in an amount of up to $89,265.00.

The foregoing description of the Sixth Amendment does not purport to be complete and is qualified in its entirety by reference to the Sixth Amendment, a copy of which the Company expects to file as an exhibit to its Annual Report on Form 10-K for the fiscal year ending December 31, 2020.

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