The following discussion should be read in conjunction with our consolidated
financial statements and notes thereto under "Item 15. Exhibits and financial
statement schedules" in this annual report on Form 10-K. Forward-looking
statements involve inherent risks and uncertainties regarding events,
conditions, and financial trends that may affect our future plans of operations,
business strategy, results of operations, and financial position. A number of
important factors could cause actual results to differ materially from those
included within or contemplated by such forward-looking statements, including,
but not limited to, those described within this "Item 7. Management's discussion
and analysis of financial condition and results of operations" in this annual
report on Form 10-K. We do not undertake any responsibility to update any of
these factors or to announce publicly any revisions to any of the
forward-looking statements contained in this or any other document, whether as a
result of new information, future events, or otherwise.

As used in this annual report on Form 10-K, references to the "Company," "Alexandria," "ARE," "we," "us," and "our" refer to Alexandria Real Estate Equities, Inc. and its consolidated subsidiaries.


                                       85
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g32.jpg]]
                                       86
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g33.jpg]]

Refer to the definition of "Annual rental revenue" in the "Non-GAAP measures and definitions" section within this Item 7 for additional details.


                                       87
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g34.jpg]]
                                       88
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g35.jpg]]
(1)Represents total equity capitalization for publicly traded U.S. REITs, from
Bloomberg Professional Services as of December 31, 2021. Alexandria's total
equity capitalization is calculated using shares outstanding and the closing
stock price as of December 31, 2021.
                                       89
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g36.jpg]]
                                       90
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g37.jpg]]
                                       91
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g38.jpg]]
                                       92
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g39.jpg]]
                                       93
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g40.jpg]]
                                       94
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g41.jpg]]
                                       95
--------------------------------------------------------------------------------



                    [[Image Removed: are-20211231_g42.jpg]]
As of December 31, 2021.
(1)We also expect other projects to commence construction in 2022.
                                       96
--------------------------------------------------------------------------------


Executive summary

Operating results
                                                                       Year Ended December 31,
                                                                      2021                   2020
Net income attributable to Alexandria's common
stockholders - diluted:
In millions                                                     $        563.4          $     760.8
Per share                                                       $         3.82          $      6.01
Funds from operations attributable to Alexandria's common stockholders - diluted,
as adjusted:
In millions                                                     $      1,144.9          $     923.8
Per share                                                       $         7.76          $      7.30



The operating results shown above include certain items related to
corporate-level investing and financing decisions. For additional information,
refer to "Funds from operations and funds from operations, as adjusted,
attributable to Alexandria Real Estate Equities, Inc.'s common stockholders" in
the "Non-GAAP measures and definitions" section and to the tabular presentation
of these items in the "Results of operations" section within this Item 7 in this
annual report on Form 10-K.

Historic leasing volume and rental rate growth

•Historic demand for our high-quality office/laboratory space has translated into record leasing volume and rental rate growth in 2021 for our overall portfolio and our value-creation pipeline.


                                                                               2021                Previous Annual Record
Total leasing activity - RSF                                                  9,516,301    (1)           5,062,722
Leasing of development and redevelopment space - RSF                          3,867,383    (1)           2,258,262
Lease renewals and re-leasing of space:
RSF (included in total leasing activity above)                                4,614,040    (1)           2,562,178
Rental rate increases                                                                37.9% (1)                         37.6%
Rental rate increases (cash basis)                                                   22.6% (1)                         18.3%


(1)Represents the highest leasing volume and rental rate growth in Company history.

Continued strong net operating income and internal growth



•Total revenues of $2.1 billion, up 12.1%, for the year ended December 31, 2021,
compared to $1.9 billion for the year ended December 31, 2020.
•Net operating income (cash basis) of $1.3 billion for the year ended
December 31, 2021, increased by $119.2 million, or 9.9%, compared to the year
ended December 31, 2020.
•95% of our leases contain contractual annual rent escalations approximating 3%.
•Same property net operating income growth of 4.2% and 7.1% (cash basis) for the
year ended December 31, 2021, compared to the year ended December 31, 2020.

A REIT industry-leading high-quality tenant roster with high-quality revenues
and cash flows, strong margins, and operational excellence; growth of 100 bps in
occupancy over December 31, 2020(1)
Percentage of total annual rental revenue in effect from
investment-grade or publicly traded large cap tenants                                        51  %

Occupancy of operating properties in North America                                           94  %

Occupancy of operating properties in North America (excluding vacancy at


                       (1)
recently acquired properties)                                                              98.7  %
Operating margin                                                                             70  % (2)
Adjusted EBITDA margin                                                                       71  % (2)
Weighted-average remaining lease term:
All tenants                                                                                    7.5 years
Top 20 tenants                                                                                10.9 years


(1)Excludes 1.8 million RSF, or 4.7%, of vacancy at recently acquired properties
representing lease-up opportunities that are expected to provide incremental
annual rental revenues. Excluding recently acquired vacancies, occupancy was
98.7% as of December 31, 2021, up 100 bps from 97.7% as of December 31, 2020.
Refer to the "Summary of occupancy percentages in North America" section under
Item 2 in this annual report on Form 10-K for additional information regarding
vacancy from recently acquired properties.
(2)For the three months ended December 31, 2021.
                                       97
--------------------------------------------------------------------------------

Historic high demand drives visibility for future growth aggregating $610 million of incremental annual rental revenue from 7.4 million RSF of value-creation projects that are 83% leased/negotiating



Our highly leased value-creation pipeline of current and near-term projects that
are under construction or that will commence construction in the next six
quarters is expected to generate greater than $610 million of incremental annual
rental revenues, primarily commencing from the first quarter of 2022 through the
fourth quarter of 2024.
•7.4 million RSF of our value-creation projects are either under construction or
expected to commence construction in the next six quarters.
•83% leased/negotiating.

Continued dividend strategy to share growth in cash flows with stockholders



Common stock dividend declared for the three months ended December 31, 2021 of
$1.15 per common share, aggregating $4.48 per common share for the year ended
December 31, 2021, up 24 cents, or 6%, over the year ended December 31, 2020.
Our FFO payout ratio of 60% for the three months ended December 31, 2021 allows
us to continue to share growth in cash flows from operating activities with our
stockholders while also retaining a significant portion for reinvestment.

Alexandria at the vanguard of innovation for over 850 tenants, with a focus on accommodating current tenant needs and providing a path for their future growth



•During 2021, we completed acquisitions in our key life science cluster
submarkets aggregating 18.4 million SF, comprising 15.2 million RSF of
value-creation opportunities and 3.2 million RSF of operating space, for an
aggregate purchase price of $5.5 billion, including our previously announced
acquisition of One Rogers Street in our Cambridge submarket for a purchase price
of $849.4 million. These acquisitions are primarily focused on future
development or redevelopment opportunities to expand our mega campuses and
accommodate the future growth of our tenants.

Delivery and commencement of value-creation projects



•Since the beginning of 2021, we placed into service development and
redevelopment projects aggregating 2.0 million RSF that are 100% leased across
multiple submarkets.
•Annual net operating income (cash basis) is expected to increase by $39 million
upon the burn-off of initial free rent from recently delivered projects.
•We commenced development and redevelopment projects aggregating 3.4 million RSF
during the year ended December 31, 2021.
•During the three months ended December 31, 2021, we commenced construction on
four value-creation projects aggregating 1.1 million RSF , including a 403,892
RSF recently acquired redevelopment project at One Rogers Street, which expands
our Alexandria Center® at Kendall Square mega campus in Cambridge. We pre-leased
the entire building by executing leases aggregating 403,892 RSF prior to the
closing of the acquisition in December 2021.
•In January 2022, we completed the acquisition of 202,997 SF additional
development entitlements, for an aggregate of 507,997 SF, at our 421 Park Drive
future development site in our Alexandria Center® for Life Science - Fenway mega
campus in our Fenway submarket.

Alexandria's disciplined management of our value-creation pipeline

Value-creation pipeline of new Class A development and redevelopment projects as a percentage of gross assets

December 31, 2021
Under construction projects 82% leased/negotiating                                              9%
Pre-leased/negotiating near-term projects 89% leased/negotiating                                2%
Income-producing/potential cash flows/covered land play(1)                                      6%
Land                                                                                            2%


(1)Includes projects that have existing buildings that are generating or can
generate operating cash flows. Also includes development rights associated with
existing operating campuses.


                                       98

--------------------------------------------------------------------------------

Execution of capital strategy

2021 capital strategy

During 2021, we continued to execute on many of the long-term components of our capital strategy, as described below.

Maintained access to diverse sources of capital strategically important to our long-term capital structure

•Generated significant cash flows from operating activities In 2021, we funded approximately $230 million of our equity capital needs with cash flows from operating activities.



•Continued strategic value harvesting through real estate dispositions and
partial interest sales
In 2021, these sales generated a record $2.6 billion of capital for investment
into our highly leased development and redevelopment projects and strategic
acquisitions. In relation to these transactions, we recorded gains or
consideration in excess of book value aggregating $1.1 billion.

•Achieved significant growth in Adjusted EBITDA of $299.6 million, or 23%,
during 2021, which allowed us to:
•Improve our net debt to Adjusted EBITDA (fourth quarter of 2021 annualized)
ratio to 5.2x from 5.3x, the lowest in 10 years, and fund $1.6 billion of growth
on a leverage-neutral basis.
•Take advantage of favorable capital market environment and opportunistically
issue on a leverage-neutral basis unsecured senior notes payable aggregating
$1.75 billion with a weighted-average interest rate of 2.49% and a
weighted-average maturity of 20.4 years, a portion of the proceeds from which
was used to refinance our 4.00% unsecured senior notes payable due in 2024.

•Continued disciplined management of common equity issuances to support growth
in FFO per share, as adjusted, and NAV
In 2021, the aforementioned internally generated capital enabled us to meet our
capital requirements while prudently limiting the amount of equity issuances to
20.8 million shares of common stock sold under our forward equity sales
agreements and ATM common stock offering program for net proceeds of $3.5
billion.

Maintained a strong and flexible balance sheet with significant liquidity



•$3.8 billion liquidity as of December 31, 2021.
•Net debt and preferred stock to Adjusted EBITDA of 5.2x and fixed-charge
coverage ratio of 5.3x for the three months ended December 31, 2021, annualized,
representing the best ratios in the past 10 years.
•Total debt and preferred stock to gross assets of 26% as of December 31, 2021.
•Weighted-average remaining term of debt of 12.1 years as of December 31, 2021,
with no debt maturing prior to 2024.
•Total equity capitalization of $35.2 billion is in the top 10% among all
publicly traded U.S. REITs as of December 31, 2021.

Continued to strengthen our credit profile



•In October 2021, S&P Global Ratings upgraded our corporate issuer credit rating
outlook to BBB+/Positive from BBB+/Stable.
•As of December 31, 2021, our investment-grade credit ratings ranked in the top
10% among all publicly traded U.S. REITs.

2022 capital strategy



During 2022, we intend to continue to execute our capital strategy to achieve
further improvements to our credit profile, which will allow us to further
improve our cost of capital and continue our disciplined approach to capital
allocation. Consistent with 2021, our capital strategy for 2022 includes the
following elements:

•Allocate capital to Class A properties located in life science, agtech, and
tech campuses in AAA urban innovation clusters;
•Maintain prudent access to diverse sources of capital, which include cash flows
from operating activities after dividends, incremental leverage-neutral debt
supported by growth in EBITDA, strategic value harvesting and asset recycling
through real estate disposition and partial interest sales, non-real estate
investment sales, sales of equity, and other capital;
•Continue to improve our credit profile;
•Maintain commitment to long-term capital to fund growth;
•Prudently ladder debt maturities and manage short-term variable-rate debt;
•Prudently manage equity investments to support corporate-level investment
strategies;
•Maintain a stable and flexible balance sheet with significant liquidity.

The anticipated delivery of significant incremental EBITDA from our development
and redevelopment of new Class A properties is expected to enable us to continue
to debt fund a significant portion of our development and redevelopment projects
on a leverage-neutral basis. We expect to continue to maintain access to diverse
sources of capital, including unsecured senior notes payable, and secured
construction loans for our development and redevelopment projects from time to
time. We expect to continue to maintain a significant proportion of our net
operating income on an unencumbered basis to allow for future flexibility for
accessing both unsecured and secured debt markets, although we expect
traditional secured mortgage notes payable will remain a small component of our
capital structure. We intend to supplement our remaining capital needs with net
cash flows from operating activities after dividends and proceeds from real
estate asset sales, non-real estate investment sales, partial interest sales,
and equity capital. For further information, refer to the "Projected results",
"Sources of Capital," and "Uses of Capital" sections under this Item 7. Our
ability to meet our 2022 capital strategy objectives and expectations will
depend in part on capital market conditions, real estate market conditions, and
other factors beyond our control. Accordingly, there can be no assurance that we
will be able to achieve these objectives and expectations. Refer to our
discussion of "Forward-looking statements" in this annual report on Form 10-K.
                                       99
--------------------------------------------------------------------------------


Operating summary

                                     Same Property Net Operating
                                            Income Growth                                                                                             Favorable Lease Structure(1)
                                                                                                              Strategic Lease Structure by Owner and

Operator of Collaborative Life Science, Agtech, and Technology


                                                                                                                                                            Campuses
                                                                                                              Increasing cash flows
                                                                                                              Percentage of leases containing annual rent escalations                                   95%

       [[Image Removed: are-20211231_g43.jpg]]            [[Image Removed:

are-20211231_g44.jpg]]             Stable cash flows
                                                                                                              Percentage of triple                                                                      91%         (2)
                                                                                                              net leases
                                                                                                              Lower capex burden
                                                                                                              Percentage of leases providing for the recapture of capital expenditures                  94%


                                         Rental Rate Growth:
                                       Renewed/Re-Leased Space                                                                                                 Margins(3)

                                                                                                                              Operating                                                   Adjusted EBITDA
       [[Image Removed: are-20211231_g45.jpg]]            [[Image Removed:

are-20211231_g46.jpg]]                                70%                                                            71%




                                     Net Debt and Preferred Stock
                                        to Adjusted EBITDA(4)                                                                                       

Fixed-Charge Coverage Ratio(4)



                               [[Image Removed: are-20211231_g47.jpg]]                                                                          [[Image 

Removed: are-20211231_g48.jpg]]






(1)Percentages calculated based on RSF as of December 31, 2021.
(2)Decline to 91% from 94% as of December 31, 2020 is primarily related to
non-triple net leases in place at operating properties with future development
or redevelopment opportunities acquired during the year ended December 31, 2021.
We expect to transition these properties to our triple net lease structure in
conjunction with our future development or redevelopment activities.
(3)Represents percentages for the three months ended December 31, 2021.
(4)Quarter annualized. Refer to the definitions of "Net debt and preferred stock
to Adjusted EBITDA" and "Fixed-charge coverage ratio" in the "Non-GAAP measures
and definitions" section within this Item 7 for additional details.
                                      100
--------------------------------------------------------------------------------

Industry and ESG leadership: catalyzing and leading the way for positive change to benefit human health and society



•In January 2021, Alexandria Venture Investments, our strategic venture capital
platform, was recognized for a fourth consecutive year as the most active
biopharma corporate investor by new deal volume by Silicon Valley Bank in its
"Healthcare Investments and Exits: Annual Report 2021." In February 2021,
Alexandria Venture Investments was also recognized as one of the five most
active U.S. investors in agrifoodtech by deal volume in 2020 by AgFunder in its
"2021 AgFunder AgriFoodTech Investment Report."
•In February 2021, Alexandria was ranked as the third most sustainable REIT, as
featured in Barron's "The 10 Most Sustainable REITs, According to Calvert."
•In March 2021, Alexandria LaunchLabs® at the Alexandria Center® at One Kendall
Square in our Cambridge submarket was awarded the Fitwel Impact Award for
achieving the highest-scoring project of all time. This is the second year in a
row that Alexandria has held this distinction, demonstrating our commitment to
optimizing projects to advance health and wellness.
•In May 2021, Alexandria was ranked in the top 10 of the world's largest and
most impactful real estate firms on the Forbes 2021 Global 2000 list determined
based on sales, profits, assets, and market value.
•In June 2021, we released our 2020 Environmental, Social & Governance Report,
which showcases our longstanding ESG commitment and leadership. Key highlights
in the report include the company's critical efforts to tackle climate change by
pioneering low-carbon and climate-resilient design solutions, mitigating
climate-related risk in our asset base, and investing in and providing essential
infrastructure for sustainable agrifoodtech companies; continuing strong
progress toward our 2025 environmental impact goals, including further reducing
carbon emissions; and catalyzing the health, wellness, safety, and productivity
of our employees and tenants, local communities, and the world at large through
the built environment and our social responsibility initiatives.
•In September 2021, OneFifteen, an innovative, data-driven non-profit
evidence-based healthcare ecosystem dedicated to the full and sustained recovery
of people living with addiction, received an honorable mention in Fast Company's
2021 Innovation by Design Awards in the Impact category. Alexandria led the
design and development of the pioneering campus in Dayton, Ohio, which houses a
unique, evidence-based model encompassing a full continuum of care in one
location, from intake, medication-assisted treatment, and residential living to
family reunification, job training, and community transition.
•In September 2021, the National September 11 Memorial & Museum honored Joel S.
Marcus, our executive chairman and founder, for Distinction in Civic Engagement
and Renewal, recognizing his meaningful contributions to and unwavering support
of the 9/11 Memorial & Museum and its mission. As an active supporter of the
Memorial & Museum since it opened in 2014, Mr. Marcus has served as a member of
its board of trustees since his appointment in 2018 by former New York City
Mayor Michael Bloomberg.
•In September 2021, Alexandria achieved the Fitwel Viral Response Certification
With Distinction, the highest certification level within the Fitwel Viral
Response module, for the second consecutive year. This evidence-based,
third-party certification recognizes the Company's comprehensive and rigorous
approach to protecting the health of its building occupants.
•In October 2021, Alexandria received an ESG Rating of A from MSCI as a result
of our continued advancement of green building opportunities, recognition of
talent management programs, and below-industry-average turnover rate, among
other achievements. Our MSCI ESG Rating of A is in the top 10% among all
publicly traded U.S. equity REITs.
•In October 2021, our ESG commitment and leadership was recognized in the 2021
Global Real Estate Sustainability Benchmark ("GRESB") Real Estate Assessment,
including for the following achievements: (i) Global Sector Leader and a 5 Star
rating - GRESB's highest rating - in the Diversified Listed sector for buildings
in development, (ii) #2 ranking in the U.S. in the Science & Technology sector
for buildings in operation, and (iii) fourth consecutive "A" disclosure score.
•In October 2021, OneFifteen celebrated its second anniversary. Since seeing its
first patients in October 2019 at its pioneering campus in Dayton, Ohio, which
was designed and developed by Alexandria, OneFifteen has treated over 4,000
patients and conducted over 11,500 telehealth visits as of December 31, 2021.
•In October 2021, STEAM:Coders honored Alexandria with the Corporate Vanguard
Award, recognizing our longstanding commitment to the non-profit's mission to
inspire underrepresented and underserved students and their families through
science, technology, engineering, art, and math ("STEAM") education in
preparation for academic and career opportunities.
•As a testament to Alexandria's operational excellence and exceptional team, in
November 2021, we were recognized at the 2021 BOMA Boston TOBY (The Outstanding
Building of the Year) & Industry Awards for the Laboratory Building of the Year
(100 Binney Street) and the Corporate Facility of the Year (200 Technology
Square). Five members from our Greater Boston team were also honored for their
individual achievements. The TOBY & Industry Awards recognize excellence in
property management, building operations, and service in the commercial real
estate industry.
•In November 2021, Alexandria's executive chairman and founder, Joel S. Marcus,
joined the National Medal of Honor Museum Foundation at the Dallas Cowboys'
"Salute to Service" game to support the future National Medal of Honor Museum in
Arlington, Texas and its mission to inspire visitors with the stories of our
country's Medal of Honor recipients for generations to come. Mr. Marcus has
served on the foundation's board of directors since 2019.
•In December 2021, Alexandria established a new social responsibility pillar to
address America's growing mental health crisis, with a focus on helping children
cope with the loss of a parent or family member to suicide. By partnering with
Camp Kita, a tuition-free summer camp for 8- to 17-year-olds who are impacted by
the loss of a family member to suicide, we have enabled the non-profit to have
long-term access to 28 acres in Acton, Maine that will serve as the camp's
future home. The dedicated space will allow Camp Kita to expand its programming,
advance its mission, and support the mental health of a community of young
survivors.

                                      101
--------------------------------------------------------------------------------

                    [[Image Removed: are-20211231_g49.jpg]]
                                      102
--------------------------------------------------------------------------------

Climate Change and Sustainability



We cannot predict the rate at which climate change will progress. However, the
physical effects of climate change could have a material adverse effect on our
properties, operations, and business. For example, most of our properties are
located along the east and west coasts of the U.S. and some of our properties
are located in close proximity to shorelines. To the extent that climate change
impacts weather patterns, our markets could experience severe weather, including
hurricanes, severe winter storms, wild fires, droughts, and coastal flooding due
to increases in storm intensity and rising sea levels. Over time, these
conditions could result in declining demand for space at our properties, delays
in construction and resulting increased construction costs, or in our inability
to operate the buildings at all. Climate change and severe weather may also have
indirect effects on our business by increasing the cost of, or decreasing the
availability of, property insurance on terms we find acceptable, and by
increasing the costs of energy, maintenance, repair of water and/or wind damage,
and snow removal at our properties. We continue to evaluate our asset base for
potential exposure to the following climate-related risks: sea level rise and
increases in heavy rain, flood, drought, extreme heat, and wildfire. As a part
of Alexandria's risk management program, we purchase property insurance to
mitigate the risk of extreme weather events and natural disasters. However, our
insurance may not adequately cover all of our potential losses. As a result,
there can be no assurance that climate change and severe weather will not have a
material adverse effect on our properties, operations, or business.

Board of Directors and Leadership Oversight



The Audit Committee of Alexandria's Board of Directors oversees the management
of the company's financial and other systemic risks, including those related to
climate. At a management level, Alexandria's Sustainability Committee, which
comprises members of the executive team and senior decision makers spanning the
company's Real Estate Development, Asset Management, Risk, and Sustainability
teams, leads the development and execution of our approach to climate-related
risk.

Proactively Managing and Mitigating Climate Risk



The resilience of our properties under a changing climate is paramount both for
our business and our tenants' mission-critical research, development,
manufacturing, and commercialization efforts. We consider the potential impacts
associated with climate change and extreme weather conditions in the
acquisition, design, development, and operation of our buildings and campuses.
We align our climate change management efforts with the guidelines issued by the
Task Force on Climate-related Financial Disclosures ("TCFD"), which we endorsed
in 2018. Our industry-leading environmental initiatives, programs, and policies
and our proactive approach to the identification and management of evolving
physical conditions and transition issues continue to raise the bar in the
industry for mitigating greenhouse gas ("GHG") emissions and bolstering climate
resilience.

As further detailed in the "Monitoring and Preparing for Transition" subsection
below, over the past few years, regulatory bodies in most of our regions have
either passed or proposed legislation to limit the carbon footprint of
buildings, require procurement of clean power, or eliminate natural gas from new
construction projects. Additionally, certain U.S. jurisdictions incorporated
guidelines into their building codes to address the up-front impacts of building
materials such as concrete. Moreover, our tenant preferences for green,
efficient, and healthy buildings continue to rise. As of December 31, 2021, 80%
of Alexandria's top 20 tenants (by annual rental revenue) have set net-zero
carbon and/or carbon neutrality goals, compared to 50% of our top 20 tenants as
of December 31, 2020. As a result of our own sustainability mission compelling
us to reduce carbon emissions and mitigate climate risk, as well as the changing
regulatory environment and our tenants' expectations, we have implemented a
comprehensive approach to assessing and mitigating physical risk to our
properties as well as to preparing for the transition, as described below.

Assessing and Mitigating Physical Risk to Our Properties



In accordance with TCFD methodology, we consider a range of scenarios for 2030
and 2050 when evaluating physical risk to our properties: (1) a
business-as-usual scenario in which GHG emissions continue to increase with time
(Representative Concentration Pathways ("RCP") 8.5); and (2) a mitigation
scenario in which GHG emissions level off by 2050 and decline thereafter (RCP
4.5). To ensure a conservative evaluation of potential risk at the asset level,
we use the RCP 8.5 scenario, which has greater climate hazard impacts than RCP
4.5. These climate change assessments covering both acute and chronic risks
enable us to assess preparedness for climate-related risks across the real
estate life cycle.

For our property acquisitions, our risk management and sustainability teams conduct climate change evaluations and advise the transactions and property teams of any need for potential property upgrades, which are evaluated in our financial modeling and transactional decisions.



For our developments and redevelopments of new Class A properties, we evaluate
the potential impact of sea level rise, storm surges in coastal or tidal
locations, and changing temperatures out to the year 2050. As feasible, we
design for the potential need to add cooling infrastructure to meet future
building needs while maintaining flexibility and optimizing infrastructure funds
for more immediate needs. In water-scarce areas, we aim to plant
drought-resistant vegetation and prepare buildings to connect to a municipal
recycled-water infrastructure where available and feasible. In areas prone to
wildfire, we incorporate brush management practices into landscape design and
may also include enhanced air filtration systems to support safe, healthy indoor
air under extreme air pollution conditions.
                                      103
--------------------------------------------------------------------------------

At our buildings in operation, we evaluate to what extent we have mitigations in
place and which operational and physical improvements can be made where
potential concerns have been identified. For example, resilience measures
implemented at some of our properties include the following: in areas prone to
floods we position critical building mechanical equipment on the roofs or
significantly above the projected potential flood elevations; we purchase
temporary flood barriers that we store on-site and can deploy at building
entrances prior to a flood event; we elevate property entrances or the first
floor above projected present day and future flood elevations; we install
backflow preventors on storm/sewer utilities that discharge from the building;
and we waterproof the building envelope up to the projected flood elevation. In
areas prone to fire, and to the extent feasible, we locate our properties away
from large fire hazards, such as large grassy or brush areas; our landscaping
vegetation consists of less flammable vegetation species that are positioned in
a reasonable distance from a property; our building envelopes are constructed
with fire-resistant materials and are sealed; and in the event of fire, our HVAC
systems are able to filtrate smoke particulates in the air.

COMPREHENSIVE APPROACH TO ASSESSING & MITIGATING PHYSICAL RISK
Acquisitions
•Conduct climate change assessment.
•Incorporate potential mitigation strategies, where applicable, into financial modeling
and transactional decisions.
Developments and Redevelopments
•Review climate change assessment.
•Assess potential risks and account for 2050 climate projections and an RCP 8.5 scenario.
•Consider physical and operational measures in design to increase the property's
resilience.
•Identify operational mitigation measures and ongoing monitoring opportunities.
Buildings in Operation
•For new and redeveloped assets transitioning into operations:
•Consider implementation and prioritization of operational mitigation measures and ongoing
monitoring.
•For existing assets:
•Review climate change assessment.
•Where potential risks have been identified, assess to what extent mitigation measures are
in place and which operational and physical improvements can be made to increase the
property's resilience.
•Develop an implementation plan.



Monitoring and Preparing for Transition



Globally, public concern regarding climate change has been growing rapidly. To
join efforts and to accelerate action to reduce GHG emissions, on November 13,
2021, nearly 200 countries attended the United Nations' annual climate summit,
COP26, and adopted the Glasgow Climate Pact (the "Pact"), which includes terms
to strengthen efforts to address climate change by building resilience, reducing
GHG emissions, providing additional funding from developed to developing
countries, and limiting global temperature increase to 1.5 Celsius above
pre-industrial levels. The Pact for the first time includes language that calls
upon countries to reduce their reliance on coal power and roll back inefficient
fossil fuel subsidies. A number of other notable agreements were made during the
COP26 summit, including, among others, an agreement between the U.S. and the EU
to spearhead an initiative to reduce methane emissions by 30% by 2030. It is
unknown how or if the Pact's measures will be carried out effectively or whether
these measures will be sufficient to mitigate the effects of climate change over
time.

In August 2021, the United Nations' Intergovernmental Panel on Climate Change
issued a detailed report titled "Climate Change 2021: The Physical Science
Basis" that provides a comprehensive evidence of the catastrophic impact of GHG
emissions on climate change, including increases in severe and dangerous weather
conditions. According to the latest data provided by the U.S. Environmental
Protection Agency ("U.S. EPA"), the U.S. is responsible for approximately 15% of
the global GHG emissions. To combat the cause of global warming domestically,
President Biden identified climate change as one of his top priorities and
pledged to seek measures that would pave the path for the U.S. to eliminate net
GHG pollution by 2050. In April 2021, President Biden announced his plan to
reduce the U.S. GHG emissions by at least 50% by 2030. These environmental goals
earned a prominent place in President Biden's $1.2 trillion infrastructure bill,
which was signed into law on November 15, 2021. It is not yet known what impact
this law may have on our properties, business operations, or our tenants.

                                      104
--------------------------------------------------------------------------------

Numerous states and municipalities have adopted laws and policies on climate change and emission reduction targets, including, but not limited to, the following:



•In California, State Governor Gavin Newsom signed legislation in September 2021
aimed at achieving net-zero GHG emissions associated with cement used within the
state no later than 2045. In November 2020, the San Francisco Board of
Supervisors adopted an All-Electric New Construction Ordinance that will require
all new buildings (residential and non-residential) with initial building permit
applications made on or after June 1, 2021 to have all-electric indoor and
outdoor space-conditioning, water heating, cooking, and clothes drying systems.
In addition, in September 2020, Mr. Newsom signed an executive order requiring
all new passenger cars and trucks sold in the state to be emission free by 2035.
Also in September 2018, Senate Bill 100 was signed into law in California,
accelerating the state's renewable portfolio standard target dates and setting a
policy of meeting 100% of retail electricity sales from eligible renewables and
zero-carbon resources by December 31, 2045.

•In Massachusetts, Senate Bill 9 was signed into law in March 2021, updating the
state's climate policy to ensure net-zero GHG emissions by 2050 and establishing
interim emission reduction targets for several sectors, including commercial and
industrial buildings.

•In New York, the Climate Leadership and Community Protection Act was signed
into law in July 2019, establishing a statewide framework to reduce net GHG
emissions to no less than 85% below 1990 levels by 2050. Also, in May 2019, New
York City enacted Local Law 97 as a part of the Climate Mobilization Act aimed
at reducing GHG emissions by 80% from commercial and residential buildings by
2050. Starting in 2024, this law will place carbon caps on most buildings larger
than 25,000 square feet. In addition, in December 2021, New York City passed
Local Law 154 of 2021, which will phase out fossil fuel usage in newly
constructed residential and commercial buildings starting in 2024 for lower-rise
buildings, and in 2027 for taller buildings. With few exceptions, all buildings
constructed in New York City must be fully electric by 2027.

•In Washington, the State Legislature has passed a number of bills since 2019
focused on phasing out fossil fuels, achieving carbon neutrality, reducing GHG
emissions, supporting the sale of zero-emissions vehicles, and establishing
clean fuel standards. In support of these efforts, in 2020, Washington updated
its GHG emission goals to require a reduction of 45% below 1990 levels by 2030,
of 70% below 1990 levels by 2040, and net-zero emissions by 2050.

•In North Carolina, State Governor Roy Cooper signed an executive order in
January 2022 that updates the state's GHG emission goals to require a reduction
of 50% below 2005 levels by 2030, and achievement of net-zero emissions by 2050.

Alexandria has implemented a comprehensive approach to responding to transition risk through the following strategies:

Decarbonizing construction



Alexandria targets LEED Gold or Platinum certification for new ground-up
developments. Through our sustainability goals for new developments, we deliver
energy- and resource-efficient buildings that meet or exceed tenant, city, and
state requirements for energy and water efficiency, material sourcing,
biodiversity, and alternative transportation.

We are also revolutionizing the design of our buildings through innovative
low-carbon solutions. At 325 Binney Street, on our Alexandria Center at One
Kendall Square mega campus in Cambridge, the building design is expected to
yield a 95% reduction in fossil fuel consumption. The project is targeting LEED
Platinum Core & Shell and LEED Zero Energy certifications. At 685 Gateway
Boulevard in South San Francisco, we are targeting Zero Energy Certification
through the International Living Future Institute (ILFI) by leveraging design
strategies such as building envelope optimization, high-performance features,
and on-site energy generation.

With several jurisdictions shifting (or with plans to shift soon) from fossil
fuels for heating and requiring all electric buildings as a strategy to reduce
carbon emissions associated with building operations, we have proactively
incorporated electrification into building designs, with one project completed
and two currently in progress.

Embodied carbon in building materials and construction accounts for 11% of
annual global GHG emissions and Alexandria is playing a leadership role in the
industry's effort to measure and ultimately reduce carbon associated with the
construction process. In 2019, Alexandria became a sponsor and the first REIT to
use the Carbon Leadership Forum's Embodied Carbon in Construction Calculator
(EC3) tool. For new construction projects, Alexandria seeks to procure products
with Environmental Product Declarations (EPDs), which provide information on
product composition and environmental impact. Using such EPDs, Alexandria aims
to reduce embodied carbon by 10% for new ground-up development projects. As of
December 31, 2021, Alexandria has completed three embodied carbon assessments
and others are in progress for 15 development projects.

                                      105
--------------------------------------------------------------------------------

Leveraging renewable energy



We are pursuing opportunities to power our buildings with renewable energy as
another means to reduce our carbon footprint. Properties such as 3215 Merryfield
Row in San Diego are generating solar energy, and our development pipeline will
scale our ability to source additional clean energy on-site. We also procure
renewable energy generated off-site from local utilities and from power service
providers for some of our operating assets.

Reducing the environmental footprint of buildings in operation



Our sustainability mission compels us toward industry-leading sustainability
practices and performance that can help reduce operating expenses and result in
higher occupancy levels, longer lease terms, higher rental income, higher
returns, and greater long-term asset value, and thus enable us to capture
climate-related opportunities. Our ongoing efforts to reduce consumption are
driven by our commitment to operational excellence in sustainability, building
efficiency, and service to our tenants. Alexandria's 2025 sustainability goals
for buildings in operation and new ground-up construction projects provide the
framework, metrics, and targets that guide the Company's focus on continuous,
long-term improvement. For buildings in operation, we set goals to reduce carbon
emissions, energy consumption, and potable water consumption and increase waste
diversion by 2025. From 2019 to 2020, we reduced energy use by 1.7%, carbon
emissions by 1.7%, and water use by 6.9% and achieved a 38.5% waste diversion
rate in 2020 alone.

                    [[Image Removed: are-20211231_g50.jpg]]
(1)Relative to a 2015 baseline for buildings in operation that Alexandria
directly manages.
(2)For buildings in operation that Alexandria indirectly and directly manages.
(3)Reflects sum of annual like-for-like progress from 2015 to 2020.
(4)Reflects progress for all buildings in operation in 2020 that Alexandria
indirectly and directly manages.


As we look to the future, we are creating our long-term strategy and plan for
the net zero-carbon transition. We are developing an approach to set
industry-leading science-based targets that will provide a pathway to reduce
scope 1, 2, and 3 GHG emissions and continue our leadership in sustainability.

Refer to "Item 1A. Risk factors" of this annual report on Form 10-K for discussion of the risks posed by climate change.


                                      106
--------------------------------------------------------------------------------

                    [[Image Removed: are-20211231_g51.jpg]]
                                      107
--------------------------------------------------------------------------------

                    [[Image Removed: are-20211231_g52.jpg]]
                                      108
--------------------------------------------------------------------------------

                    [[Image Removed: are-20211231_g53.jpg]]

(1)Source: Barron's, "The 10 Most Sustainable REITs, According to Calvert," February 19, 2021.


                                      109
--------------------------------------------------------------------------------

Results of operations



We present a tabular comparison of items, whether gain or loss, that may
facilitate a high-level understanding of our results and provide context for the
disclosures included in this annual report on Form 10-K. We believe such tabular
presentation promotes a better understanding for investors of the
corporate-level decisions made and activities performed that significantly
affect comparison of our operating results from period to period. We also
believe this tabular presentation will supplement for investors an understanding
of our disclosures and real estate operating results. Gains or losses on sales
of real estate and impairments of held for sale assets are related to
corporate-level decisions to dispose of real estate. Gains or losses on early
extinguishment of debt, gains or losses on early termination of interest rate
hedge agreements, and preferred stock redemption charges are related to
corporate-level financing decisions focused on our capital structure strategy.
Significant realized and unrealized gains or losses on non-real estate
investments, impairments of real estate and non-real estate investments, and
significant termination fees are not related to the operating performance of our
real estate assets as they result from strategic corporate-level decisions and
external market conditions. Impairments of non-real estate investments are not
related to the operating performance of our real estate as they represent the
write-down of non-real estate investments when their fair values decline below
their respective carrying values due to changes in general market or other
conditions outside of our control. Significant items included in the tabular
disclosure for current periods are described in further detail under this Item 7
in this annual report on Form 10-K. Items included in net income attributable to
Alexandria's common stockholders were as follows:
                                                                         

Year Ended December 31,


                                                        2021             2020              2021              2020
(In millions, except per share amounts)                        Amount                       Per Share - Diluted
Unrealized gains on non-real estate investments      $  43.6          $ 374.0          $     0.30          $ 2.96
Significant realized gains on non-real estate
investments                                            110.1                -                0.75               -
Gain on sales of real estate(1)                        126.6            154.1                0.86            1.22
Impairment of real estate                              (52.7)           (55.7)              (0.35)          (0.44)
Impairment of non-real estate investments                  -            (24.5)                  -           (0.19)
Loss on early extinguishment of debt                   (67.3)           (60.7)              (0.46)          (0.48)
Termination fee                                            -             86.2                   -            0.68
Acceleration of stock compensation expense due to
executive officer resignation                              -             (4.5)                  -           (0.04)
Total                                                $ 160.3          $ 468.9          $     1.10          $ 3.71

(1)Refer to "Funds from operations and funds from operations, as adjusted, attributable to Alexandria Real Estate Equities, Inc.'s common stockholders" in the "Non-GAAP measures and definitions" section within this Item 7 for additional information.


                                      110
--------------------------------------------------------------------------------

Same properties



We supplement an evaluation of our results of operations with an evaluation of
operating performance of certain of our properties, referred to as "Same
Properties." For additional information on the determination of our Same
Properties portfolio, refer to the definition of "Same property comparisons" in
the "Non-GAAP measures and definitions" section under this Item 7 in this annual
report on Form 10-K. The following table presents information regarding our Same
Properties as of December 31, 2021 and 2020:
                                                                                        December 31,
                                                                               2021                       2020

Percentage change in net operating income over comparable period from prior year

                                                                  4.2%                    2.6  %

Percentage change in net operating income (cash basis) over comparable period from prior year


            7.1%                    5.1  %
Operating margin                                                                         72%                       73%
Number of Same Properties                                                             247                          209
RSF                                                                               23,490,412                20,707,818
Occupancy - current-period average                                                     96.6%                   96.6  %
Occupancy - same-period prior-year average                                             96.3%                   96.7  %



The following table reconciles the number of Same Properties to total properties for the year ended December 31, 2021:



Development - under construction                                  Properties
9950 Medical Center Drive                                                    1
825 and 835 Industrial Road                                                  2
3115 Merryfield Row                                                          1
201 Haskins Way                                                              1
5 and 9 Laboratory Drive                                                     2
8 and 10 Davis Drive                                                   2
201 Brookline Avenue                                                   1
10055 Barnes Canyon Road                                               1
751 Gateway Boulevard                                                  1
325 Binney Street                                                      1
1150 Eastlake Avenue East                                              1
10102 Hoyt Park Drive                                                  1
                                                                      15

Development - placed into service after January 1, 2020 Properties 9804 Medical Center Drive

                                              1
1165 Eastlake Avenue East                                              1
                                                                       2
Redevelopment - under construction                                Properties
5505 Morehouse Drive                                                   1
30-02 48th Avenue                                                      1
3160 Porter Drive                                                      1
The Arsenal on the Charles                                            11
2400 Ellis Road, 40 Moore Drive, and 14 TW Alexander Drive             3
840 Winter Street                                                      1
20400 Century Boulevard                                                1
10277 Scripps Ranch Boulevard                                          1
9601 and 9603 Medical Center Drive                                     2
One Rogers Street                                                      1
40, 50, and 60 Sylvan Road                                             3
3301, 3555, and 3755 Monte Villa Parkway                               3
Other                                                                  2
                                                                      31
Redevelopment - placed into service after January 1, 2020         Properties
9877 Waples Street                                                     1
700 Quince Orchard Road                                                1
Other                                                                  1
                                                                       3


Acquisitions after January 1, 2020                               Properties
3181 Porter Drive                                                     1
275 Grove Street                                                      1
601, 611, and 651 Gateway Boulevard                                   3
3330, 3412, 3420, 3440, 3450, and 3460 Hillview Avenue                6
9605, 9609, 9613, and 9615 Medical Center Drive                       4
9808 and 9868 Scranton Road                                           2
Alexandria Center® for Life Science - Durham                         13
One Upland Road                                                       1
830 4th Avenue South                                                  1
11255 and 11355 North Torrey Pines Road                               2
Sequence District by Alexandria                                       7
380 and 420 E Street                                                  2
Alexandria Center® for Life Science - Fenway                          1
550 Arsenal Street                                                    1
1501-1599 Industrial Road                                             6
One Investors Way                                                     2
2475 Hanover Street                                                   1
10975 and 10995 Torreyana Road                                        2
Pacific Technology Park                                               6
1122 El Camino Real                                                   1
12 Davis Drive                                                        1
7360 Carroll Road                                                     1
3303, 3305, and 3307 Monte Villa Parkway                              3
Other                                                                44
                                                                    112
Unconsolidated real estate JVs                                        4
Properties held for sale                                              -
Total properties excluded from Same Properties                      167
Same Properties                                                     247
Total properties in North America as of December 31, 2021           414


                                      111
--------------------------------------------------------------------------------

Comparison of results for the year ended December 31, 2021 to the year ended December 31, 2020



The following table presents a comparison of the components of net operating
income for our Same Properties and Non-Same Properties for the year ended
December 31, 2021, compared to the year ended December 31, 2020. Refer to the
"Non-GAAP measures and definitions" section under this Item 7 in this annual
report on Form 10-K for definitions of "Tenant recoveries" and "Net operating
income" and their reconciliations from the most directly comparable financial
measures presented in accordance with GAAP, income from rentals and net income,
respectively. We provide a comparison of the results for the year ended
December 31, 2020 to the year ended December 31, 2019, including a comparison of
the components of net operating income for our Same Properties and Non-Same
Properties for the year ended December 31, 2020, compared to the year ended
December 31, 2019, within the "Results of operations" section in Item 7 of our
annual report on Form 10-K for the year ended December 31, 2020.

                                                                            Year Ended December 31,
(Dollars in thousands)                                2021                 2020              $ Change             % Change
Income from rentals:
Same Properties                                  $ 1,220,160          $ 1,171,595          $  48,565                     4.1  %
Non-Same Properties                                  398,432              300,245             98,187                    32.7
Rental revenues                                    1,618,592            1,471,840            146,752                    10.0

Same Properties                                      406,162              370,895             35,267                     9.5
Non-Same Properties                                   83,495               35,473             48,022                   135.4
Tenant recoveries                                    489,657              406,368             83,289                    20.5

Income from rentals                                2,108,249            1,878,208            230,041                    12.2

Same Properties                                          475                  366                109                    29.8
Non-Same Properties                                    5,426                7,063             (1,637)                  (23.2)
Other income                                           5,901                7,429             (1,528)                  (20.6)

Same Properties                                    1,626,797            1,542,856             83,941                     5.4
Non-Same Properties                                  487,353              342,781            144,572                    42.2
Total revenues                                     2,114,150            1,885,637            228,513                    12.1

Same Properties                                      456,705              420,264             36,441                     8.7
Non-Same Properties                                  166,850              109,960             56,890                    51.7
Rental operations                                    623,555              530,224             93,331                    17.6

Same Properties                                    1,170,092            1,122,592             47,500                     4.2
Non-Same Properties                                  320,503              232,821             87,682                    37.7
Net operating income                             $ 1,490,595          $ 1,355,413          $ 135,182                    10.0  %

Net operating income - Same Properties           $ 1,170,092          $ 1,122,592          $  47,500                     4.2  %
Straight-line rent revenue                           (60,157)             (82,681)            22,524                   (27.2)
Amortization of acquired below-market
leases                                               (12,357)             (15,348)             2,991                   (19.5)
Net operating income - Same Properties
(cash basis)                                     $ 1,097,578          $ 1,024,563          $  73,015                     7.1  %



                                      112

--------------------------------------------------------------------------------

Income from rentals



Total income from rentals for the year ended December 31, 2021 increased by
$230.0 million, or 12.2%, to $2.1 billion, compared to $1.9 billion for the year
ended December 31, 2020 as a result of increases in rental revenues and tenant
recoveries, as discussed below.

Rental revenues



Total rental revenues for the year ended December 31, 2021, increased by $146.8
million, or 10.0%, to $1.6 billion, compared to $1.5 billion for the year ended
December 31, 2020. Excluding a termination fee of $89.5 million recognized
during the year ended December 31, 2020, our total rental revenues increased by
$236.3 million, or 17.1%, which was primarily due to an increase in rental
revenues from our Non-Same Properties related to 2.1 million RSF of development
and redevelopment projects placed into service subsequent to January 1, 2020,
and 112 operating properties aggregating 11.2 million RSF acquired subsequent to
January 1, 2020.

Rental revenues from our Same Properties for the year ended December 31, 2021
increased by $48.6 million, or 4.1%, to $1.2 billion, compared to $1.2 billion
for the year ended December 31, 2020. The increase was primarily due to rental
rate increases on lease renewals and re-leasing of space since January 1, 2020.
Refer to the "Leasing activity" section of "Item 2. Properties" within Part I of
this annual report on Form 10-K for additional details.

For further details, refer to the "Lease accounting" section in Note 2 - "Summary of significant accounting policies."

Tenant recoveries



Tenant recoveries for the year ended December 31, 2021 increased by $83.3
million, or 20.5%, to $489.7 million, compared to $406.4 million for the year
ended December 31, 2020. This increase was primarily from our Non-Same
Properties related to our development and redevelopment projects placed into
service and properties acquired subsequent to January 1, 2020, as discussed
under "Rental revenues" above.

Same Properties' tenant recoveries for the year ended December 31, 2021
increased by $35.3 million, or 9.5%, primarily due to higher property insurance,
contract services, and utilities expenses, and an increase in property tax
expenses resulting from higher assessed values of our properties during the year
ended December 31, 2021, as discussed under "Rental operations" below. As of
December 31, 2021, 91% of our leases (on an RSF basis) were triple net leases,
which require tenants to pay substantially all real estate taxes, insurance,
utilities, repairs and maintenance, common area expenses, and other operating
expenses (including increases thereto) in addition to base rent.

Other income



Other income for the years ended December 31, 2021 and 2020 was $5.9 million and
$7.4 million, respectively, which primarily consisted of construction management
fees and interest income earned during each respective period.

Rental operations



Total rental operating expenses for the year ended December 31, 2021 increased
by $93.3 million, or 17.6%, to $623.6 million, compared to $530.2 million for
the year ended December 31, 2020. The increase was primarily due to incremental
expenses related to our Non-Same Properties, which consisted of development and
redevelopment projects placed into service and acquired properties, as discussed
under "Income from rentals" above.

Same Properties' rental operating expenses increased by $36.4 million, or 8.7%,
to $456.7 million during the year ended December 31, 2021, compared to $420.3
million for the year ended December 31, 2020. The increase was primarily the
result of higher property insurance, contract services, and utilities expenses,
and increased recoverable property tax expenses driven by higher assessed values
of our properties.

General and administrative expenses



General and administrative expenses for the year ended December 31, 2021
increased by $18.1 million, or 13.6%, to $151.5 million, compared to $133.3
million for the year ended December 31, 2020. The increase was primarily due to
the continued growth in the depth and breadth of our operations in multiple
markets, including development and redevelopment projects placed into service
and properties acquired, as discussed under "Income from rentals" above. As a
percentage of net operating income, our general and administrative expenses for
the years ended December 31, 2021 and 2020 were 10.2% and 9.8%, respectively.

                                      113
--------------------------------------------------------------------------------

Interest expense

Interest expense for the years ended December 31, 2021 and 2020 consisted of the following (dollars in thousands):



                                                    Year Ended December 31,
 Component                                           2021              2020             Change
 Interest incurred                              $   312,806       $   297,227       $    15,579
 Capitalized interest                              (170,641)         (125,618)          (45,023)
 Interest expense                               $   142,165       $   171,609       $   (29,444)

 Average debt balance outstanding(1)            $ 9,071,513       $ 

7,762,498 $ 1,309,015


 Weighted-average annual interest rate(2)               3.4  %            3.8  %           (0.4) %



(1)Represents the average debt balance outstanding during the respective periods. (2)Represents total interest incurred divided by the average debt balance outstanding in the respective periods.

The net change in interest expense during the year ended December 31, 2021, compared to the year ended December 31, 2020, resulted from the following (dollars in thousands):



Component                                                   Interest Rate(1)                 Effective Date              Change
Increases in interest incurred due to:
Issuances of debt:
$700 million unsecured senior notes payable                           5.05  %                  March 2020             $   8,110
$1.0 billion unsecured senior notes payable                           1.97  %                  August 2020               11,231
$900 million unsecured senior notes payable -                         2.12  %                 February 2021              15,848
green bond
$850 million unsecured senior notes payable                           3.08  %                 February 2021              22,239
Other increase in interest                                                                                                  630
Total increases                                                                                                          58,058
Decreases in interest incurred due to:
Repayments of debt:
Secured notes payable                                                 Various                 December 2020              (3,740)
$500 million unsecured senior notes payable                           4.04  %                September 2020             (12,489)
$650 million unsecured senior notes payable -                         4.03  %                  March 2021               (22,217)
green bond
Fluctuations in interest rate and average
balance:
Unsecured senior line of credit                                                                                          (1,581)
$1.5 billion commercial paper program                                                                                    (2,452)
Total decreases                                                                                                         (42,479)
Change in gross interest                                                                                                 15,579
Increase in capitalized interest                                                                                        (45,023)
Total change in interest expense                                                                                      $ (29,444)

(1)Represents the weighted-average interest rate as of the end of the applicable period, including amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

Depreciation and amortization



Depreciation and amortization expense for the year ended December 31, 2021
increased by $123.0 million, or 17.6%, to $821.1 million, compared to $698.1
million for the year ended December 31, 2020. The increase was primarily due to
additional depreciation from 2.1 million RSF of development and redevelopment
projects placed into service subsequent to January 1, 2020, and 112 operating
properties aggregating 11.2 million RSF acquired subsequent to January 1, 2020.

                                      114
--------------------------------------------------------------------------------

Impairment of real estate

During the year ended December 31, 2021, we recognized real estate asset impairments of office-related properties aggregating $52.7 million, primarily consisting of the following:



•Impairment charge of $22.5 million during the three months ended September 30,
2021, upon classification as held for sale of an option to purchase a land
parcel in our SoMa submarket for the development of an office property, to
reduce the option's carrying amount to its estimated fair value less costs to
sell. We completed the sales of the option during the three months ended
December 31, 2021, at no gain or loss.
•Impairment charge of $18.6 million during the three months ended September 30,
2021, to reduce the carrying amount of a property located in a non-core
submarket to its estimated fair value less costs to sell, upon our review of the
current local market conditions.
•Impairment charges aggregating $6.9 million during the six months ended June
30, 2021, to further reduce the carrying amounts of three office properties
located in our San Francisco Bay Area and Seattle markets to their estimated
fair values less costs to sell, based on the sales price negotiated for each
property during this period. We completed the sales of these properties during
the three months ended September 30, 2021. These properties met the
held-for-sale classification during 2020, as discussed below.

During the year ended December 31, 2020, we recognized real estate asset impairments of office-related properties aggregating $48.1 million, primarily consisting of the following:



•Impairment charges aggregating $25.2 million during the three months ended
December 31, 2020 to reduce the carrying amounts of three office properties
located in our San Francisco Bay Area and Seattle markets to their estimated
fair values less costs to sell, upon classification of these properties as held
for sale. As discussed above, we completed the sales of these properties during
the three months ended September 30, 2021.
•Impairment charge of $6.8 million recognized during the three months ended
September 30, 2020, upon classification of our real estate asset located at 945
Market Street in our SoMa submarket as held for sale. We completed the sale of
this real estate asset in September 2020.
•Impairment charges aggregating $15.2 million, which mainly consisted of a $10
million write-off of the pre-acquisition deposit for a previously pending
acquisition of an operating tech office property for which our revised economic
projections declined from our initial underwriting. We recognized this
impairment charge in April 2020 concurrently with the submission of our notice
to terminate the transaction.

Loss on early extinguishment of debt



During the year ended December 31, 2021, we recognized a loss on early
extinguishment of debt of $67.3 million, including the write-off of unamortized
loan fees primarily related to the refinancing of our 4.00% unsecured senior
notes payable aggregating $650.0 million due in 2024 pursuant to a partial cash
tender offer completed on February 10, 2021, and a subsequent call for
redemption for the remaining outstanding amounts completed on March 12, 2021.

During the year ended December 31, 2020, we refinanced our 3.90% unsecured
senior notes payable due in 2023 aggregating $500.0 million and recognized a
loss on early extinguishment of debt of $50.8 million, including the write-off
of unamortized loan fees. Additionally, we recognized a loss on early
extinguishment of debt of $1.9 million due to the termination of our $750.0
million unsecured senior line of credit.

Equity in earnings of unconsolidated real estate joint ventures

During the year ended December 31, 2021, we recognized equity in earnings of unconsolidated real estate joint ventures of $12.3 million.



During the year ended December 31, 2020, we recognized equity in earnings of
unconsolidated real estate joint ventures aggregating $8.1 million. This balance
consisted of earnings from our unconsolidated real estate joint ventures of
approximately $15.8 million, partially offset by an impairment charge on one of
our unconsolidated real estate joint ventures. In March 2020, the impact of
COVID-19 pandemic led to the temporary closure of a retail center owned by our
1401/1413 Research Boulevard unconsolidated real estate joint venture. We
evaluated the recoverability of our investment in this joint venture and
recognized a $7.6 million impairment charge to lower the carrying amount of our
investment balance, which primarily consisted of real estate, to zero.

Refer to Note 4 - "Consolidated and unconsolidated real estate joint ventures"
to our consolidated financial statements under Item 15 in this annual report on
Form 10-K for additional information.
                                      115
--------------------------------------------------------------------------------

Investment income



During the year ended December 31, 2021, we recognized investment income
aggregating $259.5 million, which consisted of $215.8 million of realized gains
and $43.6 million of unrealized gains. Realized gains of $215.8 million
primarily consisted of sales of investments and distributions received.
Unrealized gains of $43.6 million during the year ended December 31, 2021,
primarily consisted of increases in fair values of our investments in privately
held entities that report NAV.

During the year ended December 31, 2020, we recognized investment income aggregating $421.3 million, which consisted of $47.3 million of realized gains and $374.0 million of unrealized gains.



For more information about our investments, refer to Note 7 - "Investments" to
our consolidated financial statements under Item 15 in this annual report on
Form 10-K. For our impairments accounting policy, refer to the "Investments"
section in Note 2 - "Summary of significant accounting policies" to our
consolidated financial statements under Item 15 in this annual report on Form
10-K.

Gain on sales of real estate

During the year ended December 31, 2021, we recognized gain on sales of real
estate aggregating $126.6 million, which included a $101.1 million gain
recognized in connection with the sale of our entire 49.0% interest in the
unconsolidated real estate joint venture at Menlo Gateway and a $23.2 million
gain recognized in connection with the sale of our 2301 5th Avenue property
aggregating 197,135 RSF located in our Lake Union submarket of Seattle. The
gains were classified in gain on sales of real estate within our consolidated
statements of operations for the year ended December 31, 2021.

During the year ended December 31, 2020, we recognized gain on sales of real
estate aggregating $154.1 million, which included $151.9 million of gains
recognized in connection with the sale of two tech office properties at 510
Townsend Street and 505 Brannan Street in our SoMa submarket and $1.6 million of
gains recognized in connection with the sale of 30 Bearfoot Road in our Route
495 submarket.

Other comprehensive income

Total other comprehensive income for the year ended December 31, 2021, decreased
by $3.8 million to aggregate net unrealized losses of $0.7 million, compared to
net unrealized gains of $3.1 million for the year ended December 31, 2020,
primarily due to the unrealized gains (losses) on foreign currency translation
related to our operations in Canada and China.


                                      116
--------------------------------------------------------------------------------

Summary of capital expenditures

Our construction spending for the year ended December 31, 2021 consisted of the following (in thousands):


                                                                      Year 

Ended


  Construction Spending                                           December 

31, 2021


  Additions to real estate - consolidated projects               $        

2,089,849


  Investments in unconsolidated real estate joint ventures                  

13,666


  Contributions from noncontrolling interests                               

(94,285)


  Construction spending (cash basis)                                      

2,009,230


  Change in accrued construction                                            149,939
  Construction spending                                          $        2,159,169

The following table summarizes the total projected construction spending for the year ending December 31, 2022, which includes interest, property taxes, insurance, payroll, and other indirect project costs (in thousands):


                                                                                    Year Ending
Projected Construction Spending                                                  December 31, 2022
Development, redevelopment, and pre-construction projects                   

$ 2,990,000 Contributions from noncontrolling interests (consolidated real estate joint ventures)

                                                                          (220,000)
Revenue-enhancing and repositioning capital expenditures                                   98,000
Non-revenue-enhancing capital expenditures                                                 82,000
Guidance midpoint                                                              $        2,950,000


                                      117

--------------------------------------------------------------------------------

Projected results



Based on our current view of existing market conditions and certain current
assumptions, we present guidance for EPS attributable to Alexandria's common
stockholders - diluted and funds from operations per share attributable to
Alexandria's common stockholders - diluted for the year ending December 31,
2022, as set forth in the table below. The tables below also provide a
reconciliation of EPS attributable to Alexandria's common stockholders -
diluted, the most directly comparable financial measure presented in accordance
with GAAP, to funds from operations per share, a non-GAAP measure, and other key
assumptions included in our updated guidance for the year ending December 31,
2022. There can be no assurance that actual amounts will not be materially
higher or lower than these expectations. Refer to our discussion of
"Forward-looking statements" in this annual report on Form 10-K.

Projected 2022 Earnings per Share and Funds From Operations per Share Attributable to Alexandria's Common
Stockholders - Diluted
Earnings per share(1)                                                                 $2.65 to $2.85
Depreciation and amortization of real estate assets                                        5.65

Allocation of unvested restricted stock awards                                            (0.04)
Funds from operations per share(2)                                                    $8.26 to $8.46

Midpoint                                                                                   $8.36


(1)Excludes unrealized gains or losses after December 31, 2021 that are required
to be recognized in earnings and are excluded from funds from operations per
share, as adjusted.
(2)Calculated in accordance with standards established by the Advisory Board of
Governors of Nareit (the "Nareit Board of Governors"). Refer to the definition
of "Funds from operations and funds from operations, as adjusted, attributable
to Alexandria Real Estate Equities, Inc.'s common stockholders" in the "Non-GAAP
measures and definitions" section under this Item 7 in this annual report on
Form 10-K for additional information.
Key Assumptions(1)                                                                 2022 Guidance
(Dollars in millions)                                                        Low                 High

Occupancy percentage for operating properties in North America as of December 31, 2022

                                                            95.2%           95.8%
Lease renewals and re-leasing of space:
Rental rate increases                                                           30.0%           35.0%
Rental rate increases (cash basis)                                              18.0%           23.0%
Same property performance:
Net operating income increase                                                    5.5%            7.5%
Net operating income increase (cash basis)                                       6.5%            8.5%
Straight-line rent revenue                                              $      150          $  160
General and administrative expenses                                     $      168          $  176
Capitalization of interest                                              $      269          $  279
Interest expense                                                        $       90          $  100


(1)Our assumptions presented in the table above are subject to a number of
variables and uncertainties, including those discussed as "Forward-looking
statements" under Part I; "Item 1A. Risk factors"; and Item 7. Management's
discussion and analysis of financial condition and results of operations in this
annual report on Form 10-K. To the extent our full-year earnings guidance is
updated during the year, we will provide additional disclosure supporting
reasons for any significant changes to such guidance.

Key Credit Metrics                                                          2022 Guidance
Net debt and preferred stock to Adjusted EBITDA - fourth quarter        Less than or equal to
of 2022, annualized                                                              5.1x
                                                                       Greater than or equal to
Fixed-charge coverage ratio - fourth quarter of 2022, annualized            

5.1x


                                      118
--------------------------------------------------------------------------------

Consolidated and unconsolidated real estate joint ventures



We present components of balance sheet and operating results information for the
noncontrolling interest share of our consolidated real estate joint ventures and
for our share of investments in unconsolidated real estate joint ventures to
help investors estimate balance sheet and operating results information related
to our partially owned entities. These amounts are estimated by computing, for
each joint venture that we consolidate in our financial statements, the
noncontrolling interest percentage of each financial item to arrive at the
cumulative noncontrolling interest share of each component presented. In
addition, for our real estate joint ventures that we do not control and do not
consolidate, we apply our economic ownership percentage to the unconsolidated
real estate joint ventures to arrive at our proportionate share of each
component presented. Refer to Note 4 - "Consolidated and unconsolidated real
estate joint ventures" to our consolidated financial statements under Item 15 in
this annual report on Form 10-K for further discussion.
Consolidated Real Estate Joint Ventures
                                                                                                Noncontrolling(1)                           Operating RSF
                           Property/Market/Submarket                                              Interest Share                               at 100%
50 and 60 Binney Street/Greater Boston/Cambridge/Inner Suburbs                                                66.0  % (2)                      532,395
75/125 Binney Street/Greater Boston/Cambridge/Inner Suburbs                                                   60.0  %                          388,270
225 Binney Street/Greater Boston/Cambridge/Inner Suburbs                                                      70.0  %                          305,212
99 Coolidge Avenue/Greater Boston/Cambridge/Inner Suburbs                                                     25.0  %                                -  

(3)


409 and 499 Illinois Street/San Francisco Bay Area/Mission Bay                                                75.0  % (2)                      455,069
1500 Owens Street/San Francisco Bay Area/Mission Bay                                                          75.0  % (2)                      158,267
1700 Owens Street/San Francisco Bay Area/Mission Bay                                                          75.0  % (2)                      164,513

455 Mission Bay Boulevard South/San Francisco Bay Area/Mission Bay

                                   75.0  % (2)                      228,140

Alexandria Technology Center® - Gateway/San Francisco Bay Area/South San Francisco(4)

                                                                                                  50.1  %                        1,089,852
213 East Grand Avenue/San Francisco Bay Area/South San Francisco                                              70.0  % (2)                      300,930
500 Forbes Boulevard/San Francisco Bay Area/South San Francisco                                               90.0  %                          155,685

Alexandria Center® for Life Science - Millbrae Station/San Francisco Bay

                                    59.7  %                                -
Area/South San Francisco
Alexandria Point/San Diego/University Town Center(5)                                                          45.0  %                        1,337,916
5200 Illumina Way/San Diego/University Town Center                                                            49.0  %                          792,687
9625 Towne Centre Drive/San Diego/University Town Center                                                      49.9  %                          163,648
SD Tech by Alexandria/San Diego/Sorrento Mesa(6)                                                              50.0  %                          679,801
Pacific Technology Park/San Diego/Sorrento Mesa                                                               50.0  % (2)                      632,732

1201 and 1208 Eastlake Avenue East and 199 East Blaine Street /Seattle/Lake Union

                                                                                                         70.0  %                          321,218
400 Dexter Avenue North/Seattle/Lake Union                                                                    70.0  % (2)                      290,111

Unconsolidated Real Estate Joint Ventures


                                                                                                                                            Operating RSF
                           Property/Market/Submarket                                          Our Ownership Share(7)                           at 100%
1655 and 1725 Third Street/San Francisco Bay Area/Mission Bay                                                 10.0  %                              

586,208


1401/1413 Research Boulevard/Maryland/Rockville                                                               65.0  % (8)                        (9)
1450 Research Boulevard/Maryland/Rockville                                                                    73.2  % (10)                      42,679
101 West Dickman Street/Maryland/Beltsville                                                                   57.9  % (10)                     135,423


(1)In addition to the consolidated real estate joint ventures listed, various
partners hold insignificant noncontrolling interests in three other real estate
joint ventures in North America.
(2)Refer to "Formation of consolidated real estate joint ventures and sales of
partial interest" subsection in Note 4 - "Consolidated and unconsolidated real
estate joint ventures" under Item 15 in this annual report on Form 10-K for
additional information.
(3)We expect to commence vertical construction of 275,000 RSF during 2022.
(4)Includes 601, 611, 651, 681, 685, 701, and 751 Gateway Boulevard in our South
San Francisco submarket. Noncontrolling interest share is anticipated to be 49%
as we make further contributions into the joint venture over time.
(5)Includes 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224,
and 4242 Campus Point Court in our University Town Center submarket.
(6)Includes 9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton
Road and 10055 and 10065 Barnes Canyon Road in our Sorrento Mesa submarket.
(7)In addition to the unconsolidated real estate joint ventures listed, we hold
an interest in one other insignificant unconsolidated real estate joint venture
in North America.
(8)Represents our ownership interest; our voting interest is limited to 50%.
(9)Represents a joint venture with a distinguished retail real estate developer
for an approximate 90,000 RSF retail shopping center.
(10)Represent joint ventures with local real estate operators. Each of these
joint ventures operates one office property which are expected to be redeveloped
into office/lab. Our investments into 101 West Dickman Street and 1450 Research
Boulevard joint ventures were $8.3 million and $4.0 million, respectively. The
joint ventures each have a construction loan in place which is expected to fund
future redevelopment cost; therefore, we expect minimal equity contributions to
be required in the future. Our partners manage the day-to-day activities that
most significantly affect the economic performance of each joint venture;
therefore, we account for these investments under the equity method of
accounting.
                                      119
--------------------------------------------------------------------------------


The following table presents key terms related to our unconsolidated real estate
joint ventures' secured loans as of December 31, 2021 (dollars in thousands):
                                                                                                                                                             Aggregate
                                                                                                                                                             Commitment           Debt Balance
    Unconsolidated Joint Venture            Our Share               

Maturity Date                  Stated Rate               Interest Rate(1)                at 100%              at 100%(2)
1401/1413 Research Boulevard                  65.0%                      12/23/24                      2.70%                           3.14  %             $    28,500          $      28,124
1655 and 1725 Third Street                    10.0%                      3/10/25                       4.50%                           4.57  %                 600,000                598,657
101 West Dickman Street                       57.9%                      11/10/26                  SOFR + 1.95%    (3)                 2.81  %                  26,750                  9,947
1450 Research Boulevard                       73.2%                      12/10/26                  SOFR + 1.95%    (3)                     N/A                  13,000                      -
                                                                                                                                                           $   668,250          $     636,728

(1)Includes interest expense and amortization of loan fees. (2)Represents outstanding principal, net of unamortized deferred financing costs, as of December 31, 2021. (3)This loan is subject to a fixed SOFR floor rate of 0.75%.



The following tables present information related to the operating results and
financial positions of our consolidated and unconsolidated real estate joint
ventures (in thousands):
                                        Noncontrolling Interest Share of                  Our Share of Unconsolidated
                                    Consolidated Real Estate Joint Ventures               Real Estate Joint Ventures
                                               December 31, 2021                               December 31, 2021
                                                                                      Three Months
                                   Three Months Ended           Year Ended               Ended                Year Ended
Total revenues                     $         64,273          $     211,807          $       9,962          $      43,557
Rental operations                           (18,278)               (58,123)                (1,469)                (7,079)
                                             45,995                153,684                  8,493                 36,478
General and administrative                      (36)                  (635)                  (113)                  (298)
Interest                                          -                      -                 (2,304)               (10,191)
Depreciation and amortization               (21,265)               (70,880)                (3,058)               (13,734)

Fixed returns allocated to
redeemable noncontrolling
interests(1)                                    207                    866                      -                      -
                                   $         24,901          $      83,035          $       3,018          $      12,255

Straight-line rent and
below-market lease revenue         $          1,859          $       5,318          $         170          $       3,094
Funds from operations(2)           $         46,166          $     153,915          $       6,076          $      25,989



(1)Represents an allocation of joint venture earnings to redeemable
noncontrolling interests primarily in one property in our South San Francisco
submarket. These redeemable noncontrolling interests earn a fixed return on
their investment rather than participate in the operating results of the
property.
(2)Refer to the definition of "Funds from operations and funds from operations,
as adjusted, attributable to Alexandria Real Estate Equities, Inc.'s common
stockholders" in the "Non-GAAP measures and definitions" section under this Item
7 in this annual report on Form 10-K for the definition and the reconciliation
from the most directly comparable financial measure presented in accordance with
GAAP.

                                                                As of December 31, 2021
                                                       Noncontrolling
                                                     Interest Share of             Our Share of
                                                     Consolidated Real            Unconsolidated
                                                        Estate Joint             Real Estate Joint
                                                          Ventures                   Ventures
Investments in real estate                          $       2,580,819          $          110,432
Cash, cash equivalents, and restricted cash                    92,703                       4,993
Other assets                                                  290,389                      10,168
Secured notes payable                                          (1,998)                    (83,910)
Other liabilities                                            (118,205)                     (3,200)
Redeemable noncontrolling interests                            (9,612)                          -
                                                    $       2,834,096          $           38,483



During the years ended December 31, 2021 and 2020, our consolidated real estate
joint ventures distributed an aggregate of $112.4 million and $87.3 million,
respectively, to our joint venture partners. Refer to our consolidated
statements of cash flows and Note 4 - "Consolidated and unconsolidated real
estate joint ventures" to our consolidated financial statements under Item 15 in
this annual report on Form 10-K for additional information.
                                      120
--------------------------------------------------------------------------------

Investments


We hold investments in publicly traded companies and privately held entities
primarily involved in the life science, agtech, and technology industries. The
tables below summarize components of our non-real estate investments and
investment income. Refer to Note 7 - "Investments" to our consolidated financial
statements under Item 15 in this annual report on Form 10-K for additional
information.

                                                                  December 31, 2021
                                                                                                             Year Ended December 31,
(In thousands)                                     Three Months Ended               Year Ended                        2020
Realized gains                                   $     26,832                 $    215,845    (1)          $          47,288    (2)
Unrealized (losses) gains                            (139,716)                      43,632                           374,033
Investment (loss) income                         $   (112,884)                $    259,477                 $         421,321



Investments                                                                      Unrealized
(In thousands)                                            Cost                      Gains                   Carrying Amount
Publicly traded companies                         $   203,290                $  280,527    (3)         $        483,817
Entities that report NAV                              385,692                   444,172                         829,864
Entities that do not report NAV:
Entities with observable price changes                 56,257                    72,974                         129,231
Entities without observable price changes             362,064                         -                         362,064
Investments accounted for under the equity
method of accounting                                         N/A                       N/A                       71,588
December 31, 2021                                 $ 1,007,303    (4)         $  797,673                $      1,876,564

December 31, 2020                                 $   835,438                $  775,676                $      1,611,114



(1)Includes six separate significant realized gains aggregating $110.1 million
related to the following transactions: (i) the sales of investments in three
publicly traded biotechnology companies, (ii) a distribution received from a
limited partnership investment, and (iii) the acquisition of two of our
privately held non-real estate investments in a biopharmaceutical company and
biotechnology company.
(2)Includes impairments of $24.5 million related to investments in privately
held entities that do not report NAV.
(3)Includes gross unrealized gains and losses of $310.0 million and $29.5
million, respectively, as of December 31, 2021.
(4)Represents 3.0% of gross assets as of December 31, 2021.


                Public/Private
                  Mix (Cost)
    [[Image Removed: are-20211231_g54.jpg]]

               Tenant/Non-Tenant
                  Mix (Cost)
    [[Image Removed: are-20211231_g55.jpg]]


                                      121

--------------------------------------------------------------------------------

Liquidity


                                                                                 Minimal Outstanding Borrowings and Significant Availability on Unsecured Senior
                       Liquidity                                                                                  Line of Credit
                                                               (in millions)


                         $5.4B



(In millions)
Availability under our unsecured senior line                                                         [[Image Removed: are-20211231_g56.jpg]]
of credit, net of amounts outstanding under
our commercial paper program                  $ 2,730
Remaining construction loan commitments           185

Cash, cash equivalents, and restricted cash 415 Investments in publicly traded companies 484 Liquidity as of December 31, 2021

               3,814
Outstanding forward equity sales
agreements(1)                                   1,621
Total                                         $ 5,435

(1)Represents expected net proceeds from the future settlement of 8.1 million shares of forward equity sales agreements entered into in January 2022.



We expect to meet certain long-term liquidity requirements, such as requirements
for development, redevelopment, other construction projects, capital
improvements, tenant improvements, property acquisitions, leasing costs,
non-revenue-enhancing capital expenditures, scheduled debt maturities,
distributions to noncontrolling interests, and payment of dividends through net
cash provided by operating activities, periodic asset sales, strategic real
estate joint venture capital, long-term secured and unsecured indebtedness,
borrowings under our unsecured senior line of credit, issuances under our
commercial paper program, and issuances of additional debt and/or equity
securities.

We also expect to continue meeting our short-term liquidity and capital
requirements, as further detailed in this section, generally through our working
capital and net cash provided by operating activities. We believe that the net
cash provided by operating activities will continue to be sufficient to enable
us to make the distributions necessary to continue qualifying as a REIT.

For additional information on our liquidity requirements related to our
contractual obligations and commitments, refer to Note 5 - "Leases" and Note 10
- "Secured and unsecured senior debt" to our consolidated financial statements
under Item 15 in this annual report on Form 10-K for additional information.

Over the next several years, our balance sheet, capital structure, and liquidity objectives are as follows:



•Retain positive cash flows from operating activities after payment of dividends
and distributions to noncontrolling interests for investment in development and
redevelopment projects and/or acquisitions;
•Improve credit profile and relative long-term cost of capital;
•Maintain diverse sources of capital, including sources from net cash provided
by operating activities, unsecured debt, secured debt, selective real estate
asset sales, partial interest sales, non-real estate investment sales, and
common stock;
•Maintain commitment to long-term capital to fund growth;
•Maintain prudent laddering of debt maturities;
•Maintain solid credit metrics;
•Maintain significant balance sheet liquidity;
•Prudently manage variable-rate debt exposure through the reduction of
short-term and medium-term variable-rate debt;
•Maintain a large unencumbered asset pool to provide financial flexibility;
•Fund common stock dividends and distributions to noncontrolling interests from
net cash provided by operating activities;
•Manage a disciplined level of value-creation projects as a percentage of our
gross real estate assets; and
•Maintain high levels of pre-leasing and percentage leased in value-creation
projects.

                                      122
--------------------------------------------------------------------------------

The following table presents the availability under our unsecured senior line of
credit, net of amounts outstanding under our commercial paper program;
availability under our secured construction loan; outstanding forward equity
sales agreements; cash, cash equivalents, and restricted cash; and investments
in publicly traded companies as of December 31, 2021 (dollars in thousands):

                                                       Stated                  Aggregate            Outstanding                 Remaining
              Description                               Rate                  Commitments           Balance(1)            Commitments/Liquidity
Availability under our unsecured senior
line of credit, net of amounts
outstanding under our commercial paper
program                                               L+0.815%               $ 3,000,000          $    269,990          $             2,730,000
Remaining construction loan commitments                 SOFR + 2.70  %       $   195,300          $      7,991                          185,298

Cash, cash equivalents, and restricted
cash                                                                                                                                    415,227
Investments in publicly traded companies                                                                                                483,817
Liquidity as of December 31, 2021                                                                                                     3,814,342
Outstanding forward equity sales
agreements(2)                                                                                                                         1,621,180
Total                                                                                                                   $             5,435,522



(1)Represents outstanding principal, net of unamortized deferred financing
costs, as of December 31, 2021.
(2)Represents expected net proceeds from the future settlement of 8.1 million
shares of forward equity sales agreements entered into in January 2022.

Cash, cash equivalents, and restricted cash



As of December 31, 2021 and 2020, we had $415.2 million and $597.7 million,
respectively, of cash, cash equivalents, and restricted cash. We expect existing
cash, cash equivalents, and restricted cash, net cash from operating activities,
proceeds from real estate asset sales and partial interest sales, non-real
estate investment sales, borrowings under our unsecured senior line of credit,
issuances under our commercial paper program, issuances of unsecured notes
payable, borrowings under secured construction loans, and issuances of common
stock to continue to be sufficient to fund our operating activities and cash
commitments for investing and financing activities, such as regular quarterly
dividends, distributions to noncontrolling interests, scheduled debt repayments,
acquisitions, and certain capital expenditures, including expenditures related
to construction activities.

                                      123
--------------------------------------------------------------------------------

Cash flows



We report and analyze our cash flows based on operating activities, investing
activities, and financing activities. The following table summarizes changes in
our cash flows for the years ended December 31, 2021 and 2020 (in thousands):

                                                 Year Ended December 31,
                                                  2021              2020             Change

Net cash provided by operating activities $ 1,010,197 $ 882,510

$    127,687
Net cash used in investing activities        $ (7,107,324)     $ (3,278,161)     $ (3,829,163)
Net cash provided by financing activities    $  5,916,361      $  2,750,356      $  3,166,005



Operating activities

Cash flows provided by operating activities are primarily dependent upon the
occupancy level of our asset base, the rental rates of our leases, the
collectibility of rent and recovery of operating expenses from our tenants, the
timing of completion of development and redevelopment projects, and the timing
of acquisitions and dispositions of operating properties. Net cash provided by
operating activities for the year ended December 31, 2021 increased by $127.7
million to $1.0 billion, compared to $882.5 million for the year ended December
31, 2020. This increase was primarily attributable to (i) cash flows generated
from our highly leased development and redevelopment projects recently placed
into service, (ii) income-producing acquisitions since January 1, 2020, and
(iii) increases in rental rates on lease renewals and re-leasing of space since
January 1, 2020.

Investing activities

Cash used in investing activities for the years ended December 31, 2021 and 2020 consisted of the following (in thousands):



                                                              Year Ended December 31,
                                                                                                       Increase
                                                             2021                  2020               (Decrease)
Sources of cash from investing activities:
Sales of and distributions from non-real estate
investments                                             $    424,623          $   141,149          $     283,474
Proceeds from sales of real estate                           190,576              747,020               (556,444)

Return of capital from unconsolidated real estate joint ventures

                                                           -               20,225                (20,225)
Sale of interests in unconsolidated real estate joint
ventures                                                     394,952                    -                394,952
Change in escrow deposits                                          -                7,408                 (7,408)
                                                           1,010,151              915,802                 94,349
Uses of cash for investing activities:
Purchases of real estate                                   5,434,652            2,570,693              2,863,959
Additions to real estate                                   2,089,849            1,445,171                644,678

Acquisition of interest in unconsolidated real estate joint venture

                                                  9,048                    -                  9,048
Investments in unconsolidated real estate joint
ventures                                                      13,666                3,444                 10,222
Additions to non-real estate investments                     408,564              174,655                233,909
Change in escrow deposits                                    161,696                    -                161,696
                                                           8,117,475            4,193,963              3,923,512

Net cash used in investing activities                   $  7,107,324

$ 3,278,161 $ 3,829,163





The increase in net cash used in investing activities for the year ended
December 31, 2021 was primarily due to an increased use of cash for property
acquisitions, additions to real estate, and additions to non-real estate
investments. Refer to Note 3 - "Investments in real estate" to our consolidated
financial statements under Item 15 in this annual report on Form 10-K for
further information.

                                      124
--------------------------------------------------------------------------------

Financing activities

Cash flows provided by financing activities for the years ended December 31, 2021 and 2020 consisted of the following (in thousands):


                                                             Year Ended 

December 31,


                                                           2021                  2020                 Change
Borrowings from secured notes payable                 $     10,005          $          -          $    10,005
Repayments of borrowings from secured notes payable        (17,979)              (84,104)              66,125
Payment for the defeasance of secured note payable               -               (32,865)              32,865
Proceeds from issuance of unsecured senior notes
payable                                                  1,743,716             1,697,651               46,065
Repayments of unsecured senior notes payable              (650,000)             (500,000)            (150,000)
Premium paid for early extinguishment of debt              (66,829)              (54,385)             (12,444)

Borrowings from unsecured senior line of credit 3,521,000

    2,700,000              821,000

Repayments of borrowings from unsecured senior line of credit

                                               (3,521,000)           (3,084,000)            (437,000)

Proceeds from issuance under commercial paper program 30,951,300

   23,539,400            7,411,900
Repayments of borrowings from commercial paper
program                                                (30,781,300)          (23,439,400)          (7,341,900)
Payments of loan fees                                      (18,938)              (32,309)              13,371
Changes related to debt                                  1,169,975               709,988              459,987

Contributions from and sales of noncontrolling
interests                                                2,026,486               367,613            1,658,873
Distributions to and purchases of noncontrolling
interests                                                 (118,891)              (88,805)             (30,086)
Proceeds from the issuance of common stock               3,529,097             2,315,862            1,213,235
Dividend payments                                         (655,968)             (532,980)            (122,988)

Taxes paid related to net settlement of equity awards (34,338)

      (21,322)             (13,016)
Net cash provided by financing activities             $  5,916,361          $  2,750,356          $ 3,166,005



                                      125

--------------------------------------------------------------------------------

Capital resources



We expect that our principal liquidity needs for the year ending December 31,
2022, will be satisfied by the following multiple sources of capital, as shown
in the table below. There can be no assurance that our sources and uses of
capital will not be materially higher or lower than these expectations.
Key Sources and Uses of Capital                                          2022 Guidance                         Certain Completed
(In millions)                                                       Range                   Midpoint                 Items
Sources of capital:
Net cash provided by operating activities after
dividends                                                $   275          $   325          $    300
Incremental debt                                           1,375            1,025             1,200

Real estate dispositions and partial interest              1,300            2,100             1,700
sales
Common equity                                              2,250            3,250             2,750          $      1,691
Total sources of capital                                 $ 5,200          $ 6,700          $  5,950

Uses of capital:
Construction                                             $ 2,700          $ 3,200          $  2,950
Acquisitions                                               2,500            3,500             3,000          $      1,220

Total uses of capital                                    $ 5,200          $ 6,700          $  5,950

Incremental debt (included above):
Issuance of unsecured senior notes payable               $ 1,200          $ 

1,700 $ 1,450



Unsecured senior line of credit, commercial paper
program, and other                                           175             (675)             (250)
Incremental debt                                         $ 1,375          $ 1,025          $  1,200



The key assumptions behind the sources and uses of capital in the table above
include a favorable capital market environment, performance of our core
operating properties, lease-up and delivery of current and future development
and redevelopment projects, and leasing activity. Our expected sources and uses
of capital are subject to a number of variables and uncertainties, including
those discussed as "Forward-looking statements" under Part I; "Item 1A. Risk
factors"; and "Item 7. Management's discussion and analysis of financial
condition and results of operations" in this annual report on Form 10-K. We
expect to update our forecast of sources and uses of capital on a quarterly
basis.

                                      126
--------------------------------------------------------------------------------

Sources of capital

Net cash provided by operating activities after dividends



We expect to retain $275.0 million to $325.0 million of net cash flows from
operating activities after payment of common stock dividends, and distributions
to noncontrolling interests for the year ending December 31, 2022. For purposes
of this calculation, changes in operating assets and liabilities are excluded as
they represent timing differences. For the year ending December 31, 2022, we
expect our recently delivered projects, our highly pre-leased value-creation
projects expected to be completed, and contributions from Same Properties and
recently acquired properties to contribute significant increases in income from
rentals, net operating income, and cash flows. We anticipate significant
contractual near-term growth in annual cash rents of $39 million related to the
commencement of contractual rents on the projects recently placed into service
that are near the end of their initial free rent period. Refer to the "Cash
flows" section within this Item 7 in this annual report on Form 10-K for a
discussion of cash flows provided by operating activities for the year ended
December 31, 2021.

Debt

We expect to fund a portion of our capital needs in 2022 from the real estate
dispositions and partial interest sales, settlement of our outstanding forward
equity sales agreements, sales of our common stock under our ATM program,
issuances under our commercial paper program discussed below, borrowings under
our unsecured senior line of credit, and issuances of unsecured senior notes
payable.

As of December 31, 2021, we have no outstanding balance on our unsecured senior
line of credit. Our unsecured senior line of credit has an aggregate commitment
of $3.0 billion and bears an interest rate of LIBOR plus 0.825% with a 0% LIBOR
floor and is subject to certain annual sustainability measures entitling us to a
temporary reduction in the interest rate margin of one basis point, but not
below zero percent per year. During the year ended December 31, 2020, we
achieved certain sustainability measures, as described in our unsecured senior
line of credit agreement, which reduced our borrowing rate to LIBOR plus 0.815%
for a one-year period. In addition to the cost of borrowing, the unsecured
senior line of credit is subject to an annual facility fee of 0.15% based on the
aggregate commitments outstanding.

We use our unsecured senior line of credit to fund working capital, construction
activities, and, from time to time, acquisition of properties. Borrowings under
the unsecured senior line of credit bear interest at a "Eurocurrency Rate," a
"LIBOR Floating Rate," or a "Base Rate" specified in the unsecured senior line
of credit agreement plus, in any case, the Applicable Margin. The Eurocurrency
Rate specified in the unsecured senior line of credit agreement is, as
applicable, the rate per annum equal to either (i) the LIBOR or a successor rate
thereto as agreed to by the administrative agent and the Company for loans
denominated in a LIBOR quoted currency (i.e., U.S. dollars, euro, sterling, or
yen), (ii) the average annual yield rates applicable to Canadian dollar bankers'
acceptances for loans denominated in Canadian dollars, (iii) the Bank Bill Swap
Reference Bid rate for loans denominated in Australian dollars, or (iv) the rate
designated with respect to the applicable alternative currency for loans
denominated in a non-LIBOR quoted currency (other than Canadian or Australian
dollars). The LIBOR Floating Rate means, for any day, one-month LIBOR, or a
successor rate thereto as agreed to by the administrative agent and the Company
for loans denominated in U.S. dollars. The Base Rate means, for any day, a
fluctuating rate per annum equal to the highest of (i) the federal funds rate
plus 1/2 of 1.00%, (ii) the rate of interest in effect for such day as publicly
announced from time to time by the Administrative Agent as its "prime rate," and
(iii) the Eurocurrency Rate plus 1.00%. Our unsecured senior line of credit
contains a feature that allows lenders to competitively bid on the interest rate
for borrowings under the facility. This may result in an interest rate that is
below the stated rate.

We established a commercial paper program that provides us with the ability to
issue up to $1.5 billion of commercial paper notes with a maturity of generally
30 days or less and with a maximum maturity of 397 days from the date of
issuance. Our commercial paper program is backed by our unsecured senior line of
credit, and at all times we expect to retain a minimum undrawn amount of
borrowing capacity under our unsecured senior line of credit equal to any
outstanding balance on our commercial paper program. We use borrowings under the
program to fund short-term capital needs. The notes issued under our commercial
paper program are sold under customary terms in the commercial paper market.
They are typically issued at a discount to par, representing a yield to maturity
dictated by market conditions at the time of issuance. In the event we are
unable to issue commercial paper notes or refinance outstanding commercial paper
notes under terms equal to or more favorable than those under the unsecured
senior line of credit, we expect to borrow under the unsecured senior line of
credit at LIBOR plus 0.815%. The commercial paper notes sold during the three
months ended December 31, 2021 were issued at a weighted-average yield to
maturity of 0.24%. As of December 31, 2021, we had an aggregate of
$270.0 million of notes outstanding under our commercial paper program.

In February 2021, we opportunistically issued $1.75 billion of unsecured senior
notes payable with a weighted-average interest rate of 2.49% and a
weighted-average maturity of 20.4 years. The unsecured senior notes consisted of
$900.0 million of 2.00% unsecured senior notes due 2032 ("2.00% Unsecured Senior
Notes") and $850.0 million of 3.00% unsecured senior notes due 2051. The
proceeds from our 2.00% Unsecured Senior Notes are expected to be allocated to
eligible green projects and were initially used to refinance $650.0 million of
our 4.00% unsecured senior notes payable due in 2024, pursuant to a partial cash
tender offer completed on February 10, 2021, and a subsequent call for
redemption for the remaining outstanding amounts that settled on March 12, 2021.

                                      127
--------------------------------------------------------------------------------

Proactive management of transition away from LIBOR



LIBOR has been used extensively in the U.S. and globally as a reference rate for
various commercial and financial contracts, including variable-rate debt and
interest rate swap contracts. However, based on an announcement made by the
Financial Conduct Authority ("FCA") on March 5, 2021, one-week and two-month
LIBOR rates ceased to be published after December 31, 2021, and all other LIBOR
settings will effectively cease after June 30, 2023, and it is expected that
LIBOR will no longer be used after this date. In addition, it is expected that
LIBOR will no longer be used in new contracts entered into after December 31,
2021. To address the impending discontinuation of LIBOR, in the U.S. the
Alternative Reference Rates Committee ("ARRC") was established to help ensure
the successful transition from LIBOR. In June 2017, the ARRC selected SOFR, a
new index calculated by reference to short-term repurchase agreements backed by
U.S. Treasury securities, as its preferred replacement for U.S. dollar LIBOR. We
have been closely monitoring developments related to the transition away from
LIBOR and have implemented numerous proactive measures to minimize the potential
impact of the transition to the Company, specifically:

•We have proactively eliminated outstanding LIBOR-based borrowings under our
unsecured senior bank term loans and secured construction loans through
repayments. From January 2017 through December 2021, we retired approximately
$1.5 billion of all such debt.
•During 2020, we increased the aggregate amount of our commercial paper program
to $1.5 billion from $750.0 million. This program provides us with ability to
issue commercial paper notes bearing interest at short-term fixed rates, with a
maturity of generally 30 days or less and with a maximum maturity of 397 days
from the date of issuance. Our commercial paper program is not subject to LIBOR
and is used for funding short-term working capital needs. As of December 31,
2021, we had an aggregate of $270.0 million of notes outstanding under our
commercial paper program.
•We continue to prudently manage outstanding borrowings under our unsecured
senior line of credit. As of December 31, 2021, we had no borrowings outstanding
under our unsecured senior line of credit. Additionally, new loans that we've
entered into recently are SOFR-based rather than LIBOR-based. Our consolidated
real estate joint venture at 99 Coolidge Avenue holds a SOFR-based construction
loan with an outstanding balance of $8.0 million. In addition, two of our
unconsolidated real estate joint ventures at 1450 Research Boulevard and 101
West Dickman Street each hold a SOFR-based construction loan. As of December 31,
2021, 1450 Research Boulevard had no outstanding balance on its construction
loan and 101 West Dickman Street had an outstanding balance of $9.9 million.
•Our unsecured senior line of credit contains fallback language generally
consistent with the ARRC's Amendment Approach, which provides a streamlined
amendment approach for negotiating a benchmark replacement.
•We continue to monitor developments by the FCA, the ARRC, and other governing
bodies involved in LIBOR transition.

Refer to Note 10 - "Secured and unsecured senior debt" and Note 4 -
"Consolidated and unconsolidated real estate joint ventures" to our consolidated
financial statements under Item 15 and "Item 1A. Risk factors" in this annual
report on Form 10-K for additional information about our management of risks
related to the transition away from LIBOR.

Real estate dispositions and partial interest sales



We expect to continue the disciplined execution of select sales of operating
assets. Future sales will provide an important source of capital to fund a
portion of pending and recently completed opportunistic acquisitions and our
highly leased value-creation development and redevelopment projects, and also
provide significant capital for growth. We may also consider additional sales of
partial interests in core Class A properties and/or development projects. For
2022, we expect real estate dispositions and partial interest sales ranging from
$1.3 billion to $2.1 billion. The amount of asset sales necessary to meet our
forecasted sources of capital will vary depending upon the amount of EBITDA
associated with the assets sold.

During the year ended December 31, 2021, we completed dispositions for an aggregate sales price $2.6 billion. Refer to the "Dispositions and sales of partial interests" section of "Investments in real estate" under Item 7 for additional information on these transactions.



As a REIT, we are generally subject to a 100% tax on the net income from real
estate asset sales that the IRS characterizes as "prohibited transactions." We
do not expect our sales will be categorized as prohibited transactions. However,
unless we meet certain "safe harbor" requirements, whether a real estate asset
sale is a prohibited transaction will be based on the facts and circumstances of
the sale. Our real estate asset sales may not always meet such safe harbor
requirements. Refer to "Item 1A. Risk factors" in this annual report on Form
10-K for additional information about the "prohibited transaction" tax.

                                      128
--------------------------------------------------------------------------------

Common equity transactions



During the year ended December 31, 2021, we completed issuances and executed
forward equity sales agreements for an aggregate 20.8 million shares of common
stock, including the exercise of underwriters' option, for an aggregate net
proceeds of approximately $3.5 billion, as follows:

•In January 2021 and June 2021, we entered into forward equity sales agreements
aggregating $1.1 billion and $1.5 billion, respectively, to sell an aggregate of
6.9 million and 8.1 million of our common stock, respectively, including the
exercise of underwriters' options, at pubic offering price of $164.00 and
$184.00, respectively, before underwriting discounts and commissions. During
2021, we issued all 15.0 million shares under these forward equity sales
agreements and received net proceeds of $2.5 billion.

•In March 2021, we issued the remaining 362 thousand shares of common stock to
settle our forward equity sales agreements that were outstanding as of December
31, 2020, and received net proceeds of $56.2 million.

•In February 2021, we entered into a new ATM common stock offering program,
which allowed us to sell up to an aggregate of $1.0 billion of our common stock.
•We issued 5.5 million shares under our ATM program and received net proceeds of
$984.6 million.
•As of December 31, 2021, we have no amounts remaining under this ATM program.

•In December 2021, we entered into a new ATM common stock offering program,
which allows us to sell up to an aggregate of $1.0 billion of our common stock.
As of December 31, 2021, the full amount remains available for future sales of
our common stock.

In January 2022, we entered into forward equity sales agreements to sell 8.1 million shares of our common stock (including the exercise of underwriters' option) aggregating $1.7 billion at a public offering price of $210.00 per share, before underwriting discounts and commissions.

Other sources



Under our current shelf registration statement filed with the SEC, we may offer
common stock, preferred stock, debt, and other securities. These securities may
be issued, from time to time, at our discretion based on our needs and market
conditions, including, as necessary, to balance our use of incremental debt
capital.

Additionally, we hold interests, together with joint venture partners, in real
estate joint ventures that we consolidate in our financial statements. These
joint venture partners may contribute equity into these entities primarily
related to their share of funds for construction and financing-related
activities. During the year ended December 31, 2021, we received $2.0 billion of
contributions from and sales of noncontrolling interests.

                                      129
--------------------------------------------------------------------------------

Uses of capital

Summary of capital expenditures



One of our primary uses of capital relates to the development, redevelopment,
pre-construction, and construction of properties. We currently have projects in
our growth pipeline aggregating 4.8 million RSF of Class A office/laboratory,
agtech, and technology office space undergoing construction, 8.7 million RSF of
near-term and intermediate-term development and redevelopment projects, and
14.7 million SF of future development projects in North America. We incur
capitalized construction costs related to development, redevelopment,
pre-construction, and other construction activities. We also incur additional
capitalized project costs, including interest, property taxes, insurance, and
other costs directly related and essential to the development, redevelopment,
pre-construction, or construction of a project, during periods when activities
necessary to prepare an asset for its intended use are in progress. Refer to the
"New Class A development and redevelopment properties: current projects" and
"Summary of capital expenditures" subsections of the "Investments in real
estate" section under Item 2 in this annual report on Form 10-K for more
information on our capital expenditures.

We capitalize interest cost as a cost of the project only during the period in
which activities necessary to prepare an asset for its intended use are ongoing,
provided that expenditures for the asset have been made and interest cost has
been incurred. Capitalized interest for the years ended December 31, 2021 and
2020 of $170.6 million and $125.6 million, respectively, was classified in
investments in real estate.

Property taxes, insurance on real estate, and indirect project costs, such as
construction administration, legal fees, and office costs that clearly relate to
projects under development or construction, are capitalized as incurred during
the period an asset is undergoing activities to prepare it for its intended use.
We capitalized payroll and other indirect costs related to development,
redevelopment, pre-construction, and construction projects, aggregating $69.8
million and $61.0 million, and property taxes, insurance on real estate and
other operating costs aggregating $73.8 million and $52.6 million during the
years ended December 31, 2021 and 2020, respectively.

The increase in capitalized costs for the year ended December 31, 2021, compared
to the same period in 2020 was primarily due to an increase in our
value-creation pipeline projects undergoing construction and pre-construction
activities in 2021 over 2020. Pre-construction activities include entitlements,
permitting, design, site work, and other activities preceding commencement of
construction of aboveground building improvements. The advancement of
pre-construction efforts is focused on reducing the time required to deliver
projects to prospective tenants. These critical activities add significant value
for future ground-up development and are required for the vertical construction
of buildings. Should we cease activities necessary to prepare an asset for its
intended use, the interest, taxes, insurance, and certain other direct and
indirect project costs related to the asset would be expensed as incurred.
Expenditures for repairs and maintenance are expensed as incurred.

Fluctuations in our development, redevelopment, and construction activities
could result in significant changes to total expenses and net income. For
example, had we experienced a 10% reduction in development, redevelopment, and
construction activities without a corresponding decrease in indirect project
costs, including interest and payroll, total expenses would have increased by
approximately $24.0 million for the year ended December 31, 2021.

We use third-party brokers to assist in our leasing activity, who are paid on a
contingent basis upon successful leasing. We are required to capitalize initial
direct costs related to successful leasing transactions that result directly
from and are essential to the lease transaction and would not have been incurred
had that lease transaction not been successfully executed. During the year ended
December 31, 2021, we capitalized total initial direct leasing costs of $189.3
million. Costs that we incur to negotiate or arrange a lease regardless of its
outcome, such as fixed employee compensation, tax, or legal advice to negotiate
lease terms, and other costs, are expensed as incurred.

Acquisitions



Refer to the "Acquisitions" section in Note 3 - "Investments in real estate" and
to Note 4 - "Consolidated and unconsolidated real estate joint ventures" to our
consolidated financial statements under Item 15 in this annual report on Form
10-K, and the "Acquisitions" subsection of the "Investments in real estate"
section in "Item 2. Properties" in this annual report on Form 10-K for
information on our acquisitions.

Dividends



During the years ended December 31, 2021 and 2020, we paid common stock
dividends of $656.0 million and $533.0 million, respectively. The increase of
$123.0 million in dividends paid on our common stock during the year ended
December 31, 2021, compared to the year ended December 31, 2020, was primarily
due to an increase in number of common shares outstanding subsequent to
January 1, 2020 as a result of issuances of common stock under our ATM program
and settlement of forward equity sales agreements, and partially due to the
increase in the related dividends to $4.42 per common share paid during the year
ended December 31, 2021 from $4.18 per common share paid during the year ended
December 31, 2020.

                                      130
--------------------------------------------------------------------------------

Secured notes payable



Secured notes payable as of December 31, 2021 consisted of four notes secured by
eight properties. Our secured notes payable typically require monthly payments
of principal and interest and had a weighted-average interest rate of
approximately 3.40%. As of December 31, 2021, the total book value of our
investments in real estate securing debt was approximately $936.0 million. As of
December 31, 2021, our secured notes payable, including unamortized discounts
and deferred financing costs, comprised approximately $195.2 million and $10.0
million of fixed-rate debt and unhedged variable-debt, respectively.
Unsecured senior notes payable and unsecured senior line of credit

The requirements of, and our actual performance with respect to, the key financial covenants under our unsecured senior notes payable as of December 31, 2021 were as follows:


            Covenant Ratios(1)                              Requirement                           December 31, 2021
Total Debt to Total Assets                       Less than or equal to 60%                               28%
Secured Debt to Total Assets                     Less than or equal to 40%                               1%

Consolidated EBITDA(2) to Interest Expense Greater than or equal to 1.5x

                          11.4x
Unencumbered Total Asset Value to
Unsecured Debt                                   Greater than or equal to 150%                          343%


(1)All covenant ratio titles utilize terms as defined in the respective debt
agreements.
(2)The calculation of consolidated EBITDA is based on the definitions contained
in our loan agreements and is not directly comparable to the computation of
EBITDA as described in Exchange Act Release No. 47226.

In addition, the terms of the indentures, among other things, limit the ability
of the Company, Alexandria Real Estate Equities, L.P., and the Company's
subsidiaries to (i) consummate a merger, or consolidate or sell all or
substantially all of the Company's assets, and (ii) incur certain secured or
unsecured indebtedness.

The requirements of, and our actual performance with respect to, the key financial covenants under our unsecured senior line of credit as of December 31, 2021 were as follows:


           Covenant Ratios (1)                          Requirement                          December 31, 2021
Leverage Ratio                                  Less than or equal to 60.0%                  26.7%
Secured Debt Ratio                              Less than or equal to 45.0%                   0.6%
                                                Greater than or equal to
Fixed-Charge Coverage Ratio                     1.50x                                        4.51x
                                                Greater than or equal to
Unsecured Interest Coverage Ratio               1.75x                                        9.16x


(1)All covenant ratio titles utilize terms as defined in the credit agreement.

Estimated interest payments



Estimated interest payments on our fixed-rate debt were calculated based upon
contractual interest rates, including interest payment dates and scheduled
maturity dates. As of December 31, 2021, 97% of our debt was fixed-rate debt.
For additional information regarding our debt, refer to Note 10 - "Secured and
unsecured senior debt" to our consolidated financial statements under Item 15 in
this annual report on Form 10-K.

Ground lease obligations

Operating lease agreements



Ground lease obligations as of December 31, 2021, included leases for 39 of our
properties, which accounted for approximately 9% of our total number of
properties. Excluding one ground lease that expires in 2036 related to one
operating property with a net book value of $6.9 million as of December 31,
2021, our ground lease obligations have remaining lease terms ranging from
approximately 32 to 93 years, including available extension options that we are
reasonably certain to exercise.

                                      131
--------------------------------------------------------------------------------

As of December 31, 2021, the remaining contractual payments under ground and
office lease agreements in which we are the lessee aggregated $927.9 million and
$25.4 million, respectively. We are required to recognize a right-of-use asset
and a related liability to account for our future obligations under operating
lease arrangements in which we are the lessee. The operating lease liability is
measured based on the present value of the remaining lease payments, including
payments during the term under our extension options that we are reasonably
certain to exercise. The right-of-use asset is equal to the corresponding
operating lease liability, adjusted for the initial direct leasing cost and any
other consideration exchanged with the landlord prior to the commencement of the
lease, as well as adjustments to reflect favorable or unfavorable terms of an
acquired lease when compared with market terms at the time of acquisition. As of
December 31, 2021, the present value of the remaining contractual payments,
aggregating $953.3 million, under our operating lease agreements, including our
extension options that we are reasonably certain to exercise, was $434.7
million, which was classified in accounts payable, accrued expenses, and other
liabilities in our consolidated balance sheets. As of December 31, 2021, the
weighted-average remaining lease term of operating leases in which we are the
lessee was approximately 42 years, and the weighted-average discount rate was
4.57%. Our corresponding operating lease right-of-use assets, adjusted for
initial direct leasing costs and other consideration exchanged with the landlord
prior to the commencement of the lease, aggregated $474.3 million. We classify
the right-of-use asset in other assets in our consolidated balance sheets. Refer
to the "Lease accounting" section in Note 2 - "Summary of significant accounting
policies" to our consolidated financial statements under Item 15 in this annual
report on Form 10-K for additional information.

Commitments



As of December 31, 2021, remaining aggregate costs under contract for the
construction of properties undergoing development, redevelopment, and
improvements under the terms of leases approximated $2.8 billion. We expect
payments for these obligations to occur over one to three years, subject to
capital planning adjustments from time to time. We may have the ability to cease
the construction of certain properties, which would result in the reduction of
our commitments. In addition, we have letters of credit and performance
obligations aggregating $106.8 million primarily related to deposits for
acquisitions in our Greater Boston and San Francisco Bay Area markets, including
one $77.5 million letter of credit we issued during the three months ended
June 30, 2021. The $77.5 million letter of credit served to secure our
performance under the purchase and sale agreement of our acquisition of One
Rogers Street in our Cambridge/Inner Suburbs submarket for a purchase price of
$849.4 million. We completed this acquisition in December 2021 and terminated
the letter of credit in January 2022.

We are committed to funding approximately $391.0 million related to our non-real
estate investments. These funding commitments are primarily associated with our
investments in privately held entities that report NAV, which expire at various
dates over the next 11 years, with a weighted-average expiration of 9.0 years as
of December 31, 2021.

Exposure to environmental liabilities



In connection with the acquisition of all of our properties, we have obtained
Phase I environmental assessments to ascertain the existence of any
environmental liabilities or other issues. The Phase I environmental assessments
of our properties have not revealed any environmental liabilities that we
believe would have a material adverse effect on our financial condition or
results of operations taken as a whole, nor are we aware of any material
environmental liabilities that have occurred since the Phase I environmental
assessments were completed. In addition, we carry a policy of pollution legal
liability insurance covering exposure to certain environmental losses at
substantially all of our properties.

Foreign currency translation gains and losses



The following table presents the change in accumulated other comprehensive loss
attributable to Alexandria Real Estate Equities, Inc.'s stockholders during the
year ended December 31, 2021, due to the changes in the foreign exchange rates
for our real estate investments in Canada and Asia. We reclassify unrealized
foreign currency translation gains and losses into net income (loss) as we
dispose of these holdings.
(In thousands)                                             Total
Balance as of December 31, 2020                          $ (6,625)

Other comprehensive loss before reclassifications            (669)
Net other comprehensive loss                                 (669)

Balance as of December 31, 2021                          $ (7,294)



                                      132
--------------------------------------------------------------------------------

Issuer and guarantor subsidiary summarized financial information

Alexandria Real Estate Equities, Inc. (the "Issuer") has sold certain debt
securities registered under the Securities Act of 1933, as amended, that are
fully and unconditionally guaranteed by Alexandria Real Estate Equities, L.P.
(the "LP" or the "Guarantor Subsidiary"), an indirectly 100% owned subsidiary of
the Issuer. The Issuer's other subsidiaries, including, but not limited to, the
subsidiaries that own substantially all of its real estate (collectively, the
"Combined Non-Guarantor Subsidiaries"), will not provide a guarantee of such
securities, including the subsidiaries that are partially or 100% owned by the
LP. The following summarized financial information presents on a combined basis
for the Issuer and the Guarantor Subsidiary balance sheet financial information
as of December 31, 2021 and 2020, and results of operations and comprehensive
income for the years ended December 31, 2021 and 2020. The information presented
below excludes eliminations necessary to arrive at the information on a
consolidated basis. In presenting the summarized financial statements, the
equity method of accounting has been applied to (i) the Issuer's interests in
the Guarantor Subsidiary, (ii) the Guarantor Subsidiary's interests in the
Combined Non-Guarantor Subsidiaries, and (iii) the Combined Non-Guarantor
Subsidiaries' interests in the Guarantor Subsidiary, where applicable, even
though all such subsidiaries meet the requirements to be consolidated under
GAAP. All assets and liabilities have been allocated to the Issuer and the
Guarantor Subsidiary generally based on legal entity ownership.

The following tables present combined summarized financial information as of
December 31, 2021 and 2020, and for the years ended December 31, 2021 and 2020,
for the Issuer and Guarantor Subsidiary. Amounts provided do not represent our
total consolidated amounts (in thousands):

                                                                       December 31,
                                                                  2021             2020
  Assets:
  Cash, cash equivalents, and restricted cash                 $    78,856      $   404,802
  Other assets                                                    101,956          100,689
  Total assets                                                $   180,812      $   505,491

  Liabilities:
  Unsecured senior notes payable                              $ 8,316,678      $ 7,232,370
  Unsecured senior line of credit and commercial paper            269,990           99,991
  Other liabilities                                               401,721          341,621
  Total liabilities                                           $ 8,988,389      $ 7,673,982



                                                                       Year Ended December 31,
                                                                      2021                  2020
Total revenues                                                  $      26,798          $    22,946
Total expenses                                                       (363,525)            (355,370)
Net loss                                                             (336,727)            (332,424)

Net income attributable to unvested restricted stock awards

                                                                 (7,848)             (10,168)

Net loss attributable to Alexandria Real Estate Equities, Inc.'s common stockholders

                                      $    

(344,575) $ (342,592)





As of December 31, 2021, 401 of our 414 properties were held indirectly by the
REIT's wholly owned consolidated subsidiary, Alexandria Real Estate Equities,
LP.
                                      133
--------------------------------------------------------------------------------

Critical accounting estimates



Our consolidated financial statements have been prepared in accordance with
GAAP. The preparation of these financial statements in conformity with GAAP
requires us to make estimates, judgments, and assumptions that affect the
reported amounts of assets, liabilities, revenues, and expenses. We base these
estimates, judgments, and assumptions on historical experience, current trends,
and various other factors that we believe to be reasonable under the
circumstances.

We continually evaluate the estimates, judgments, and assumptions we use to
prepare our consolidated financial statements. Changes in estimates, judgments,
or assumptions could affect our financial position and our results of
operations, which are used by our stockholders, potential investors, industry
analysts, and lenders in their evaluation of our performance.

Our critical accounting estimates are defined as accounting estimates or
assumptions made in accordance with GAAP, which involve a significant level of
estimation uncertainty or subjectivity and have had or are reasonably likely to
have a material impact on our financial condition or results of operations. Our
significant accounting policies, which utilize these critical accounting
estimates, are described in Note 2 - "Summary of significant accounting
policies" to our consolidated financial statements under Item 15 in this annual
report on Form 10-K. Our critical accounting estimates are described below.

Recognition of real estate acquired



Generally, our acquisitions of real estate or in-substance real estate are
accounted for as asset acquisitions and not business combinations because
substantially all of the fair value is concentrated in a single identifiable
asset or group of similar identifiable assets (i.e., land, buildings, and
related intangible assets). The accounting model for asset acquisitions requires
that the acquisition consideration (including acquisition costs) be allocated to
the individual assets acquired and liabilities assumed on a relative fair value
basis. Any excess (deficit) of the consideration transferred relative to the sum
of the fair value of the assets acquired and liabilities assumed is allocated to
the individual assets and liabilities based on their relative fair values.

We assess the relative fair values of tangible and intangible assets and liabilities based on:



(i)Available comparable market information,
(ii)Estimated replacement costs, or
(iii)Discounted cash flow analysis/estimated net operating income and
capitalization rates.

In certain instances, we may use multiple valuation techniques and estimate fair
value based on an average of multiple valuation results. We exercise judgement
to determine key assumptions used in each valuation technique. For example, to
estimate future cash flows in the discounted cash flow analysis, we are required
to use judgment and make a number of assumptions, including those related to
projected growth in rental rates and operating expenses, and anticipated trends
and market/economic conditions. The use of different assumptions in the
discounted cash flow analysis can affect the amount of consideration allocated
to the acquired depreciable/amortizable asset, which in turn can impact our net
income due to the recognition of the related depreciation/amortization expense
in our consolidated statements of operations.

We completed acquisitions of 87 properties for a total purchase price of $5.5
billion during the year ended December 31, 2021. These transactions were
accounted for as asset acquisitions, and the purchase price of each was
allocated based on the relative fair value of the asset acquired and liabilities
assumed. Refer to the "Investments in real estate" section of Note 2 - "Summary
of significant accounting policies" to our consolidated financial statements
under Item 15 in this annual report on Form 10-K for additional information.

Impairment of long-lived assets

Impairment of real estate assets classified as held for sale



A property is classified as held for sale when all of the accounting criteria
for a plan of sale have been met. These criteria are described in the
"Investments in real estate" section of Note 2 - "Summary of significant
accounting policies" to our consolidated financial statements under Item 15 in
this annual report on Form 10-K. Upon classification as held for sale, we
recognize an impairment charge, if necessary, to lower the carrying amount of
the real estate asset to its estimated fair value less cost to sell. The
determination of fair value can involve significant judgments and assumptions.
We develop key assumptions based on the following available factors: (i)
contractual sales price, (ii) preliminary non-binding letters of intent, or
(iii) other available comparable market information. If this information is not
available, we use estimated replacement costs or estimated cash flow projections
that utilize estimated discount and capitalization rates. These estimates are
subject to uncertainty and therefore require significant judgment by us. We
review all assets held for sale each reporting period to determine whether the
existing carrying amounts are fully recoverable in comparison to their estimated
fair values less costs to sell. Subsequently, as a result of our quarterly
assessment, we may recognize an incremental impairment charge for any decrease
in the asset's fair value less cost to sell. Conversely, we may recognize a gain
for a subsequent increase in fair value less cost to sell, limited to the
cumulative net loss previously recognized.

                                      134
--------------------------------------------------------------------------------

Impairment of other long-lived assets



For each reporting period, we review current activities and changes in the
business conditions of all of our long-lived assets, including our rental
properties, CIP, land held for development, right-of-use assets related to
operating leases in which we are the lessee, and intangibles, to determine the
existence of any triggering events or impairment indicators requiring an
impairment analysis. If triggering events or impairment indicators are
identified, we review an estimate of the future undiscounted cash flows,
including, if necessary, a probability-weighted approach if multiple outcomes
are under consideration.

Long-lived assets to be held and used, are individually evaluated for impairment
when conditions exist that may indicate that the carrying amount of a long-lived
asset may not be recoverable. The carrying amount of a long-lived asset to be
held and used is not recoverable if it exceeds the sum of the undiscounted cash
flows expected to result from the use and eventual disposition of the asset.
Triggering events or impairment indicators for long-lived assets to be held and
used, including our rental properties, CIP, land held for development, and
intangibles, are assessed by project and include significant fluctuations in
estimated net operating income, occupancy changes, significant near-term lease
expirations, current and historical operating and/or cash flow losses,
construction costs, estimated completion dates, rental rates, and other market
factors. We assess the expected undiscounted cash flows based upon numerous
factors, including, but not limited to, construction costs, available market
information, current and historical operating results, known trends, current
market/economic conditions that may affect the property, and our assumptions
about the use of the asset, including, if necessary, a probability-weighted
approach if multiple outcomes are under consideration.

Upon determination that an impairment has occurred, a write-down is recognized
to reduce the carrying amount to its estimated fair value. If an impairment loss
is not required to be recognized, the recognition of depreciation or
amortization is adjusted prospectively, as necessary, to reduce the carrying
amount of the real estate to its estimated disposition value over the remaining
period that the asset is expected to be held and used. We may also adjust
depreciation of properties that are expected to be disposed of or redeveloped
prior to the end of their useful lives.

The evaluation for impairment and calculation of the carrying amount of a long-lived asset to be held and used involves consideration of factors and calculations that are different than the estimate of fair value of assets classified as held for sale. Because of these two different models, it is possible for a long-lived asset previously classified as held and used to require the recognition of an impairment charge upon classification as held for sale.

Impairment of real estate joint ventures accounted for under the equity method of accounting



We generally account for our investments in real estate joint ventures that do
not meet the consolidation criteria under the equity method. Under the equity
method of accounting, we initially recognize our investment at cost and
subsequently adjust the carrying amount of the investment for our share of the
investee's earnings or losses, distributions received, and other-than-temporary
impairments.

Our unconsolidated real estate joint ventures are individually evaluated for
impairment when conditions exist that may indicate that the decrease in the
carrying amount of our investment has occurred and is other than temporary.
Triggering events or impairment indicators for an unconsolidated joint venture
include its recurring operating losses, and other events such as occupancy
changes, significant near-term lease expirations, significant changes in
construction costs, estimated completion dates, rental rates, and other factors
related to the properties owned by the real estate joint venture, or a decision
by investors to cease providing support or reduce their financial commitment to
the joint venture.

Upon determination that an other-than-temporary impairment has occurred, a
write-down is recognized to reduce the carrying amount of investment to its
estimated fair value. As of December 31, 2021, the carrying amounts of our
investments in unconsolidated real estate joint ventures aggregated
$38.5 million, or approximately 0.1% of our total assets. During the year ended
December 31, 2021, no other-than-temporary impairments related to our
unconsolidated real estate joint ventures were identified. Refer to the
"Unconsolidated real estate joint ventures" section within Note 4 -
"Consolidated and unconsolidated real estate joint ventures" to our consolidated
financial statements under Item 15 in this annual report on Form 10-K for the
information regarding the impairment recognized during the year ended December
31, 2020, in connection with the retail shopping center located in our Rockville
submarket of Maryland owned by our 1401/1413 Research Boulevard unconsolidated
real estate joint venture.

Impairment of non-real estate investments



We hold investments in publicly traded companies and privately held entities
primarily involved in the life science, agtech, and technology industries. As a
REIT, we generally limit our ownership percentage in the voting stock of each
individual entity to less than 10%.

Our investments in privately held entities that do not report NAV per share
require our evaluation for impairment when changes in these entities' conditions
may indicate that an impairment exists. We closely monitor these investments
throughout the year for new developments, including operating results, prospects
and results of clinical trials, new product initiatives, new collaborative
agreements, capital-raising events, and merger and acquisition activities. We
evaluate these investees on the basis of a qualitative assessment for
                                      135
--------------------------------------------------------------------------------

indicators of impairment by monitoring the presence of the following triggering
events or impairment indicators: (i) a significant deterioration in the earnings
performance, asset quality, or business prospects of the investee; (ii) a
significant adverse change in the regulatory, economic, or technological
environment of the investee, (iii) a significant adverse change in the general
market condition, including the research and development of technology and
products that the investee is bringing or attempting to bring to the market, or
(iv) significant concerns about the investee's ability to continue as a going
concern. If such indicators are present, we are required to estimate the
investment's fair value and immediately recognize an impairment loss in an
amount equal to the investment's carrying value in excess of its estimated fair
value. As of each December 31, 2021, 2020, and 2019, the carrying amounts of our
investments in privately held entities that do not report NAV per share
accounted for approximately 2% of our total assets and aggregated
$491.3 million, $389.2 million, and $388.1 million, respectively. During the
years ended December 31, 2021, 2020, and 2019, we recognized impairment charges
aggregating 0%, 6%, and 4% of the carrying amounts of our investments in
privately held entities that do not report NAV, respectively.

Monitoring of tenant credit quality



We monitor, on an ongoing basis, the credit quality and any related material
changes of our tenants by (i) monitoring the credit rating of tenants that are
rated by a nationally recognized credit rating agency, (ii) reviewing financial
statements of the tenants that are publicly available or that are required to be
delivered to us pursuant to the applicable lease, (iii) monitoring news reports
regarding our tenants and their respective businesses and industries in which
they conduct business, and (iv) monitoring the timeliness of lease payments.

We have a team of employees who, among them, have an extensive educational
background or experience in biology, chemistry, industrial biotechnology,
agtech, and the life science industry, as well as knowledge in finance. This
team is responsible for timely assessment, monitoring, and communication of our
tenants' credit quality and any material changes therein. During the fiscal
years ended 2021, 2020, and 2019, specific write-offs and a general allowance
related to deferred rent balances of tenants recognized in our consolidated
statements of operations have not exceeded 0.3% of our income from rentals for
each respective year. Our general allowance was $6.8 million as of December 31,
2021.

Allowance for credit losses

For the financial assets in scope of the accounting standard on credit losses,
we are required to estimate and recognize lifetime expected losses, rather than
incurred losses, which results in the earlier recognition of credit losses even
if the expected risk of credit loss is remote.

As of December 31, 2021, all of our 414 properties were subject to the operating
lease agreements, which are excluded from the scope of the standard on credit
losses. As of December 31, 2021, we had one direct financing lease agreement for
a parking structure and two sales-type ground leases subject to this standard,
with an aggregate net investment balance of $70.7 million, which represented
approximately 0.2% of our total assets. At each reporting date, we estimate the
current credit loss related to these assets by assessing the probability of
default on these leases based on the lessees' financial condition, credit
rating, business prospects, remaining lease term, and, in the case of the direct
financing lease, the expected value of the underlying collateral upon its
repossession, and, if necessary, we recognize a credit loss adjustment. Since
the adoption of this standard on January 1, 2020, and as of each December 31,
2021 and 2020, our allowance for credit losses has not exceeded $2.8 million, or
0.01% of our total assets. For further details, refer to refer to the "Allowance
for credit losses" section in Note 2 - "Summary of significant accounting
policies" and to Note 5 - "Leases" to our consolidated financial statements.

                                      136
--------------------------------------------------------------------------------

Non-GAAP measures and definitions

This section contains additional information of certain non-GAAP financial measures and the reasons why we use these supplemental measures of performance and believe they provide useful information to investors, as well as the definitions of other terms used in this annual report on Form 10-K.

Funds from operations and funds from operations, as adjusted, attributable to Alexandria Real Estate Equities, Inc.'s common stockholders



GAAP-basis accounting for real estate assets utilizes historical cost accounting
and assumes that real estate values diminish over time. In an effort to overcome
the difference between real estate values and historical cost accounting for
real estate assets, the Nareit Board of Governors established funds from
operations as an improved measurement tool. Since its introduction, funds from
operations has become a widely used non-GAAP financial measure among equity
REITs. We believe that funds from operations is helpful to investors as an
additional measure of the performance of an equity REIT. Moreover, we believe
that funds from operations, as adjusted, allows investors to compare our
performance to the performance of other real estate companies on a consistent
basis, without having to account for differences recognized because of real
estate acquisition and disposition decisions, financing decisions, capital
structure, capital market transactions, variances resulting from the volatility
of market conditions outside of our control, or other corporate activities that
may not be representative of the operating performance of our properties.

The 2018 White Paper published by the Nareit Board of Governors (the "Nareit
White Paper") defines funds from operations as net income (computed in
accordance with GAAP), excluding gains or losses on sales of real estate, and
impairments of real estate, plus depreciation and amortization of operating real
estate assets, and after adjustments for our share of consolidated and
unconsolidated partnerships and real estate joint ventures. Impairments
represent the write-down of assets when fair value over the recoverability
period is less than the carrying value due to changes in general market
conditions and do not necessarily reflect the operating performance of the
properties during the corresponding period.

We compute funds from operations, as adjusted, as funds from operations
calculated in accordance with the Nareit White Paper, excluding significant
gains, losses, and impairments realized on non-real estate investments,
unrealized gains or losses on non-real estate investments, gains or losses on
early extinguishment of debt, significant termination fees, acceleration of
stock compensation expense due to the resignation of an executive officer, deal
costs, the income tax effect related to such items, and the amount of such items
that is allocable to our unvested restricted stock awards. Neither funds from
operations nor funds from operations, as adjusted, should be considered as
alternatives to net income (determined in accordance with GAAP) as indications
of financial performance, or to cash flows from operating activities (determined
in accordance with GAAP) as measures of liquidity, nor are they indicative of
the availability of funds for our cash needs, including our ability to make
distributions.

The following table reconciles net income to funds from operations for the share
of consolidated real estate joint ventures attributable to noncontrolling
interests and our share of unconsolidated real estate joint ventures for the
three and twelve months ended December 31, 2021 (in thousands):
                                 Noncontrolling Interest Share of                    Our Share of Unconsolidated
                             Consolidated Real Estate Joint Ventures                 Real Estate Joint Ventures
                                        December 31, 2021                                 December 31, 2021
                                                                                Three Months
                            Three Months Ended           Year Ended                 Ended                Year Ended
Net income                 $          24,901          $       83,035          $        3,018          $       12,255
Depreciation and
amortization                          21,265                  70,880                   3,058                  13,734
Funds from operations      $          46,166          $      153,915          $        6,076          $       25,989







                                      137

--------------------------------------------------------------------------------

The following tables present a reconciliation of net income attributable to
Alexandria Real Estate Equities, Inc.'s common stockholders, the most directly
comparable financial measure presented in accordance with GAAP, including our
share of amounts from consolidated and unconsolidated real estate joint
ventures, to funds from operations attributable to Alexandria Real Estate
Equities, Inc.'s common stockholders - diluted, and funds from operations
attributable to Alexandria Real Estate Equities, Inc.'s common stockholders -
diluted, as adjusted, and the related per share amounts for the years ended
December 31, 2021, 2020, and 2019. Per share amounts may not add due to
rounding.
                                                                       Year Ended December 31,
(In thousands)                                               2021                2020                2019
Net income attributable to Alexandria Real Estate
Equities, Inc.'s common stockholders - basic and
diluted                                                 $   563,399          $  760,791          $ 350,995
Depreciation and amortization of real estate assets         804,633             684,682            541,855

Noncontrolling share of depreciation and amortization from consolidated real estate JVs

                           (70,880)            (61,933)           (30,960)
Our share of depreciation and amortization from
unconsolidated real estate JVs                               13,734              11,413              6,366
Gain on sales of real estate                               (126,570)   (1)     (154,089)              (474)
Impairment of real estate - rental properties                25,485              40,501             12,334
Assumed conversion of 7.00% Series D cumulative
convertible preferred stock                                       -                   -              3,204
Allocation to unvested restricted stock awards               (6,315)             (7,018)            (5,904)

Funds from operations attributable to Alexandria Real Estate Equities, Inc.'s common stockholders - diluted(2)

                                                1,203,486           1,274,347            877,416
Unrealized gains on non-real estate investments             (43,632)           (374,033)          (161,489)
Significant realized gains on non-real estate
investments                                                (110,119)                  -                  -
Impairment of real estate                                    27,190              15,221                  -
Impairment of non-real estate investments                         -              24,482             17,124
Loss on early extinguishment of debt                         67,253              60,668             47,570
Loss on early termination of interest rate hedge
agreements                                                        -                   -              1,702
Termination fee                                                   -             (86,179)                 -
Acceleration of stock compensation expense due to
executive officer resignation                                     -               4,499                  -
Preferred stock redemption charge                                 -                   -              2,580
Removal of assumed conversion of 7.00% Series D
cumulative convertible preferred stock                            -                   -             (3,204)
Allocation to unvested restricted stock awards                  710               4,790              1,307

Funds from operations attributable to Alexandria Real Estate Equities, Inc.'s common stockholders - diluted, as adjusted

$ 1,144,888          $  923,795          $ 783,006



(1)Includes $101.1 million related to the sale of our entire 49.0% interest in
the unconsolidated real estate joint venture at Menlo Gateway.
(2)Calculated in accordance with standards established by the Nareit Board of
Governors.



                                      138

--------------------------------------------------------------------------------

                                                                              Year Ended December 31,
(Per share)                                                          2021                 2020               2019

Net income per share attributable to Alexandria Real Estate Equities, Inc.'s common stockholders - diluted $ 3.82

$    6.01          $    3.12
Depreciation and amortization of real estate assets                 5.07                   5.01               4.60
Gain on sales of real estate                                       (0.86)                 (1.22)                 -
Impairment of real estate - rental properties                       0.17                   0.32               0.11
Allocation to unvested restricted stock awards                     (0.04)                 (0.05)             (0.06)
Funds from operations per share attributable to
Alexandria Real Estate Equities, Inc.'s common
stockholders - diluted                                              8.16                  10.07               7.77
Unrealized gains on non-real estate investments                    (0.30)                 (2.96)             (1.44)
Significant realized gains on non-real estate
investments                                                        (0.75)                     -                  -
Impairment of real estate                                           0.18                   0.12                  -
Impairment of non-real estate investments                              -                   0.19               0.15
Loss on early extinguishment of debt                                0.46                   0.48               0.42
Loss on early termination of interest rate hedge
agreements                                                             -                      -               0.02
Termination fee                                                        -                  (0.68)                 -
Acceleration of stock compensation expense due to
executive officer resignation                                          -                   0.04                  -
Preferred stock redemption charge                                      -                      -               0.02
Allocation to unvested restricted stock awards                      0.01                   0.04               0.02
Funds from operations per share attributable to
Alexandria Real Estate Equities, Inc.'s common
stockholders - diluted, as adjusted                            $    7.76

$ 7.30 $ 6.96

Weighted-average shares of common stock outstanding(1) for calculations of: EPS - diluted

                                                    147,460                126,490            112,524
Funds from operations - diluted, per share                       147,460                126,490            112,966

Funds from operations - diluted, as adjusted, per share 147,460

             126,490            112,524


(1)Refer to the definition of "Weighted-average shares of common stock outstanding - diluted" within this section of this Item 7 in this annual report on Form 10-K for additional information.


                                      139
--------------------------------------------------------------------------------

Adjusted EBITDA and Adjusted EBITDA margin



We use Adjusted EBITDA as a supplemental performance measure of our operations,
for financial and operational decision-making, and as a supplemental means of
evaluating period-to-period comparisons on a consistent basis. Adjusted EBITDA
is calculated as earnings before interest, taxes, depreciation, and amortization
("EBITDA"), excluding stock compensation expense, gains or losses on early
extinguishment of debt, gains or losses on sales of real estate, impairments of
real estate, and significant termination fees. Adjusted EBITDA also excludes
unrealized gains or losses and significant realized gains or losses and
impairments that result from our non-real estate investments. These non-real
estate investment amounts are classified in our consolidated statements of
operations outside of total revenues.

We believe Adjusted EBITDA provides investors with relevant and useful
information as it allows investors to evaluate the operating performance of our
business activities without having to account for differences recognized because
of investing and financing decisions related to our real estate and non-real
estate investments, our capital structure, capital market transactions, and
variances resulting from the volatility of market conditions outside of our
control. For example, we exclude gains or losses on the early extinguishment of
debt to allow investors to measure our performance independent of our
indebtedness and capital structure. We believe that adjusting for the effects of
impairments and gains or losses on sales of real estate, significant impairments
and realized gains or losses on non-real estate investments, and significant
termination fees allows investors to evaluate performance from period to period
on a consistent basis without having to account for differences recognized
because of investing and financing decisions related to our real estate and
non-real estate investments or other corporate activities that may not be
representative of the operating performance of our properties.

In addition, we believe that excluding charges related to stock compensation and
unrealized gains or losses facilitates for investors a comparison of our
business activities across periods without the volatility resulting from market
forces outside of our control. Adjusted EBITDA has limitations as a measure of
our performance. Adjusted EBITDA does not reflect our historical expenditures or
future requirements for capital expenditures or contractual commitments. While
Adjusted EBITDA is a relevant measure of performance, it does not represent net
income (loss) or cash flows from operations calculated and presented in
accordance with GAAP, and it should not be considered as an alternative to those
indicators in evaluating performance or liquidity.

In order to calculate the Adjusted EBITDA margin, we divide Adjusted EBITDA by
total revenue as presented in our consolidated statements of operations. We
believe this supplemental performance measure provides investors with additional
useful information regarding the profitability of our operating activities.


                                      140
--------------------------------------------------------------------------------

The following table reconciles net income (loss) and revenues, the most directly
comparable financial measures calculated and presented in accordance with GAAP,
to Adjusted EBITDA and calculates the Adjusted EBITDA margin for the three
months and years ended December 31, 2021 and 2020 (dollars in thousands):

                                              Three Months Ended December 31,                 Year Ended December 31,
                                                 2021                   2020                 2021                  2020
Net income                                $         99,796          $  457,133          $    654,282          $   827,171
Interest expense                                    34,862              37,538               142,165              171,609
Income taxes                                         4,156               2,053                12,054                7,230
Depreciation and amortization                      239,254             177,750               821,061              698,104
Stock compensation expense                          14,253              11,394                48,669               43,502
Loss on early extinguishment of
debt                                                     -               7,898                67,253               60,668
Gain on sales of real estate                      (124,226)   (1)     (152,503)             (126,570)            (154,089)
Significant realized gains on
non-real estate investments                              -                   -              (110,119)   (2)             -
Unrealized losses (gains) on
non-real estate investments                        139,716            (233,538)              (43,632)            (374,033)
Impairment of real estate                                -              25,177                52,675               55,722
Impairment of non-real estate
investments                                              -                   -                     -               24,482
Termination fee                                          -                   -                     -              (86,179)
Adjusted EBITDA                           $        407,811          $  332,902          $  1,517,838          $ 1,274,187

Total revenues                            $        576,923          $  463,720          $  2,114,150          $ 1,885,637

Adjusted EBITDA margin                                    71%                 72%                   72%                  68%



(1)Includes $101.1 million related to the sale of our entire 49.0% interest in
the unconsolidated real estate joint venture at Menlo Gateway.
(2)Refer to the "Investments" section within this Item 7 in this annual report
on Form 10-K for additional information.
                                      141
--------------------------------------------------------------------------------

Annual rental revenue



Annual rental revenue represents the annualized fixed base rental obligations,
calculated in accordance with GAAP, for leases in effect as of the end of the
period, related to our operating RSF. Annual rental revenue is presented using
100% of the annual rental revenue of our consolidated properties and our share
of annual rental revenue for our unconsolidated real estate joint ventures.
Annual rental revenue per RSF is computed by dividing annual rental revenue by
the sum of 100% of the RSF of our consolidated properties and our share of the
RSF of properties held in unconsolidated real estate joint ventures. As of
December 31, 2021, approximately 91% of our leases (on an RSF basis) were triple
net leases, which require tenants to pay substantially all real estate taxes,
insurance, utilities, repairs and maintenance, common area expenses, and other
operating expenses (including increases thereto) in addition to base rent.
Annual rental revenue excludes these operating expenses recovered from our
tenants. Amounts recovered from our tenants related to these operating expenses,
along with base rent, are classified in income from rentals in our consolidated
statements of operations.

Capitalization rates

Capitalization rates are calculated based upon net operating income and net operating income (cash basis) annualized for the quarter preceding the date on which the property is sold, or near term prospective net operating income.

Cash interest



Cash interest is equal to interest expense calculated in accordance with GAAP
plus capitalized interest, less amortization of loan fees and debt premiums
(discounts). Refer to the definition of "Fixed-charge coverage ratio" in this
section under this Item 7 in this annual report on 10-K for a reconciliation of
interest expense, the most directly comparable financial measure calculated and
presented in accordance with GAAP, to cash interest.

Class A properties and AAA locations



Class A properties are properties clustered in AAA locations that provide
innovative tenants with highly dynamic and collaborative environments that
enhance their ability to successfully recruit and retain world-class talent and
inspire productivity, efficiency, creativity, and success. Class A properties
generally command higher annual rental rates than other classes of similar
properties.

AAA locations are in close proximity to concentrations of specialized skills,
knowledge, institutions, and related businesses. Such locations are generally
characterized by high barriers to entry for new landlords, high barriers to exit
for tenants, and a limited supply of available space.

Development, redevelopment, and pre-construction



A key component of our business model is our disciplined allocation of capital
to the development and redevelopment of new Class A properties, and property
enhancements identified during the underwriting of certain acquired properties,
located in collaborative life science, agtech, and technology campuses in AAA
innovation clusters. These projects are generally focused on providing
high-quality, generic, and reusable spaces that meet the real estate
requirements of, and are reusable by, a wide range of tenants. Upon completion,
each value-creation project is expected to generate a significant increase in
rental income, net operating income, and cash flows. Our development and
redevelopment projects are generally in locations that are highly desirable to
high-quality entities, which we believe results in higher occupancy levels,
longer lease terms, higher rental income, higher returns, and greater long-term
asset value.

Development projects generally consist of the ground-up development of generic
and reusable facilities. Redevelopment projects consist of the permanent change
in use of office, warehouse, and shell space into office/laboratory, agtech, or
tech office space. We generally will not commence new development projects for
aboveground construction of new Class A office/laboratory, agtech, and tech
office space without first securing significant pre-leasing for such space,
except when there is solid market demand for high-quality Class A properties.

Pre-construction activities include entitlements, permitting, design, site work,
and other activities preceding commencement of construction of aboveground
building improvements. The advancement of pre-construction efforts is focused on
reducing the time required to deliver projects to prospective tenants. These
critical activities add significant value for future ground-up development and
are required for the vertical construction of buildings. Ultimately, these
projects will provide high-quality facilities and are expected to generate
significant revenue and cash flows.

Development, redevelopment, and pre-construction spending also includes the
following costs: (i) certain tenant improvements and renovations that will be
reimbursed, (ii) amounts to bring certain acquired properties up to market
standard and/or other costs identified during the acquisition process (generally
within two years of acquisition), and (iii) permanent conversion of space for
highly flexible, move-in-ready office/laboratory space to foster the growth of
promising early- and growth-stage life science companies.

                                      142
--------------------------------------------------------------------------------

Revenue-enhancing and repositioning capital expenditures represent spending to reposition or significantly change the use of a property, including through improvement in the asset quality from Class B to Class A.



Non-revenue-enhancing capital expenditures represent costs required to maintain
the current revenues of a stabilized property, including the associated costs
for renewed and re-leased space.

Fixed-charge coverage ratio



Fixed-charge coverage ratio is a non-GAAP financial measure representing the
ratio of Adjusted EBITDA to fixed charges. We believe this ratio is useful to
investors as a supplemental measure of our ability to satisfy fixed financing
obligations and preferred stock dividends. Cash interest is equal to interest
expense calculated in accordance with GAAP plus capitalized interest, less
amortization of loan fees and debt premiums (discounts).

The following table reconciles interest expense, the most directly comparable
financial measure calculated and presented in accordance with GAAP, to cash
interest and fixed charges for the three months and years ended December 31,
2021 and 2020 (dollars in thousands):
                                                   Three Months Ended December 31,                 Year Ended December 31,
                                                      2021                   2020                 2021                  2020
Adjusted EBITDA                                $        407,811          $  332,902          $  1,517,838          $ 1,274,187

Interest expense                               $         34,862          $ 

37,538 $ 142,165 $ 171,609 Capitalized interest

                                     44,078              37,589               170,641              125,618
Amortization of loan fees                                (2,911)             (2,905)              (11,441)             (10,494)
Amortization of debt premiums                               502                 869                 2,041                3,555
Cash interest and fixed charges                $         76,531          $  

73,091 $ 303,406 $ 290,288



Fixed-charge coverage ratio:
- period annualized                                           5.3x                4.6x                  5.0x                 4.4x
- trailing 12 months                                          5.0x                4.4x                  5.0x                 4.4x



Gross assets

Gross assets is calculated as total assets plus accumulated depreciation (in
thousands):
                                     December 31,
                                2021              2020
Total assets               $ 30,219,373      $ 22,827,878

Accumulated depreciation 3,771,241 3,182,438 Gross assets

$ 33,990,614      $ 26,010,316

Initial stabilized yield (unlevered)



Initial stabilized yield is calculated as the estimated amounts of net operating
income at stabilization divided by our investment in the property. Our initial
stabilized yield excludes the benefit of leverage. Our cash rents related to our
value-creation projects are generally expected to increase over time due to
contractual annual rent escalations. Our estimates for initial stabilized
yields, initial stabilized yields (cash basis), and total costs at completion
represent our initial estimates at the commencement of the project. We expect to
update this information upon completion of the project, or sooner if there are
significant changes to the expected project yields or costs.
•Initial stabilized yield reflects rental income, including contractual rent
escalations and any rent concessions over the term(s) of the lease(s),
calculated on a straight-line basis.
•Initial stabilized yield (cash basis) reflects cash rents at the stabilization
date after initial rental concessions, if any, have elapsed and our total cash
investment in the property.

                                      143
--------------------------------------------------------------------------------

Investment-grade or publicly traded large cap tenants



Investment-grade or publicly traded large cap tenants represent tenants that are
investment-grade rated or publicly traded companies with an average daily market
capitalization greater than $10 billion for the twelve months ended December 31,
2021, as reported by Bloomberg Professional Services. Credit ratings from
Moody's Investors Service and S&P Global Ratings reflect credit ratings of the
tenant's parent entity, and there can be no assurance that a tenant's parent
entity will satisfy the tenant's lease obligation upon such tenant's default. We
monitor the credit quality and related material changes of our tenants. Material
changes that cause a tenant's market capitalization to decrease below $10
billion, which are not immediately reflected in the twelve-month average, may
result in their exclusion from this measure.

Investments in real estate - value-creation square footage currently in rental properties



The square footage presented in the table below includes RSF of buildings in
operation as of December 31, 2021, primarily representing lease expirations at
recently acquired properties that also have inherent future development or
redevelopment opportunities, for which we have the intent to demolish or
redevelop the existing property upon expiration of the existing in-place leases
and commencement of future construction:
                                                                                                        RSF of lease expirations going into
                                                                                                           development and redevelopment
Property/Submarket                                      Dev/Redev               2022                     2023                     Thereafter                   Total
Near-term projects:
40 Sylvan Road/Route 128                                  Redev                      -                  312,845                             -                 312,845
651 Gateway Boulevard/South San Francisco                 Redev                197,787                        -                       102,223     (1)   

300,010


3825 Fabian Way/Greater Stanford                          Redev                250,000                        -                             -           

250,000


3450 Hillview Avenue/Greater Stanford                     Redev                 42,340                        -                             -          

42,340

11255 and 11355 North Torrey Pines Road/Torrey
Pines                                                      Dev                 139,135                        -                             -           

139,135

10931 and 10933 North Torrey Pines Road/Torrey
Pines                                                      Dev                  92,450                        -                             -                  92,450
3301 Monte Villa Parkway                                  Redev                 51,255                        -                             -                  51,255
41 Moore Drive/Research Triangle                          Redev                 62,490                        -                             -                  62,490
                                                                               835,457                  312,845                       102,223               1,250,525
Intermediate-term projects:
3460 Hillview Avenue/Greater Stanford                     Redev                      -                        -                        34,611           

34,611


9444 Waples Street/Sorrento Mesa                           Dev                  30,855                        -                        57,525     (1)          88,380
                                                                                30,855                        -                        92,136                 122,991
Future projects:
550 Arsenal Street/Cambridge/Inner Suburbs                 Dev                       -                        -                       260,867           

260,867

380 and 420 E Street/Seaport Innovation
District                                                   Dev                       -                        -                       195,506                 195,506
Other/Greater Boston                                      Redev                      -                        -                       167,549     (1)         167,549
1122 El Camino Real/South San Francisco                    Dev                       -                        -                       223,232           

223,232


3875 Fabian Way/Greater Stanford                          Redev                      -                        -                       228,000           

228,000


960 Industrial Road/Greater Stanford                       Dev                       -                        -                       110,000           

110,000


2475 Hanover Street/Greater Stanford                      Redev                      -                        -                        83,980           

83,980


219 East 42nd Street/New York City                         Dev                       -                        -                       349,947           

349,947


10975 and 10995 Torreyana Road/Torrey Pines                Dev                       -                        -                        84,829           

84,829


4161 Campus Point Court/University Town Center             Dev                       -                  159,884                             -           

159,884


10260 Campus Point Drive/University Town Center            Dev                       -                  109,164                             -           

109,164


Sequence District by Alexandria/Sorrento Mesa           Dev/Redev                    -                        -                       689,938           

689,938


4025, 4031, and 4045 Sorrento Valley                       Dev                  42,594                        -                             -          

42,594

Boulevard/Sorrento Valley
601 Dexter Avenue North/Lake Union                         Dev                       -                        -                        18,680                  18,680
830 4th Avenue South/SoDo                                  Dev                       -                        -                        42,380                  42,380
Other/Seattle                                              Dev                       -                   84,782                        17,655     (1)         102,437
Other                                                      TBD                  70,700                        -                        72,405     (1)         143,105
                                                                               113,294                  353,830                     2,544,968               3,012,092
                                                                               979,606                  666,675                     2,739,327               4,385,608

(1)Includes vacant square footage as of December 31, 2021.


                                      144
--------------------------------------------------------------------------------

Joint venture financial information



We present components of balance sheet and operating results information related
to our real estate joint ventures, which are not presented, or intended to be
presented, in accordance with GAAP. We present the proportionate share of
certain financial line items as follows: (i) for each real estate joint venture
that we consolidate in our financial statements, which are controlled by us
through contractual rights or majority voting rights, but of which we own less
than 100%, we apply the noncontrolling interest economic ownership percentage to
each financial item to arrive at the amount of such cumulative noncontrolling
interest share of each component presented; and (ii) for each real estate joint
venture that we do not control and do not consolidate, and are instead
controlled jointly or by our joint venture partners through contractual rights
or majority voting rights, we apply our economic ownership percentage to each
financial item to arrive at our proportionate share of each component presented.

The components of balance sheet and operating results information related to our
real estate joint ventures do not represent our legal claim to those items. For
each entity that we do not wholly own, the joint venture agreement generally
determines what equity holders can receive upon capital events, such as sales or
refinancing, or in the event of a liquidation. Equity holders are normally
entitled to their respective legal ownership of any residual cash from a joint
venture only after all liabilities, priority distributions, and claims have been
repaid or satisfied.

We believe this information can help investors estimate the balance sheet and
operating results information related to our partially owned entities.
Presenting this information provides a perspective not immediately available
from consolidated financial statements and one that can supplement an
understanding of the joint venture assets, liabilities, revenues, and expenses
included in our consolidated results.

The components of balance sheet and operating results information related to our
real estate joint ventures are limited as an analytical tool as the overall
economic ownership interest does not represent our legal claim to each of our
joint ventures' assets, liabilities, or results of operations. In addition,
joint venture financial information may include financial information related to
the unconsolidated real estate joint ventures that we do not control. We believe
that in order to facilitate for investors a clear understanding of our operating
results and our total assets and liabilities, joint venture financial
information should be examined in conjunction with our consolidated statements
of operations and balance sheets. Joint venture financial information should not
be considered an alternative to our consolidated financial statements, which are
presented and prepared in accordance with GAAP.

Mega campus



Mega campuses are cluster campuses that consist of approximately 1 million or
more RSF, including operating, active development/redevelopment, and land RSF
less operating RSF expected to be demolished. The following table reconciles our
operating RSF as of December 31, 2021:

                                                                      Operating RSF
Mega campus                                                            24,599,149
Non-mega campus                                                        14,236,643
Total                                                                  38,835,792

Mega campus RSF as a percentage of total operating property RSF             

63 %

Net cash provided by operating activities after dividends



Net cash provided by operating activities after dividends includes the deduction
for distributions to noncontrolling interests. For purposes of this calculation,
changes in operating assets and liabilities are excluded as they represent
timing differences.

Net debt and preferred stock to Adjusted EBITDA



Net debt and preferred stock to Adjusted EBITDA is a non-GAAP financial measure
that we believe is useful to investors as a supplemental measure of evaluating
our balance sheet leverage. Net debt and preferred stock is equal to the sum of
total consolidated debt less cash, cash equivalents, and restricted cash, plus
preferred stock outstanding as of the end of the period. Refer to the definition
of "Adjusted EBITDA and Adjusted EBITDA margin" under Item 7 in this annual
report on Form 10-K for further information on the calculation of Adjusted
EBITDA.

                                      145
--------------------------------------------------------------------------------

The following table reconciles debt to net debt and preferred stock and computes
the ratio to Adjusted EBITDA as of December 31, 2021 and 2020 (dollars in
thousands):
                                                                   December 31,
                                                              2021              2020
Secured notes payable                                    $   205,198       $   230,925
Unsecured senior notes payable                             8,316,678        

7,232,370

Unsecured senior line of credit and commercial paper 269,990

99,991


Unamortized deferred financing costs                          65,476            56,312
Cash and cash equivalents                                   (361,348)         (568,532)
Restricted cash                                              (53,879)          (29,173)
Preferred stock                                                    -                 -
Net debt and preferred stock                             $ 8,442,115       $ 7,021,893

Adjusted EBITDA:
- quarter annualized                                     $ 1,631,244       $ 1,331,608
- trailing 12 months                                     $ 1,517,838       $ 1,274,187

Net debt and preferred stock to Adjusted EBITDA:
- quarter annualized                                             5.2  x            5.3  x
- trailing 12 months                                             5.6  x            5.5  x


Net operating income, net operating income (cash basis), and operating margin



The following table reconciles net income to net operating income, and to net
operating income (cash basis) for the years ended December 31, 2021, 2020, and
2019 (dollars in thousands):
                                                                       Year Ended December 31,
                                                            2021                 2020                 2019
Net income                                             $   654,282          $   827,171          $   404,047

Equity in earnings of unconsolidated real estate
joint ventures                                             (12,255)              (8,148)             (10,136)
General and administrative expenses                        151,461              133,341              108,823
Interest expense                                           142,165              171,609              173,675
Depreciation and amortization                              821,061              698,104              544,612
Impairment of real estate                                   52,675               48,078               12,334
Loss on early extinguishment of debt                        67,253               60,668               47,570
Gain on sales of real estate                              (126,570)            (154,089)                (474)
Investment income                                         (259,477)            (421,321)            (194,647)
Net operating income                                     1,490,595            1,355,413            1,085,804
Straight-line rent revenue                                (115,145)             (96,676)            (104,235)
Amortization of acquired below-market leases               (54,780)             (57,244)             (29,813)
Net operating income (cash basis)                      $ 1,320,670

$ 1,201,493 $ 951,756



Net operating income (from above)                      $ 1,490,595          $ 1,355,413          $ 1,085,804
Total revenues                                         $ 2,114,150          $ 1,885,637          $ 1,531,296
Operating margin                                                  71%                  72%                  71%




                                      146

--------------------------------------------------------------------------------

Net operating income is a non-GAAP financial measure calculated as net income,
the most directly comparable financial measure calculated and presented in
accordance with GAAP, excluding equity in the earnings of our unconsolidated
real estate joint ventures, general and administrative expenses, interest
expense, depreciation and amortization, impairments of real estate, gains or
losses on early extinguishment of debt, gains or losses on sales of real estate,
and investment income or loss. We believe net operating income provides useful
information to investors regarding our financial condition and results of
operations because it primarily reflects those income and expense items that are
incurred at the property level. Therefore, we believe net operating income is a
useful measure for investors to evaluate the operating performance of our
consolidated real estate assets. Net operating income on a cash basis is net
operating income adjusted to exclude the effect of straight-line rent and
amortization of acquired above- and below-market lease revenue adjustments
required by GAAP. We believe that net operating income on a cash basis is
helpful to investors as an additional measure of operating performance because
it eliminates straight-line rent revenue and the amortization of acquired above-
and below-market leases.

Furthermore, we believe net operating income is useful to investors as a
performance measure of our consolidated properties because, when compared across
periods, net operating income reflects trends in occupancy rates, rental rates,
and operating costs, which provide a perspective not immediately apparent from
net income or loss. Net operating income can be used to measure the initial
stabilized yields of our properties by calculating net operating income
generated by a property divided by our investment in the property. Net operating
income excludes certain components from net income in order to provide results
that are more closely related to the results of operations of our properties.
For example, interest expense is not necessarily linked to the operating
performance of a real estate asset and is often incurred at the corporate level
rather than at the property level. In addition, depreciation and amortization,
because of historical cost accounting and useful life estimates, may distort
comparability of operating performance at the property level. Impairments of
real estate have been excluded in deriving net operating income because we do
not consider impairments of real estate to be property-level operating expenses.
Impairments of real estate relate to changes in the values of our assets and do
not reflect the current operating performance with respect to related revenues
or expenses. Our impairments of real estate represent the write-down in the
value of the assets to the estimated fair value less cost to sell. These
impairments result from investing decisions or a deterioration in market
conditions. We also exclude realized and unrealized investment gain or loss,
which results from investment decisions that occur at the corporate level
related to non-real estate investments in publicly traded companies and certain
privately held entities. Therefore, we do not consider these activities to be an
indication of operating performance of our real estate assets at the property
level. Our calculation of net operating income also excludes charges incurred
from changes in certain financing decisions, such as losses on early
extinguishment of debt, as these charges often relate to corporate strategy.
Property operating expenses included in determining net operating income
primarily consist of costs that are related to our operating properties, such as
utilities, repairs, and maintenance; rental expense related to ground leases;
contracted services, such as janitorial, engineering, and landscaping; property
taxes and insurance; and property-level salaries. General and administrative
expenses consist primarily of accounting and corporate compensation, corporate
insurance, professional fees, office rent, and office supplies that are incurred
as part of corporate office management. We calculate operating margin as net
operating income divided by total revenues.

We believe that in order to facilitate for investors a clear understanding of
our operating results, net operating income should be examined in conjunction
with net income or loss as presented in our consolidated statements of
operations. Net operating income should not be considered as an alternative to
net income or loss as an indication of our performance, nor as an alternative to
cash flows as a measure of our liquidity or our ability to make
distributions.

Operating statistics



We present certain operating statistics related to our properties, including
number of properties, RSF, occupancy percentage, leasing activity, and
contractual lease expirations as of the end of the period. We believe these
measures are useful to investors because they facilitate an understanding of
certain trends for our properties. We compute the number of properties, RSF,
occupancy percentage, leasing activity, and contractual lease expirations at
100% for all properties in which we have an investment, including properties
owned by our consolidated and unconsolidated real estate joint ventures. For
operating metrics based on annual rental revenue, refer to the definition of
"Annual rental revenue" in this "Non-GAAP measures and definitions" section.

                                      147
--------------------------------------------------------------------------------

Same property comparisons



As a result of changes within our total property portfolio during the
comparative periods presented, including changes from assets acquired or sold,
properties placed into development or redevelopment, and development or
redevelopment properties recently placed into service, the consolidated total
income from rentals, as well as rental operating expenses in our operating
results, can show significant changes from period to period. In order to
supplement an evaluation of our results of operations over a given quarterly or
annual period, we analyze the operating performance for all consolidated
properties that were fully operating for the entirety of the comparative periods
presented, referred to as same properties. We separately present quarterly and
year-to-date same property results to align with the interim financial
information required by the SEC in our management's discussion and analysis of
our financial condition and results of operations. These same properties are
analyzed separately from properties acquired subsequent to the first day in the
earliest comparable quarterly or year-to-date period presented, properties that
underwent development or redevelopment at any time during the comparative
periods, unconsolidated real estate joint ventures, properties classified as
held for sale, and corporate entities (legal entities performing general and
administrative functions), which are excluded from same property results.
Additionally, termination fees, if any, are excluded from the results of same
properties. Refer to the "Same properties" subsection in the "Results of
operations" section within this Item 7 in this annual report on Form 10-K for
additional information.

Stabilized occupancy date

The stabilized occupancy date represents the estimated date on which the project is expected to reach occupancy of 95% or greater.

Tenant recoveries



Tenant recoveries represent revenues comprising reimbursement of real estate
taxes, insurance, utilities, repairs and maintenance, common area expenses, and
other operating expenses and earned in the period during which the applicable
expenses are incurred and the tenant's obligation to reimburse us arises.

We classify rental revenues and tenant recoveries generated through the leasing
of real estate assets within revenue in income from rentals in our consolidated
statements of operations. We provide investors with a separate presentation of
rental revenues and tenant recoveries in the "Comparison of results for the year
ended December 31, 2021 to the year ended December 31, 2020" subsection of the
"Results of operations" section within this Item 7 because we believe it
promotes investors' understanding of our operating results. We believe that the
presentation of tenant recoveries is useful to investors as a supplemental
measure of our ability to recover operating expenses under our triple net
leases, including recoveries of utilities, repairs and maintenance, insurance,
property taxes, common area expenses, and other operating expenses, and of our
ability to mitigate the effect to net income for any significant variability to
components of our operating expenses.

The following table reconciles income from rentals to tenant recoveries for the years ended December 31, 2021, 2020, and 2019 (in thousands):


                                                    Year Ended December 31,
                                            2021             2020             2019
             Income from rentals        $ 2,108,249      $ 1,878,208      $ 1,516,864
             Rental revenues             (1,618,592)      (1,471,840)     

(1,165,788)


             Tenant recoveries          $   489,657      $   406,368      $   351,076


Total market capitalization

Total market capitalization is equal to the outstanding shares of common stock
at the end of the period multiplied by the closing price on the last trading day
of the period (i.e., total equity capitalization), plus total debt outstanding
at period-end.

Unencumbered net operating income as a percentage of total net operating income



Unencumbered net operating income as a percentage of total net operating income
is a non-GAAP financial measure that we believe is useful to investors as a
performance measure of the results of operations of our unencumbered real estate
assets as it reflects those income and expense items that are incurred at the
unencumbered property level. Unencumbered net operating income is derived from
assets classified in continuing operations, which are not subject to any
mortgage, deed of trust, lien, or other security interest, as of the period for
which income is presented.

                                      148
--------------------------------------------------------------------------------

The following table summarizes unencumbered net operating income as a percentage
of total net operating income for the years ended December 31, 2021, 2020, and
2019 (dollars in thousands):
                                                               Year Ended 

December 31,


                                                  2021                  2020                  2019
Unencumbered net operating income            $  1,444,307          $  1,295,520          $  1,024,619
Encumbered net operating income                    46,288                59,893                61,185
Total net operating income                   $  1,490,595          $  1,355,413          $  1,085,804
Unencumbered net operating income as a
percentage of total net operating income                 97%                   96%                   94%



Weighted-average shares of common stock outstanding - diluted



From time to time, we enter into capital market transactions, including forward
equity sales agreements ("Forward Agreements"), to fund acquisitions, to fund
construction of our highly leased development and redevelopment projects, and
for general working capital purposes. We are required to consider the potential
dilutive effect of our forward equity sales agreements under the treasury stock
method while the forward equity sales agreements are outstanding. As of
December 31, 2021, we had no Forward Agreements outstanding. Refer to Note 15 -
"Stockholders' equity" to our consolidated financial statements under Item 15 in
this annual report on Form 10-K for additional information.

The weighted-average shares of common stock outstanding used in calculating EPS
- diluted, funds from operations per share - diluted, and funds from operations
per share - diluted, as adjusted, for the years ended December 31, 2021, 2020,
and 2019, are calculated as follows (in thousands):
                                                                            

Year Ended December 31,


                                                       2021                            2020                          2019
Weighted-average shares of common stock
outstanding:
Basic shares for EPS                                     146,921                         126,106                       112,204
Outstanding forward equity sales agreements                  539                             384                           320
Series D Convertible Preferred Stock                           -                               -                             -
Diluted shares for EPS                                   147,460                         126,490                       112,524

Basic shares for EPS                                     146,921                         126,106                       112,204
Outstanding forward equity sales agreements                  539                             384                           320
Series D Convertible Preferred Stock                           -                               -                           442
Diluted shares for FFO                                   147,460                         126,490                       112,966

Basic shares for EPS                                     146,921                         126,106                       112,204
Outstanding forward equity sales agreements                  539                             384                           320
Series D Convertible Preferred Stock                           -                               -                             -
Diluted shares for FFO, as adjusted                      147,460                         126,490                       112,524


                                      149

--------------------------------------------------------------------------------

© Edgar Online, source Glimpses